Stachybotrys chartarum: Cause of human disease or media darling?

Medical Mycology

Volumn 41, Issue 4, 2003, Pages 271-291

  David Miller, J ^a   Rand, Thomas G ^b   Jarvis, Bruce B ^c  

^a CARLETON UNIVERSITY   (Canada)

^b SAINT MARY S UNIVERSITY   (Canada)

^c Bldg 142   (United States)

Author keywords

Allergens; Disease; Public health; Stachybotrys chartarum; Toxins

Indexed keywords

CELLULOSE;

ASTHMA; BUILDING MATERIAL; COGNITIVE DEFECT; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE SEVERITY; EXPOSURE; FUNGAL CONTAMINATION; FUNGUS GROWTH; HUMAN; LUNG HEMOSIDEROSIS; LUNG INJURY; MATERIALS HANDLING; MOULD; MYCOSIS; NONHUMAN; ORGANISM COLONY; PUBLIC HEALTH; REVIEW; STACHYBOTRYS CHARTARUM; UPPER RESPIRATORY TRACT INFECTION; WETTABILITY;

ALLERGENS; ANIMALS; HUMANS; HYPERSENSITIVITY; LUNG DISEASES, FUNGAL; MICE; MICE, INBRED BALB C; MYCOSES; MYCOTOXINS; PUBLIC HEALTH; STACHYBOTRYS;

ANIMALIA; FUNGI; STACHYBOTRYS CHARTARUM;

EID: 0041823866     PISSN: 13693786     EISSN: None     Source Type: Journal    
DOI: 10.1080/1369378031000137350     Document Type: Review

References (147)

