Molecular cloning and functional characterization of infectious PERV and development of diagnostic tests

Current Topics in Microbiology and Immunology

Volumn 278, Issue , 2003, Pages 217-237

  Niebert, M ^a   Tonjes R R ^a  

^a PAUL EHRLICH INSTITUT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; ENVELOPE PROTEIN;

ADAPTATION; ANTIGEN EXPRESSION; BREEDING; DIAGNOSTIC TEST; GENOME ANALYSIS; HOST CELL; HOST PATHOGEN INTERACTION; HUMAN; INFECTION RISK; LONG TERMINAL REPEAT; MICROCHIMERISM; MOLECULAR CLONING; NONHUMAN; ORGAN DONOR; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROVIRUS; RECIPIENT; RETROVIRUS; REVIEW; RISK ASSESSMENT; SEQUENCE ANALYSIS; SERODIAGNOSIS; SWINE; TRANSCRIPTION REGULATION; VACCINATION; VIRAL GENETICS; VIRUS DETECTION; VIRUS DIAGNOSIS; VIRUS REPLICATION; VIRUS TRANSMISSION; VIRUS VIRULENCE; XENOGRAFT; XENOTRANSPLANTATION;

ANIMALIA; PORCINE ENDOGENOUS RETROVIRUS; SUIDAE; SUS SCROFA; UNIDENTIFIED RETROVIRUS;

EID: 0041663573     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-55541-1_8     Document Type: Review

References (71)

