Skin penetration enhancement by the synergistic effect of supersaturated dissolution and chemical enhancers

Journal of Chemical Engineering of Japan

Volumn 36, Issue 1, 2003, Pages 92-97

  Wang, Qing ^a   Hikima, Tomohiro ^a   Tojo, Kakuji ^a  

^a KYUSHU INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Acrylic PSA; Chemical enhancer; Crystallization inhibitor; Supersaturated dissolution; Synergistic effect

Indexed keywords

ADHESIVES; CRYSTALLIZATION; DIFFUSION; SKIN;

CHEMICAL ENHANCERS;

CHEMICAL ENGINEERING;

MEDICAL APPLICATION;

EID: 0041626272     PISSN: 00219592     EISSN: None     Source Type: Journal    
DOI: 10.1252/jcej.36.92     Document Type: Article

References (17)

1. Arellano, A., S. Santoyo, C. Martin and P. Ygartua; "Influence of Propylene Glycol and Isopropyl Myristate on the in vitro Percutaneous Penetration of Diclofenac Sodium from Carbopol Gels," Eur. J. Pharm. Sci., 7, 129-135 (1999)
2. Iervolino, M., B. Cappello, S. L. Raghavan and J. Hadgraft; "Penetration Enhancement of Ibuprofen from Supersaturated Solutions through Human Skin," Int. J. Pharm., 212, 131-141 (2001)
3. Kim, H. J. and H. K. Choi; "Effect of Additives on the Crystallization and the Permeation of Ketoprofen from Adhesive Matrix," Inter. J. Pharm., 236, 81-85 (2002)
4. Lipp, R.; "Selection and Use of Crystallization Inhibitors for Matrix-type Transdermal Drug-Delivery Systems Containing Sex Steroids," J. Pharm. Pharmacol., 50, 1343-1349 (1998)
5. Ma, X. H., J. Taw and C. M. Chiang; "Control of Drug Crystallization in Transdermal Matrix System," Inter. J. Pharm., 142, 115-119 (1996)
6. Megrab, N. A., A. C. Williams and B. W. Barry; "Oestradiol Permeation through Human Skin and Silastic Membrane: Effects of Propylene Glycol and Supersaturation," J. Control. Rel., 36, 277-294 (1995)
7. Moser, K., K. Kriwet, Y. N. Kalia and R. H. Guy; "Enhanced Skin Permeation of a Llipophilic Drug Using Supersaturated Formulations," J. Control. Rel., 73, 245-253 (2001)
8. Naik, A., L. A. R. M. Pechtold, R. O. Potts and R. H. Guy; "Mechanism of Oleic Acid-Induced Skin Penetration Enhancement in vivo in Humans," J. Control. Rel., 37, 299-306 (1995)
9. Ogiso, T., M. Iwaki and T. Paku; "Effect of Various Enhancers on Transdermal Penetration of Indomethacin and Urea, and Relationship between Penetration Parameters and Enhancement Factors," J. Pharm. Sci., 84, 482-488 (1995a)
10. Ogiso, T., T. Paku, M. Iwaki and T. Tanino; "Percutaneous Penetration of Fluorescein Isothiocyanate-Dextrans and the Mechanism for Enhancement Effect of Enhancers on the Intercellular Penetration," Biol. Pharm. Bull., 18, 1566-1571 (1995b)
11. Raghavan, S. L., A. Trividic, A. F. Davis and J. Hadgraft; "Effect of Cellulose Polymers on Supersaturation and in vitro Membrane Transport of Hydrocortisone Acetate," Int. J. Pharm., 193, 231-237 (2000)
12. Schwarb, F. P., G. Imanidis, E. W. Smith, J. M. Haigh and C. Surber; "Effect of Concentration and Degree of Saturation of Topical Fluocinonide Formulations on in vitro Membrane Transport and in vivo Availability on Human Skin," Pharm. Res., 16, 909-915 (1999)
13. Taylor, L. S. and G. Zografi; "Spectroscopic Characterization of Interactions between PVP and Indomethacin in Amorphous Molecular Dispersions," Pharm. Res., 14, 1691-1698 (1997)
14. Tojo, K., C. C. Chiang and Y. W. Chien; "Drug Permeation across the Skin: Effect of Penetrant Hydrophilicity," J. Pharm. Sci., 76, 123-126 (1987)
15. Van Laarhoven, J. A. H., M. A. B. Kruft and H. Vromans; "Effect of Supersaturation and Crystallization Phenomena on the Release Properties of a Controlled Release Device Based on EVA Copolymer," J. Control. Rel., 82, 309-317 (2002)
16. Wang, Q., T. Hikima and K. Tojo; "Effect of Supersaturated Dissolution and Crystallization on in vitro Skin Penetration of 17-β-Estradiol from Acrylic Pressure Sensitive Adhesives," J. Chem. Eng. Japan, 35, 771-777(2002)
17. Yoshioka, M., B. C. Hancock and G. Zografi; "Inhibition of Indomethacin Crystallization in Poly(Vinylpyrrolidone) Coprecipitates," J. Pharm. Sci., 84, 983-986 (1995)