1. Miller JD. Global significance of mycotoxins. In: Miraglia M, van Egmond M, Brera C, Gilbert J (eds). Mycotoxins and Phycotoxins - Developments in Chemistry, Toxicology and Food Safety. Fort Collins, CO: Alaken Press, 1998: 1-9.
2. Miller JD. Mycotoxins. In: Francis FJ (ed.). Encylopedia of Food Science and Technology. New York, NY: John Wiley, 1999: 1698-1706.
3. Health Canada. Indoor Molds. Ottawa, ON: Health Canada, 2003.
4. NAS. Clearing the Air. Washington, DC: National Academy Press, 2000.
5. Jong SC, Davis EE. Contribution to the knowledge of Stachybotrys and Memnoniella in culture. Mycotaxon 1976; 3: 409-485.
6. Koster B, Scott J, Wong B, Malloch D, Straus N. A geographically diverse set of isolates indicates two phylogenetic lineages within Stachybotrys chartarum. Can J Bot 2003 (in press).
7. Andersen B, Nissen N. Evaluation of media for detection of Stachybotrys and Chaetomium species associated with water-damaged buildings. Int Biodeter Biodeg 2000; 46: 111-116.
8. Tsai SM, Yang CS, Heinsohn P. Comparative studies of fungal media for the recovery of Stachybotrys chartarum from environmental samples. In: Johanning E (ed.). Bioaerosols, Fungi and Mycotoxins: Health Effects, Assessment, Prevention and Control. Albany, NY: Eastern New York Occupational and Environmental Health Center, 1999.
9. Bisby GR. Stachybotrys. Trans Br Mycol Soc 1943; 26: 133-143.
10. Hughes SJ. Revisiones Hyphomycetum aliquot cum appendice de nominibus rejeciendis. Can J Bot 1958; 36: 727-836.
11. Miller JD, Greenhalgh R, Wang YZ, Lu M. Mycotoxin chemotypes of three Fusarium species. Mycologia 1991; 83: 121-130.
12. Andersen B, Nielsen KF, Jarvis BB. Characterization of Stachybotrys from water-damaged buildings based on morphology, growth and metabolite production. Mycologia 2002; 94: 392-403.
13. Jarvis B, Sorenson WG, Hintikka E, et al. Study of toxin production by isolates of Stachybotrys chartarum and Memnoniella echinata isolated during a study of pulmonary hemosiderosis in infants. Appl Environ Microbiol 1998; 64: 3620-3625.
14. Cruse M, Telerant R, Gallagher T, Lee T, Taylor J. Cryptic species in Stachybotrys chartarum. Mycologia 2002; 94: 814-822.
15. Zuck RK. Isolates intermediate between Stachybotrys and Memnoniella. Mycologia 1946; 38: 69-76.
16. Smith G. Some new and interesting species of microfungi. Trans Br Mycol Soc 1962; 45: 387-394.
17. Kendrick WB, Carmichael JW. Hyphomycetes. In: Ainsworth GC, Sparrow FK, Sussman AS (eds). The Fungi, vol. IVa. New York: Academic Press, 1973: 323-509.
18. Barron G. The Genera of Hyphomycetes from Soil. Baltimore: Williams & Wilkins, 1968.
19. Carmichael JW, Kendrick WB, Conners IL, Sigler L. Genera of Hyphomycetes. Calgary: University of Alberta Press, 1980.
20. Li D-W, Yang CS, Haugland R, Vesper S. A new species of Memnoniella. Mycotaxon 2003; 85: 253-257.
21. Haugland RA, Vesper SJ, Harmon S. Phylogenetic relationships of Memnoniella and Stachybotrys species inferred from ribosomal DNA sequences and evaluation of morphological features for Memnoniella species identification. Mycologia 2001; 93: 54-65.
22. Peltola J, Niessen L, Nielsen KF, et al. Toxigenic diversity of two different RAPD groups of Stachybotrys chartarum isolates analyzed by potential for trichothecene production and for boar sperm cell motility inhibition. Can J Microbiol 2002; 48: 1017-1029.
23. Jarvis BB, Zhou Y, Wang S, et al. Toxigenic molds in water-damaged buildings: Dechlorogriseofulvins from Memnoniella echinata. J Nat Prod 1996; 59: 553-54.
24. Ellis MB. Dematiaceous Hyphomycetes. Wallingford, UK: CAB International, 1971.