1. Akiyoshi DE, Denaro M, Zhu H, Greenstein JL, Banerjee PT and Fishman JA (1998) Identification of a full-length cDNA for an endogenous retrovirus of miniature swine. J Virol 72:4503-4507
2. Bach FH, Ivinson AJ and Weeramantry HE (2001) Ethical and legal issues in technology: xenotransplantation. Am J Law Med 27:283-300
3. Bach FH, Robson SC, Winkler H, Ferran C, Stuhlmeier KM, Wrighton CJ and Hancock WW (1995). Barriers to xenotransplantation. Nat. Med. 1:869-873
4. Battini JL, Danos O and Heard JM (1995). Receptor-binding domain of murine leukemia virus envelope glycoproteins. J. Virol. 69:713-719
5. Battini JL, Rasko JEJ and Miller D (1999) A human cell-surface receptor for xenotropic and polytropic murine leukimia viruses: possible role in G-proteincoupled signal transduction. Proc. Natl. Acad. Sci. 96:1385-1390
6. Bennet W, Bjorkland A, Sundberg B, Brandhorst D, Brendel MD, Richards A, White DJ, Nilsson B, Groth CG and Korsgren O (2001) Expression of complement regulatory proteins on islets of Langerhans: a comparison between human islets and islets isolated from normal and hDAF transgenic pigs. Xenotransplantation 2:100-105
7. Bosch S, Arnould C and Jestin A (2000) Study of full-length porcine endogenous retrovirus genomes with envelope gene polymorphism in a specific-pathogen-free Large White swine herd. J Virol 74:8575-8581
8. Cappello F, Stassi G, Lazzereschi D, Renzi L, Di Stefano C, Marfe G, Giancotti P, Wang HJ, Stoppacciaro A, Forni M, Bacci ML, Turchi V, Sinibaldi P, Rossi M, Bruzzone P, Pretagostini R, Della Casa G, Cortesini R, Frati L and Lavitrano M (2000) hDAF expression in hearts of transgenic pigs obtained by sperm-mediated gene transfer. Transplant Proc 32:892-894
9. Carrington CA and dos Santos Cruz G (2000) Effect of cell surface concentration of human DAF on transgenic pig aortic endothelial cells on the degree of protection afforded against human complement deposition. Expert Opin Pharmacother 3:757-769
10. Clemenceau B, Jegou D, Martignat L and Sai P (2001) Long-term follow-up failed to detect in vitro transmission of full-length porcine endogenous retroviruses from specific pathogen-free pig islets to human cells. Diabetologia 44:2044-2055
11. Coffin JM (1984) Endogenous viruses. 2nd ed. In "RNA tumor viruses" (R. Weiss, N. Teich, H. Varmus, and J. Coffin, Eds.), pp. 1109-1203. Cold Spring Harbor Laboratory Press, New York.
12. rd ed; Edit.: Fields BN, Knipe DM, Howley PM et al. 1767-1847
13. Cornetta K, Moen RC, Culver K, Morgan RA, McLachlin JR, Sturm S, Selegue J, London W, Blaese RM and Anderson WF (1990) Amphotropic murine leukemia retrovirus is not an acute pathogen for primates. Hum Gene Ther 1:15-30
14. Czauderna F, Fischer N, Boller K, Kurth R and Tönjes RR (2000) Establishment and characterization of molecular clones of porcine endogenous retroviruses replicating on human cells. J. Virol. 74:4028-4038
15. Deng YM, Lee HJ, Moran C, Jin JH, Tuch BE and Rawlinson WD (2000) Mapping dispersed repetitive loci using semi-specific PCR cloning and somatic cell hybrid mapping. Nucleic Acid Res 28:E103
16. Echard G (1974) Chromosomal banding patterns and karyotype evolution in three pig kidney cell strains (PK15, F and RP). Chromosoma 45:133-49
17. Fischer N, Krach U, Niebert M and Tönjes RR (2003) Detection of porcine endogenous retrovirus (PERV) using highly specific antisera against Gag and Env. Virology (in press)
18. Fishman JA (1994). Miniature swine as organ donors for man: stratagies for prevention of xenotransplant-associated infections. Xenotransplantation 1:47-57
19. Fishman JA (1997) Xenosis and xenotransplantation: addressing the infectious risks posed by an emerging technology. Kidney Int. 51:41-45
20. Fox M and McHale J (1998) Xenotransplantation: the ethical and legal ramifications. Med Law Rev 6:42-61
21. Galbraith DN, Kelly HT, Dyke A, Reid G, Haworth C, Beekman J, Shepherd A and Smith KT (2000) Design and validation of immunological tests for the detection of Porcine endogenous retrovirus in biological materials. J Virol Methods 90:115-124
22. Gimbel W, Schmidt J, Brack-Werner R, Luz A, Strauss PG, Erfle V and Werner T (1996) Molecular and pathogenic characterization of the RFB osteoma virus: lack of oncogene and induction of osteoma, osteopetrosis, and lymphoma. Virology 224:533-538
23. Herring C, Cunningham DA, Whittam AJ, Fernandez-Suarez XM and Langford GA (2001a) Monitoring xenotransplant recipients for infection by PERV. Clin. Biochem. 34:23-27
24. Herring C, Quinn G, Bower R, Parsons N, Logan NA, Brawley A, Elsome K, Whittam A, Fernandez-Suarez XM, Cunningham D, Onions D, Langford G and Scobie L (2001b) Mapping full-length porcine endogenous retroviruses in a large white pig. J Virol 75:12252-12265
