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c) Recently we completed kinetic resolution of 5-pyrido-3-hydroxymethyl analog of Ia by Lipozym IM. Unreacted alcohol was obtained with 88% e.e at 52.5% conversion (E value 25), confirming that the substituent at (C3), not the basicity of pyridine unit control lipase catalyzed kinetic resolution.
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The authors are indebted to the referee who has drawn our attention to this mechanistic possibility.
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V. Š. is indebted to Prof. A. Antus, University of Debrecen, and to Prof. M. Simonyi, Institute of Chemistry, Hungarian Academy of Sciences, who have pointed to the ambiguity in the former nomencalture and suggested the modification presented here.
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