25. Haugland RA, Vesper SJ, Wymer LJ. Quantitative measurement of Stachybotrys chartarum conidia using real time detection of PCR products with the TaqManTM fluorogenic probe system. Mol Cel Probes 1999; 13: 329-340.
26. Roe JD, Haugland RA, Vesper SJ, Wymer LJ. Quantification of Stachybotrys chartarum conidia in indoor dust using real time, fluorescent probe-based detection of PCR products. J Exp Analyt Environ Epidemiol 2001; 11: 12-20.
27. Miller JD. Mycological investigations of indoor environments. In: Flannigan B, Samson RA, Miller JD (eds). Microorganisms in Home and Indoor Work Environments: Diversity, Health Impacts, Investigation and Control. London: Taylor & Francis, 2001: 231-246.
28. Vesper S, Dearborn DG, Yike I, et al. Evaluation of Stachybotrys chartarum in the house of an infant with pulmonary hemorrhage: Quantitative assessment before, during and after remediation. J Urb Health: Bull NY Acad Med 2000; 77: 68-85.
29. Weiss A, Chidekel AS. Acute pulmonary hemorrhage in a Delaware infant after exposure to Stachybotrys atra. Delaware Med J 2002; 74: 363-368.
30. Yike I, Miller MJ, Tomashefski J, Walenga R, Dearborn D. Infant rat model of Stachybotrys chartarum induced mycotoxicosis. Mycopathologia 2002; 154: 139-152.
31. Denziel T, Jarvis B, Onions AHS, et al. A catalogue of potentially biodeteriogenic fungi in the culture collection of CBS, CINI and QM. Int Biodeter Bull 1974; 10: 3-23.
32. Ayerst G. The effects of moisture and temperature on growth and spore germination in some fungi. J Stored Prod Res 1969; 5: 127-141.
33. Grant C, Hunter CA, Flannigan B, Bravery AF. Water activity requirements of moulds isolated from domestic dwellings. Int Biodeter 1989; 25: 258-284.
34. Flannigan B, Miller JD. Microbial growth in indoor environments. In: Flannigan B, Samson RA, Miller JD (eds). Micro-organisms in Home and Indoor Work Environments: Diversity, Health Impacts, Investigation and Control.London: Taylor & Francis, 2001: 35-67.
35. Siu RGH. Microbial Decomposition of Cellulose. New York: Rinhold, 1951.
36. Sorenson WG, Jarvis BB, Zhou Y, et al. Toxine im Zusammenhang mit Stachybotrys und Memnoniella in Häusern mit Wasserschäden. In: Gareis M, Scheuer R (eds). Mykotoxin Workshop. Kulmbach, Germany: Institut für Mikrobiologie und Toxicologie der Bundesanstalt für Fleischforschung, 1996: 207-214.
37. Madelin TM, Johnson HE. Fungal and actinomycete spore aerosols measured at different humidities with an aerodynamic particle sizer. J Appl Bacteriol 1992; 72: 400-409.
38. Phalen RF, Oldham MJ. Methods for modeling particle deposition as a function of age. Resp Physiol 2001; 128: 119-130.
39. Gorny RL, Reponen T, Willeke K, et al. Fungal fragments as indoor air biocontaminants. Appl Environ Microbiol 2002; 68: 3522-3531.
40. Li D-W, Kendrick B. A year-round comparison of fungal spores in indoor and outdoor air. Mycologia 1995; 87: 190-195.
41. Robertson LD. Monitoring viable fungal and bacterial bioaerosol concentrations to identify acceptable levels for common indoor environments. Indoor Built Environ 1997; 6: 295-300.
42. Barnes C, Buckley S, Pacheco F, Portnoy J. IgE-reactive proteins from Stachybotrys chartarum. Ann Aller Asth Immunol 2002; 89: 29-33.
43. Halsey JF, Jensen JT, Miller JD. Immunological responses to Stachybotrys chartarum. Aller Clin Immunol 2000; 107; S317.
44. Raunio P, Karkkainen M, Virtanen T, Rautiainen J, Pasanen A-L. Preliminary description of antigenic components characteristic of Stachybotrys chartarum. Environ Res Sect 2001; A85: 256-255.
45. Kaise H, Shinohara M, Miyazaki W, et al. Structure of K-76, a complement inhibitor produced by Stachybotrys complementi nov.sp. K-76. J Chem Soc Chem Commun 1979; 726-727.
