Accelerated intramyocellular triglyceride synthesis in skeletal muscle of high-fat-induced obese rats

International Journal of Obesity

Volumn 27, Issue 9, 2003, Pages 1014-1019

  Guo, Z K ^a   Jensen, M D ^a  

^a MAYO CLINIC   (United States)

Author keywords

Glycerol kinetics; Insulin resistance; Muscle lipid; TG glycerol cycle

Indexed keywords

FATTY ACID; GLUCOSE; GLYCEROL; INTRAMYOCELLULAR TRIGLYCERIDE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEMALE; FOOD DEPRIVATION; GASTROCNEMIUS MUSCLE; GLUCOSE BLOOD LEVEL; LIPID STORAGE; LIPOGENESIS; MUSCLE BIOPSY; NONHUMAN; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; SOLEUS MUSCLE;

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; FATTY ACIDS, NONESTERIFIED; GLYCEROL; MALE; MUSCLE, SKELETAL; OBESITY; RATS; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES;

ANIMALIA;

EID: 0041818422     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0802380     Document Type: Article

References (25)

1. Jacob S, Machann J, Rett K, Brechtel K, Volk A, Renn W, Maerker E, Matthaei S, Schick F, Claussen CD, Haring HU. Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offsprings of type 2 diabetic subjects. Diabetes 1999; 48: 1113-1119.
2. Koyama K, Chen G, Lee Y, Unger RH. Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity. Am J Physiol 1997; 273: E708-E713.
3. Pan DA, Lillioja S, Kriketos AD, Milner MR, Baur LA, Bogardus C, Jenkins AB, Storlien LH. Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 1997; 46: 983-988.
4. Sinha R, Dufour S, Petersen KF, LeBon V, Enoksson S, Ma YZ, Savoye M, Rothman DL, Shulman GI, Caprio S. Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes 2002; 51: 1022-1027.
5. Kraegen EW, Clark PW, Jenkins AB, Daley EA, Chisholm DJ, Storlien LH. Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats. Diabetes 1991; 40: 1397-1403.
6. Guo ZK, Burguera B, Jensen MD. Kinetics of intramuscular triglyceride fatty acids in exercising humans. J Appl Physiol 2000; 89: 2057-2064.
7. Guo ZK, Jensen MD. Intramuscular fatty acid metabolism evaluated with stable isotopic tracers. J Appl Physiol 1998; 84: 1674-1679.
8. Guo ZK, Jensen MD. Blood glycerol is an important precursor for intramuscular triacylglycerol synthesis. J Biol Chem 1999; 274: 23702-23706.
9. Dagenais GR, Tancredi RG, Zierler KL. Free fatty acid oxidation by forearm muscle at rest, and evidence for an intramuscular lipid pool in the human forearm. J Clin Invest 1976; 58: 421-431.
10. Dyck DJ, Peters SJ, Glatz J, Gorski J, Keizer H, Kiens B, Liu S, Richter EA, Spriet LL, van der Vusse GJ, Bonen A. Functional differences in lipid metabolism in resting skeletal muscle of various fiber types. Am J Physiol 1997; 272: E340-E351.
11. 14C oxidation and incorporation into neutral lipids by skeletal muscle in vitro. J Lipid Res 1961; 2: 376-382.
12. Folch J, Lees M, Sloane-Standley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497-509.
13. Christie WW. Rapid separation and quantification of lipid classes by high performance liquid chromatography and mass (light-scattering) detection. J Lipid Res 1985; 26: 507-512.
14. Humphrey SM, Fisher RM, Frayn KN. Micro-method for measurement of subnanomole amounts of triacylglycerol. Ann Clin Biochem 2000; 27: 597-598.
15. Zierler KL. Fatty acids as substrates for heart and skeletal muscle. Circ Res 1976; 38: 459-463.
16. Hurley BF, Nemeth PM, Martin WH III, Hagberg JM, Dalsky GP, Holloszy JO. Muscle triglyceride utilization during exercise: effect of training. J Appl Physiol 1986; 60: 562-567.
17. Rico-Sanz J, Moosavi M, Thomas EL, McCarthy J, Coutts GA, Saeed N, Bell JD. In vivo evaluation of the effects of continuous exercise on skeletal muscle triglycerides in trained humans. Lipids 2000; 35: 1313-1318.
18. Kiens B, Essen-Gustavsson B, Christensen NJ, Saltin B. Skeletal muscle substrate utilization during submaximal exercise in man: effect of endurance training. J Physiol (Lond) 1993; 469: 459-478.
19. Goodpaster BH, He J, Watkins S, Kelley DE. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 2001; 86: 5755-5761.
20. Kelley DE, Goodpaster B, Wing RR, Simoneau JA. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol 1999; 277: E1130-E1141.
21. Hegarty BD, Cooney GJ, Kraegen EW, Furler SM. Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats. Diabetes 2002; 51: 1477-1484.
22. Turcotte LP, Swenberger JR, Zavitz TM, Yee AJ. Increased fatty acid uptake and altered fatty acid metabolism in insulin-resistant muscle of obese Zucker rats. Diabetes 2001; 50: 1389-1396.
23. Vaughan L, Zurlo F, Ravussin E. Aging and energy expenditure. Am J Clin Nutr 1991; 53: 821-825.
24. Guo ZK. Triglyceride content in skeletal muscle: variability and the source. Anal Biochem 2001; 296: 1-8.
25. Guo ZK. Sampling the intramyocellular triglycerides from skeletal muscle. J Lipid Res 2001; 42: 1041-1048.