Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light

Biochemical Journal

Volumn 374, Issue 2, 2003, Pages 537-543

  Adams, Ryan A ^a   Liu, Xinran ^a,b   Williams, David S ^a   Newton, Alexandra C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Phosphorylation; Phototransduction; Protein kinase C (PKC); Rhodopsin; Rhodopsin kinase (RK); Signal transduction

Indexed keywords

ANTIBODIES; PROTEINS;

RHODOPSIN;

BIOCHEMISTRY;

PHORBOL ESTER; PROTEIN KINASE C; RHODOPSIN; RHODOPSIN KINASE; SERINE;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; LIGHT EXPOSURE; MOUSE; NONHUMAN; PHOSPHORYLATION; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; RETINA ROD;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; CATTLE; ENZYME ACTIVATION; EYE PROTEINS; HUMANS; LIGHT; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PHOSPHATES; PHOSPHORYLATION; PHOTORECEPTORS, VERTEBRATE; PROTEIN KINASE C; PROTEIN KINASES; RATS; RETINA; RHODOPSIN; RHODOPSIN KINASE; SERINE;

ANIMALIA;

EID: 0041761260     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030408     Document Type: Article

References (30)

1. Khorana, H. G. (1992) Rhodopsin, photoreceptor of the rod cell. J. Biol. Chem. 267, 1-4
2. Hargrave, P. A. and McDowell, J. H. (1992) Rhodopsin and phototransduction: a model system for G protein-linked receptors. FASEB J. 6, 2323-2331
3. Okada, T. and Palczewski, K. (2001) Crystal structure of rhodopsin: implications for vision and beyond. Curr. Opin. Struct. Biol. 11, 420-426
4. Kühn, H. (1978) Light-regulated binding of rhodopsin kinase and other proteins to cattle photoreceptor membranes. Biochemistry 17, 4389-4395
5. Wilden, U. and Kühn, H. (1982) Light-dependent phosphorylation of rhodopsin: number of phosphorylation sites. Biochemistry 21, 3014-3022
6. Palczewski, K., McDowell, J. H. and Hargrave, P. A. (1988) Purification and characterization of rhodopsin kinase. J. Biol. Chem. 263, 14067-14073
7. Palczewski, K., Buczylko, J., Kaplan, M. W., Polans, A. S. and Crabb, J. W. (1991) Mechanism of rhodopsin kinase activation. J. Biol. Chem. 266, 12949-12955
8. Lorenz, W., Inglese, J., Palczewski, K., Onorato, J. J., Caron, M. G. and Lefkowitz, R. J. (1991) The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the β-adrenergic receptor kinase. Proc. Natl. Acad. Sci. U.S.A. 88, 8715-8719
9. Pullen, N. and Akhtar, M. (1994) Rhodopsin kinase: studies on the sequence of and the recognition motif for multiphosphorylations. Biochemistry 33, 14536-14542
10. Ohguro, H., Palczewski, K., Ericsson, L. H., Walsh, K. A. and Johnson, R. S. (1993) Sequential phosphorylation of rhodopsin at multiple sites. Biochemistry 32, 5718-5724
11. McDowell, J. H., Nawrocki, J. P. and Hargrave, P. A. (1993) Phosphorylation sites in bovine rhodopsin. Biochemistry 32, 4968-4974
12. Newton, A. C. and Williams, D. S. (1993) Does protein kinase C play a role in rhodopsin desensitization? Trends Biochem. Sci. 18, 275-277
13. Newton, A. C. and Williams, D. S. (1991) Involvement of protein kinase C in the phosphorylation of rhodopsin. J. Biol. Chem. 266, 17725-17728
14. Newton, A. C. and Williams, D. S. (1993) Rhodopsin is the major in situ substrate of protein kinase C in rod outer segments of photoreceptors. J. Biol. Chem. 268, 18181-18186
15. Udovichenko, I. P., Newton, A. C. and Williams, D. S. (1997) Contribution of protein kinase C to the phosphorylation of rhodopsin in intact retinas. J. Biol. Chem. 272, 7952-7959
16. Greene, N. M., Williams, D. S. and Newton, A. C. (1995) Kinetics and localization of the phosphorylation of rhodopsin by protein kinase C. J. Biol. Chem. 270, 6710-6717
17. Greene, N. M., Williams, D. S. and Newton, A. C. (1997) Identification of protein kinase C phosphorylation sites on bovine rhodopsin. J. Biol. Chem. 272, 10341-10344
18. Ohguro, H., Johnson, R. S., Ericsson, L. E., Walsh, K. A. and Palczewski, K. (1994) Control of rhodopsin multiple phosphorylation. Biochemistry 33, 1023-1028
19. Kennedy, M. J., Lee, K. A., Niemi, G. A., Craven, K. B., Garwin, G. G., Saari, J. C. and Hurley, J. B. (2001) Multiple phosphorylation of rhodopsin and the in vivo chemistry underlying rod photoreceptor dark adaptation. Neuron 31, 87-101
20. Mendez, A., Burns, M. E., Roca, A., Lem, J., Wu, L. W., Simon, M. I., Baylor, D. A. and Chen, J. (2000) Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites. Neuron 28, 153-164
21. Papermaster, D. S. and Dreyer, W. J. (1974) Rhodopsin content in the outer segment membranes of bovine and frog retinal rods. Biochemistry 13, 2438-2444
22. Chen, C. K., Burns, M. E., Spencer, M., Niemi, G. A., Chen, J., Hurley, J. B., Baylor, D. A. and Simon, M. I. (1999) Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc. Natl. Acad. Sci. U.S.A. 96, 3718-3722
23. Liu, X., Udovichenko, I. P., Brown, S. D., Steel, K. P. and Williams, D. S. (1999) Myosin VIIa participates in opsin transport through the photoreceptor cilium. J. Neurosci. 19, 6267-6274
24. Ohguro, H., Van Hooser, J. P., Milam, A. H. and Palczewski, K. (1995) Rhodopsin phosphorylation and dephosphorylation in vivo. J. Biol. Chem. 270, 14259-14262
25. Lyubarsky, A. L., Chen, C., Simon, M. I. and Pugh, Jr, E. N. (2000) Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses. J. Neurosci. 20, 2209-2217
26. Zhou, X. Z., Kops, O., Werner, A., Lu, P. J., Shen, M., Stoller, G., Kullertz, G., Stark, M., Fischer, G. and Lu, K. P. (2000) Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins. Mol. Cell 6, 873-883
27. Nathans, J. and Hogness, D. S. (1983) Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin. Cell 34, 807-814
28. Baehr, W., Falk, J. D., Bugra, K., Triantafyllos, J. T. and McGinnis, J. F. (1988) Isolation and analysis of the mouse opsin gene. FEBS Lett. 238, 253-256
29. Barnstable, C. J. and Morabito, M. A. (1994) Isolation and coding sequence of the rat rod opsin gene. J. Mol. Neurosci. 5, 207-209
30. Nathans, J. and Hogness, D. S. (1984) Isolation and nucleotide sequence of the gene encoding human rhodopsin. Proc. Natl. Acad. Sci. U.S.A. 81, 4851-4855