46. Roggo BE, Petersen F, Sills M, et al. Novel spirodihydrobenzo-furanlactams as antagonists of endothelin and as inhibitors of HIV-1 protease produced by Stachybotrys sp. I. Fermentation, isolation and biological activity. J Antibiot 1995; 49: 13-19.
47. Kaneto R, Dobashi K, Kojima I, et al. Mer-NF5003B, E and F, novel sesquiterpeneoids as avian myeloblastosis virus protease inhibitors produced by Stachybotrys sp. J Antibiot 1994; 47: 727-730.
48. Sakai K, Watanabe K, Masua K, et al. Isolation, characterization and biological activities of novel triprenyl phenols as pancreatic cholesterol esterase inhibitors produced by Stachybotrys sp. F-1839. J Antibiot 1995; 48: 447-456.
49. Stefanelli S, Sponga F, Ferrari P, et al. Inhibitors of myo-inositol monophosphatase, ATCC 20928 factors A and C isolation, physicochemical characterization and biological properties. J Antibiot 1996; 49: 611-616.
50. Minagawa K, Kouzuki S, Tani H, et al. Novel stachyflin derivatives from Stachybotrys sp. RF-7260. J Antibiot 2002; 55: 239-248.
51. Hinkley SF, Jiang J, Mazzola EP, Jarvis BB. Atranones: Novel diterpenoids from the toxigenic mold Stachybotrys atra. Tetrahedron Lett 1999; 40: 2725-2728.
52. Nikulin M, Reijula K, Jarvis B, Veijalainen P, Hintikka E-L. Effects of intranasal exposure to Stachybotrys atra. Fund Appl Toxicol 1997; 35: 182-188.
53. Sorenson WG, Frazer DG, Jarvis B, Simpson J, Robinson VA. Trichothecene mycotoxins in aerosolized conidia of Stachybotrys atra. Appl Environ Microbiol 1987; 53: 1370-1375.
54. Jarvis BB, Hinkley FF, Nielsen KF. Stachybotrys: An unusual mold associated with water-damaged buildings. Mycotoxin Res 2000; 16A: 105-108.
55. Jarvis BB, Lee Y-W, Yatawara SN, Cömezoglu CS. Trichothecenes produced by Stachybotrys atra from Eastern Europe. Appl Environ Microbiol 1986; 51: 915-918.
56. Hinkley SF, Mazzola EP, Fettinger JC, Lam Y-F, Jarvis BB. Atranones A-G: A unique series of metabolites from the toxigenic mold Stachybotrys chartarum. Phytochemistry 2000; 55: 663-673.
57. Rodríguez AD, González E, Ramírez C. The structural chemistry, reactivity, and total synthesis of dolabellane diterpenes. Tetrahedron 1998; 54: 11683-11729.
58. Iwashima M, Matsumoto Y, Takenaka Y, Iguchi K, Yamori T. New marine diterpenoids from the Okinawan soft coral Clavularia koellikeri. J Nat Prod 2002; 65: 1441-1446.
59. Nielsen KF, Huttunen K, Hyvaerinen A, et al. Metabolite profiles of Stachybotrys isolates from water-damaged buildings and their induction of inflammatory mediators and cytotoxicity in macrophages. Mycopathologia 2002; 154: 201-205.
60. Fogelmark B, Rylander R. (1,3)-β-D-glucan in some indoor air fungi. Indoor Built Environ 1997; 6: 291-294.
61. Rylander R, Lin R-H. (1,3)-β-D-glucan - Relationship to indoor air-related symptoms, allergy and asthma. Toxicology 2000; 152: 47-52.
62. Thorn J, Beijer L, Rylander R. Effects after inhalation of (1,3)-beta-D-glucan in healthy humans. Mediat Inflamm 2001; 10: 173-178.
63. Rylander R. Experimental exposures to 1,3 beta-D-glucan. ASHRAE Trans 1993: 338-340.
64. Vesper SJ, Dearborn DG, Elidemir O, Haugland RA. Quantification of siderophore and hymolsin from Stachybotrys chartarum strains, including a strain isolated from the lung of a child with pulmonary hemorrhage and hemosiderosis. Appl Environ Microbiol 2000; a66: 2678-2681.
65. Vesper SJ, Magnuson ML, Dearborn DG, Yike I, Haugland RA. Initial characterization of the hemolysin stachylysin from Stachybotrys chartarum. Infect Immun 2001; 69: 912-916.
66. Kordula T, Banbula A, Macomson J, Travis J. Isolation and properties of stachyrase A, chymotrypsin-like serine proteinase from Stachybotrys chartarum. Infect Immun 2002; 70: 419-421.