25. Hiasa A, Watanabe M, Okada H, Ikenaka K, Fujita T, Yoshimatsu T, Kanematsu T and Shiku H (1999) Retroviruses prepared from human DAF expressing murine packaging cells acquire resistance against human serum. Int J Oncol 14:1091-1096
26. Hunkeler D, Sun AM, Korbutt S, Rajotte RV, Gill RG, Calafiore R and Morel P (1999). Bioartificial organs and acceptable risk. Nature Biotechn. 17:1045
27. Krach U, Fischer N, Czauderna F and Tönjes RR (2001). Comparison of replication-competent molecular clones of porcine endogenous retrovirus class A and class B derived from pig and human cells. J Virol 75:5465-5472
28. Krach U, Fischer N, Czauderna F, Kurth R and Tönjes RR (2000) Generation and testing of a highly specific anti-serum directed against porcine endogenous retrovirus nucleocapsid. Xenotransplantation 7:1-10
29. Lai L, Kolber-Simonds D, KW Park, HT Cheong, JL Greenstein, GS Im, Samuel M, A Bonk, Rieke A, Day BN, Murphy CN, Carter DB, Hawley RJ and Prather RS (2002) Production of {alpha}-1,3-Galactosyltransferase Knockout Pigs by Nuclear Transfer Cloning. Science 295:1089-1092
30. Leibovitch MP, Leibovitch SA, Hillion J, Guillier M and Harel J (1987) Expression of C-type virus in non differentiating rat myoblasts correlates with neoplastic progression. Biochem Biophys Res Commun 142:1111-1119
31. LeTissier P, Stoye JP, Takeuchi Y, Patience C and Weiss RA (1997). Two sets of human-tropic pig retroviruses. Nature 389:681-682
32. Li M, Xu F, Muller J, Hearing VJ and Gorelik E (1998) Ecotropic C-type retrovirus of B16 melanoma and malignant transformation of normal melanocytes. Int J Cancer 76:430-436
33. Limjoco TI, Dickie P, Ikeda H and Silver J (1993) Transgenic Fv4 mice resistant to Friend virus. J Virol 67:4163-4168
34. Martin U, Kiessig V, Blusch JH, Haverich A, von der Helm K, Herden T and Steinhoff G (1998) Expression of pig endogenous retrovirus by primary porcine endothelial cells and infection of human cells. Lancet 352:692-694
35. Martiney MJ, Rulli K, Beaty R, Levy LS and Lenz J (1999) Selection of reversion and suppressors of a mutation in the CBF binding site of a lymphomagenic retrovirus. J Virol 73:7599-7606
36. Matthews AL, Brown J, Switzer W, Folks TM, Heneine W and Sandstrom PA (1999) Development and validation of a Western immunoblot assay for detection of antibodies to porcine endogenous retrovirus. Transplantation 67:939-943
37. Mayer J, Sauter M, Rácz A, Scherer D, Mueller-Lantzsch N and Meese E (1999) An almost-intact human endogenous retrovirus K on humanchromosome 7 Nature Genetics 21:257-258
38. Michaels MG and Simmons RL (1994) Xenotransplant-associated zoonoses. Transplantation 57:1-7
39. Miyagawa S, Tanemura M, Koyota S, Koma M, Ikeda Y, Shirakura R and Taniguchi N (1999) Masking and reduction of the Galactose-alpha1,3-Galactose (alpha-Gal) epitope, the major xenoantigen in swine, by the glycosyltransferase gene transfection. Biochem Biophys Res Commun 264:611-614
40. Niebert M, Rogel-Gaillard C, Chardon P and Tönjes RR (2002). Characterization of chromosomally assigned replication-competent gamma porcine endogenous retroviruses derived from a large white pig and expression in human cells. J Virol 76:2714-2720
41. Oldmixon BA, Wood JC, Ericsson TA, Wilson CA, White-Scharf ME, Andersson G, Greenstein JL, Schuurman HJ and Patience C (2002) PERV Transmission Characteristics of an Inbred Herd of Miniature Swine. J Virol 76: 3045-3048
42. Paradis K, Langford G, Long Z, Heneine W, Sandstrom P, Switzer WM, Chapman LE, Lockey C, Onions D, The XEN 111 Study Group and Otto E (1999). Search for cross-species transmission of porcine endogenous retrovirus in patients treated with liver pig tissue. Science 285:1236-1241.
43. Patience C, Switzer WM, Takeuchi Y, Griffiths DJ, Goward ME, Heneine W, Stoye JP and Weiss RA (2001). Multiple groups of novel retroviral genomes in pigs and related species. J Virol 75:2771-2775
44. Patience C, Takeuchi Y and Weiss RA (1997) Infection of human cells by an endogenous retrovirus of pigs. Nature Medicine 3:282-286
45. Pitkin Z and Mullon C (1999) Evidence of absence of porcine endogenous retrovirus (PERV) infection in patients treated with a bioartificial liver support system. Artif Organs 23:829-833
46. Powell SK, Gates ME, Langford G, Gu ML, Lockey C, Long Z and Otto E (2000) Antiretroviral agents inhibit infection of human cells by porcine endogenous retroviruses. Antimicrob. Agents Chemother. 44:3432-3433
47. Qari SH, Magre S, Garcia-Lerma JG, Hussain AI, Takeuchi Y, Patience C, Weiss RA and Heneine W (2001) Susceptibility of the porcine endogenous retrovirus to reverse transcriptase and protease inhibitors. J Virol 75:1048-1053