67. Kazutoshi S, Eisaku T, Miyauchi M, et al. FR901459, a novel immunosuppressant isolated from Stachybotrys chartarum no. 19392. J Antibiot 1993; 46: 1788-1798.
68. Croft WA, Jarvis BB, Yatawara CS. Airborne outbreak of trichothecene toxicosis. Atmos Environ 1986; 20: 549-552.
69. Nielsen KF. Mould growth on building materials. PhD Thesis, Technical Univesity of Denmark, Lyngby, 2002.
70. Nielsen KF, Thrane U, Larsen TO, Nielsen PA, Gravesen S. Production of mycotoxins on artificially inoculated building materials. Int Biodeter Biodeg 1998; 42: 9-16.
71. Hinkley SF, Jarvis BB. Method for Stachybotrys toxins. In: Truckness MW, Pohland AE (eds). Methods in Molecular Biology: Mycotoxin Protocols, vol. 157. Totowa, N.J.: Humana Press, 2000: 173-194.
72. Rao CY, Burge HA, Brain JD. The time course of responses to intratracheally instilled toxic Stachybotrys chartarum spores in rats. Mycopathologia 2000; b149: 27-34.
73. Drobotko VG. Stachybotryotoxicosis: A new disease of horses and humans. Am Rev Sov Med 1945; 2: 238-242.
74. Szathmary CI. Toxicosis and natural occurrence in Hungary. In: Ueno Y (ed.). Trichothecenes: Chemical Biological and Toxicological Aspects. New York: Elsevier, 1983: 229-250.
75. Eppley RM, Bailey WJ. 12,13-Epoxy-delta 9-trichothecenes as the probable mycotoxins responsible for stachybotryotoxicosis. Science 1973; 181: 758-60.
76. Le Bars J, Gerard JP, Michel C. Demonstration of stachybotryotoxicosis in France: A case of acute intoxication in deer. Ann Nutr Alimen 1977; 31: 509-517.
77. Tantaoui-Elaraki A, Mekouar SL, El-Hamidi M, Senhaji M. Toxigenic strains of Stachybotrys atra associated with poisonous straw in Morocco. Vet Hum Toxicol 1994; 36: 93-96.
78. Kriek NPJ, Marasas WFO. Trichothecene research in South Africa. In: Ueno Y (ed.). Trichothecenes: Chemical Biological and Toxicological Aspects. New York: Elsevier, 1983: 273-284.
79. Pepeljnjak S. Trichothecene problems in Yugoslavia. In: Ueno Y (ed.). Trichothecenes: Chemical Biological and Toxicological Aspects. New York: Elsevier, 1983: 265-272.
80. Creasia DA, Lambert RJ. Acute respiratory tract toxicity of the trichothecene mycotoxin T-2 toxin. In: Beasley VR (ed.). Trichothecene Mycotoxin Mycotoxins: Pathophysiologic Effects, vol. 1. Boca Raton, FL: CRC Press, 1989: 162-170.
81. Creasia DA, Thurman JD, Wannemacher RW, Bunner DL. Acute inhalation toxicity of T-2 mycotoxin in the rat and guinea pig. Fund Appl Toxicol 1990; 14: 54-59.
82. Cote LM, Beasley VR, Bratich PM, Swanson SP, Buck WB. Excretion of Deoxynivalenol and its metabolite in milk, urine and feces of lactating dairy cows. J Anim Sci 1968; 69: 2416-2423.
83. Prelusky DB, Rotter BA, Rotter RG. Toxicology of mycotoxins. In: Miller JD, Trenholm HL (eds). Mycotoxins in Grain: Compounds Other Than Aflatoxin. St Paul, MN: Eagan Press, 1994: 359-404.
84. Schneider DJ, Marasas WFO, Kuys JCD, Kriek NPJ, Van Schalkwyk GC. A field outbreak of suspected stachbotryotoxicosis in sheep. J SA Vet Assoc 1979; 50: 73.
85. Beasley VR. Trichothecene, Mycotoxin Mycotoxins: Pathophysiologic Effects, vol. 1 and 2. Boca Raton, FL: CRC Press, 1989.
86. Hintikka EL. Human stachybotrytoxicosis. In: Wyllie TD, Morehouse LG (eds). Mycotoxigenic Fungi, Mycotoxins, Mycotoxicoses: An Encyclopedic Handbook, vol. 3. New York: Marcel Dekker, 1978: 87-89.
87. Andrassy K, Horvath I, Lakos T, Toke Z. Mass incidence of mycotoxicoses in Hajdu-Bihar county. Mykosen 1980; 23: 130-133.
88. Le Bars J, Le Bars P. Etude du nuage de spores de Stachybotrys atra contaminant des pailles; Risques d'inhalation. Bull Soc Fr Mycol Méd 1985; 14: 321-324.
89. Recco P, Servantie J, De Graeve P, et al. A propos d'une stachybotrytoxicose d'allure endemique dans un club hippique de la région Toulousaine: Approche épidémiologique, clinique et diagnostique. Bull Soc Fr Mycol Med 1986; 15: 233-236.
90. Dill I, Trautmann C, Szewzyk R. Mass development of Stachybotrys chartarum on decomposable plant-pots made of recycling paper. Mycoses 1997; 40: 110-114.
91. Sorenson WG, Lewis DM. Organic dust toxic syndrome. In: Howard D, Miller JD (eds). The Mycota, vol. VII. Berlin: Springer-Verlag, 1996: 159-172.
92. NIOSH. Preventing organic dust toxic syndrome. DHHS publication 94-102. Cincinnati, OH: NIOSH, 1994.
93. Rylander R. The clinical panorama. In: Rylander R, Jacobs RR (eds). Organic Dusts. Boca Raton, FL: Lewis Publishers, 1994: 117-126.
94. Ueno Y. Trichothecenes: Chemical, Biological and Toxicological Aspects. New York: Elsevier, 1983.
95. Snijders CHA, Samson RA, Hoekstra ES, et al. Analysis of Fusarium causing dermal toxicosis in marram grass planters. Mycopathologia 1997; 135: 119-128.
96. Kozak PP Jr, Gallup J, Cummins LH, Gillman SA. Currently available methods for home mold surveys. II. Examples of problem homes surveyed. Ann Aller 1980; 45(3): 167-176.
97. ACGIH. Assessment and control of bioaerosols in the indoor environment. American Conference of Government Industrial Hygienists, Cincinnati, OH, 1999.
98. Dales RE, Miller JD. Building-related illness: Epidemiological and case-related evidence. In: Flannigan B, Samson RA, Miller JD (eds). Microorganisms in Home and Indoor Work Environments: Diversity, Health Impacts, Investigation and Control. London: Taylor & Francis, 2001: 217-230.
99. Johanning E, Morey PR, Jarvis BB. Clinical-epidemiological investigation of health effects caused by Stachybotrys atra building contamination. Proc IAQ 93 1993; 1: 225-230.
100. Johnanning E. Health problems related to fungal exposure- the example of toxigenic Stachybotrys chartarum (atra). In: Johnanning E, Yang CS (eds). Fungi and Bacteria in Indoor Air Environments. Latham, NY: Eastern New York Occupational Health Program, 12110, 1995: 169-182.
101. Johanning E, Biagini R, Hull D, et al. Health and immunology study following exposure to toxigenic fungi (Stachybotrys chartarum) in a water-damaged office environment. Int Arch Occup Environ Health 1996; 68: 207-218.
102. Morey P. Cleaning procedures for mold. Proc Health Build 1995; 95(3): 1-12.
103. Johanning E. Stachybotrys revisited. Clin Toxicol 1998; 36: 629-631.
104. Elidemir O, Colasurdo GN, Rossmann SN, Fan LL. Isolation of Stachybotrys from the lung of a child with pulmonary hemosiderosis. Pediatrics 1999; 104: 964-966.
105. Flappan SM, Portnoy J, Jones P, Barnes C. Infant pulmonary hemorrhage in a suburban home with water damage and mold (Stachybotrys atra). Environ Health Perspect 1999; 107: 927-930.
106. Montaña E, Etzel RA, Allans T, Horgan TE, Dearborn DG. Environmental risk factors associated with pediatric idiopathic pulmonary hemorrhage and hemosiderosis in a Cleveland community. Pediatrics 1997; 99: 1-8.
107. Etzel R, Montaña E, Sorenson W, Kullman G, Allan T, Olson D. Acute pulmonary hemorrhage in infants associated with exposure to Stachybotrys atra and other fungi. Arch Pediatr Adolesc Med 1998; 152: 757-762.
108. Dearborn DG, Yike I, Sorenson WG, Miller MJ, Etzel RA. Overview of investigations into pulmonary hemorrhage among infacts in Cleveland, Ohio. Environ Health Perspect 1999; 107(S): 495-499.
109. CDC. Update: Pulmonary hemorrhage/hemosiderosis among infants - Cleveland, Ohio, 1993-1996. Morbid Mortal Weekly Rep 2002; 49: 180-184.
110. Dearborn DG, Smith PG, Dahms BB, et al. Clinical profile of 30 infants with acute pulmonary hemorrhage in Cleveland. Pediatrics 2002; 110: 627-637.
111. CDC. Notice to readers: Availability of case definition for acute idiopathic pulmonary hemorrhage in infants. Morbid Mortal Weekly Rep 2001; 50: 494-495.