48. Reiss MJ (2000) The ethics of xenotransplantation. J Appl Philos 17:253-262
49. Rogel-Gaillard C, Bourgeaux N, Billault A, Vaiman M and Chardon P (1999) Construction of a swine BAC library: application to the characterization and mapping of the porcine type C endoviral elements. Cytogenet. Cell Genet. 85:205-211
50. Sandrin MS and McKenzie IF (1994) Gal alpha (1,3)Gal, the major xenoantigen(s) recognised in pigs by human natural antibodies. Immunol Rev 141:169-190
51. Sandrini MS, Fodor WL, Mouhtouris E, Osman N, Cohney S, Rollins SA, Guilmette ER, Setter E, Squinto SP and McKenzie IF (1995) Enzymatic remodelling of the carbohydrate surface of a xenogeneic cell substantially reduce human antibody binding and complement mediated cytolysis. Nature Medicine 1:1261-1267.
52. Scheef G, Fischer N, Krach U and Tönjes RR (2001) The number of a U3 repeat box acting as an enhancer in long terminal repeats of polytropic replication-competent porcine endogenous retroviruses dynamically fluctuates during serial virus passages in human cells. J Virol 75:6933-6940
53. Scheef G, Fischer N, Flory E, Schmitt I and Tönjes RR (2002) Transcriptional regulation of porcine endogenous retroviruses released from porcine and infected human cells by heterotrimeric protein complex NF-Y and impact of immunosuppressive drugs. J Virol 76:12553-12563
54. Stephan O, Schwendemann J, Specke V, Tacke SJ, Boller K and Denner J (2001) Porcine endogenous retroviruses (PERVs): generation of specific antibodies, development of an immunoperoxidase assay (IPA) and inhibition by AZT. Xenotransplantation 8:310-316
55. Stoye JP and Coffin JM (1995) The danger of xenotransplantation. Nature Medicine 1:1100
56. Tacke SJ, Bodusch K, Berg A and Denner J (2001) Sensitive and specific immunological detection methods for porcine endogenous retroviruses applicable to experimental and clinical xenotransplantation. Xenotransplantation 8:125-135
57. Takefman DM, Spear GT, Saifuddin M and Wilson CA (2002) Human CD59 incorporation into porcine endogenous retrovirus particles: Implications for the use of transgenic pigs for xenotransplantation. J Virol. 76:1999-2002.
58. Takefman DM, Wong S, Maudru T, Peden K and Wilson CA (2001) Detection and characterization of porcine endogenous retrovirus in porcine plasma and porcine factor VIII. J Virol 75:4551-4557
59. Takeuchi Y, Patience C, Magre S, Weiss RA, Banerjee PT, LeTissier P and Stoye JP (1998) Host range and interference studies of three classes of pig endogenous retrovirus. J. Virol. 72:9986-9991
60. Tönjes RR, Czauderna F and Kurth R (1999) Genome wide screening, cloning, chromosomal assignment and expression of full-length human endogenous retrovirus type K (HERV-K). J Virol 73:9187-9195
61. Tönjes RR, Czauderna F, Fischer N, Krach U, Boller K, Chardon P, Rogel-Gaillard C, Niebert M, Scheef G, Werner A and Kurth R (2000) Molecularly cloned porcine endogenous retroviruses replicate on human cells. Transplant Proc. 32:1158-1161
62. Tönjes RR, Löwer R, Boller K, Denner J, Hasenmaier B, Kirsch H, König H, Korbmacher C, Limbach C, Lugert R, Phelps RC, Scherer J, Thelen K, Löwer J and Kurth R (1996) HERV-K: the biologically most active human endogenous retrovirus family. J Acquir Immune Defic Syndr Hum Retrovirol 13:261-267
63. Turner G, Barbulescu M, Su M, Jensen-Seaman MI, Kidd KK and Lenz J (2001) Insertional polymorphisms of full-length endogenous retroviruses in humans. Curr Biol 11:1531-1535
64. Van der Laan LJW, Lockey C, Griffeth BC, Fraisier FS, Wilson CA, Onions DE, Hering BJ, Long Z, Otto E, Torbett BE and Salomon DR (2000) Infection by porcine en dogenous retrovirus after islet xenotransplantation in SCID mice. Nature 407:90-94
65. Venables PJW, Brookes SM, Griffiths D, Weiss RA and Boyd MT (1995) Abundance of an endogenous retroviral envelope protein in placental trophoblasts suggests a biological function. Virology 211:589-592
66. Weiss RA (1998) Transgenic pigs and virus adaptation. Nature 391:327-328
67. Weiss RA (2000) Ancient and modern retroviruses. Acta Microbiol Immunol Hung 47:403-410
68. Wilson CA, Wong S, Muller J, Davidson CE, Rose TM and Burd P (1998) Type C retrovirus released from porcine primary peripheral blood mononuclear cells infects human cells. J Virol 72:3082-3087
69. Wilson CA, Wong S, Van Brocklin M and Federspiel M (2000) Extended analysis of the in vitro tropism of porcine endogenous retrovirus. J Virol 74:49-56
70. Wolgamot G and Miller AD (1999) Replication of Mus dunni endogenous retrovirus depends on promoter activation followed by enhancer multimerization. J. Virol. 73:9803-9809
71. Woods T (1998) Have a heart: xenotransplantation, nonhuman death and human distress. Soc Anim 6:47-65