112. CDC. Pulmonary hemorrhage in infants. Morbid Mortal Weekly Rep 2002; 49: 180-184.
113. Viana ME, Coates NH, Gavett SH, et al. An extract of Stachybotrys chartarum causes allergic asthma-like responses in a BALB/c mouse model. Toxicol Sci 2000; 70: 98-109.
114. Land CJ, Lundstrom H, Werner S. Production of tremorgenic mycotoxins by isolates of Aspergillus fumigatus from sawmills in Sweden. Mycopathologia 1993; 124: 87-93.
115. Larsen TO, Frisvad JC. Production of volatiles and mycotoxins in conidia of common indoor Penicillium and Aspergillus species. In: Samson R, Flannigan B, Flannigan M, Graveson S (eds). Health Implications of Fungi in Indoor Environments. Amsterdam: Elsevier, 1994: 251-279.
116. Miller JD. Fungi as contaminants in indoor air. Atmos Environ 1992; 26: 2163-2172.
117. Wicklow DT, Shotwell OL. Intrafungal distribution of aflatoxins among conidia and sclerotia of Aspergillus flavus and Aspergillus parasiticus. Can J Microbiol 1983; 29: 1-5.
118. Yike I, Rand TG, Dearborn D. Proteases from the spores of toxigenic fungus Stachybotrys chartarum. Am J Resp Crit Care Med (American Thoracic Society Abstracts) 2002; 165(Suppl.): A537.
119. Feinberg B, MacLaughlin CS. Biochemical mechanism of action of trichothecene mycotoxins. In: Beasley VR (ed.). Trichothecene Mycotoxin Mycotoxins: Pathophysiologic Effects, vol. 1. Boca Raton, FL: CRC Press, 1989: 27-36.
120. Gyonggyossy-Issa MIC, Card RT, Fergusson DJ, Khachatourians GC. Prehaemolytic erythrocyte deformability changes caused by trichothecene T-2 toxin. Blood Cell 1986; 11: 393-403.
121. Khachatourians GC. Metabolic effects of the trichothecene T-2 toxin. Can J Physiol Pharmacol 1990; 68: 1004-1008.
122. Yang G-H, Jarvis BB, Chung Y-J, Pestka JJ. Apoptosis induction by the satratoxins and other trichothecene mycotoxins: Relationship to ERK, p38 MAPK, and SAPK/JNK activation. Toxicol Appl Pharmacol 2000; 164: 149-160.
123. Jarvis BB. Macrocyclic trichothecenes. In: Sharma RP, Salunkhe DK (eds). Mycotoxins and Phytoalexins in Human and Animal Health. Boca Raton, FL: CRC Press, 1991: 361-421.
124. Nikulin M, Reijula K, Jarvis BB, Hintikka E-L. Experimental lung mycotoxicosis in mice induced by Stachybotrys atra. Int J Exp Path 1996; 77: 213-218.
125. Rand TG, Mahoney M, White K, Oulton M. Microanatomical changes associated with alveolar type II cells in juvenile mice exposed to Stachybotrys chartarum and isolated toxin. Toxicol Sci 2002; 65: 239-245.
126. Mason CD, Rand TG, Oulton M, MacDonald JM, Scott JE. Effects of Stachybotrys chartarum (atra) conidia and isolated toxin on lung surfactant production and homeostasis. Nat Toxin 1998; 6: 27-33.
127. Mason C, Rand TG, Oulton M, MacDonald J. The effect of Stachybotrys chartarum spores and an isolated trichothecene, isosatratoxin F, on convertase activity in mice. Toxicol Appl Pharmacol 2001; 172: 21-28.
128. MaCrae KC, Rand TG, Shaw RA, et al. Analysis of pulmonary surfactant by Fourier-transform infrared spectroscopy following exposure to Stachybotrys chartarum (atra) spores. Chem Phys Lipid 2001; 110: 1-10.
129. Sumarah MW, Rand TG, Mason CD, et al. Effects of Stachybotrys chartarum spores and toxin on mouse lung surfactant phospholipid composition. In: Johanning E (ed.). Bioaerosols, Fungi and Mycotoxins: Health Effects, Assessment, Prevention and Control. Albany, NY: Eastern New York Occupational Environmental Health Center, 1999: 444-452.
130. Hastings C, Rand TG, Bergen HT et al. Stachybotrys chartarum alters surfactant-related phospholipids synthesis and CTP:cholinephosphate cytidyltransferase activity in isolated fetal rat type II cells. Toxicol Lett 2002 (in press).
131. Flemming J, Hudson B, Rand TG. Lung inflammatory responses in juvenile mice after intratracheal instillation of Stachybotrys chartarum spores. Exper Toxicol Pathol 2002 (in press).
132. Rao CY, Brain JD, Burge HA. Reduction of pulmonary toxicity of Stachybotrys chartarum spores by methanol extraction of mycotoxins. Appl Environ Microbiol 2000; a66: 2817-2821.
133. Rosenblum JH, Molina RM, Donaghey TC, Brain JD. Murine pulmonary responses to Stachybotrys chartarum have genetic determinants. Am J Resp Crit Care Med (American Thoracic Society Abstracts) 2002; 165(Suppl. 8): A537.
134. Peltola J, Andersson M, Mikkola R, Mussalo-Rauhamaa H, Salkinoja-Salonen M. Membrane toxic substances in water-damaged construction materials and fungal pure cultures. In: Johanning E (ed.). Bioaerosols, Fungi and Mycotoxins: Health Effects, Assessment, Prevention and Control. Albany, NY: Eastern New York Occupational and Environmental Health Center, 1999: 432-443.
135. Okumura H, Yoshino N, Sugiura Y, et al. Trichothecenes as potent inducers of apoptosis. In: Johanning E (ed.). Bioaerosols, Fungi and Mycotoxins: Health Effects, Assessment, Prevention and Control. Bioaerosols, Fungi and Mycotoxins: Health Effects, Assessment, Prevention and Control. 1999: 221-231.
136. Creasia DA, Thurman JD, Jones LJ, Neally ML, York CG, Wannamacher RW, Bunner DL. Acute inhalation toxicity of t-2 mycotoxin in mice. Fund Appl Toxicol 1987; 8: 230-235.
137. Marrs TC, Edginton JAG, Price PN, Upshall DG. Acute toxicity of T2 mycotoxin to the guinea pig by inhalation and subcutaneous routes. Br J Exp Path 1986; 67: 259-268.
138. Pang VF, Lambert RJ, Felsberg PJ, et al. Experimental T-2 toxicosis in swine following inhalation exposure: Clinical sign and effects on haematology, serum biochemistry, and immune response. Fund Appl Toxicol 1998; 11: 100-109.
139. Thurman JD, Creasia DA, Trotter RW. Mycotoxicosis caused by aerosolized T-2 toxin administered to female mice. Am J Vet Res 1988; 49: 1928-1931.
140. Gregory L, Rand TG, Dearborn D, Pestka J. Localization of satratoxin-G in Stachybotrys chartarum spores and spore-impacted mouse lung tissues using immunocytochemistry. Toxicol Pathol 2003 (in press).
141. Gregory L, Rand TG, Dearborn D, Yike I, Vesper S. Immunocyto-chemical localization of a hemolysin-like protein in Stachybotrys chartarum spores and spore-impacted mouse and rat lung tissues. Mycopathologia 2002; 56: 77-85.
142. Vesper SJ, Dearborn DG, Yike I, Sorenson WG, Haugland RA. Hemolysis, toxicity, and randomly amplified polymorphic DNA analysis of Stachybotrys chartarum strains. Appl Environ Microbiol 1999; 65: 3175-3181.
143. Guidelines on assessment and remediation of Stachybotrys atra in indoor environments. In: Johanning E, Yang CS, eds. Fungi and Bacteria in Indoor Air Environments. Latham: NY Eastern New York Occupational Health Program, 1995, 201-207.
144. Brook RD, Brook JR, Urch B, et al. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation 2002; 105: 1534-1537.
145. Kirkpatrick CJ, Bittinger F, Unger R, et al. The non-neuronal cholinergic system in the endothelium: Evidence and possible pathobiological significance. Jpn J Pharmacol 2001; 85: 24-28.
146. Johanning E, Landsbergis P, Gareis M, et al. Clinical experience and results of a Sentinel Health Investigation related to indoor fungal exposure. Env Health Perspect 1999; 107(S3):489-94.
147. Gordon WA, Johanning E, Haddad L. Cognitive impairment associated with exposure to toxigenic fungi. In: Johanning E (ed.). Bioaerosols, Fungi and Mycotoxins: Health Effects, Assessment, Prevention and Control. Latham, NY: Eastern New York Occupational Health Program, 1999: 94-98.