Perinatal lead exposure alters the expression of neuronal nitric oxide synthase in rat brain

International Journal of Toxicology

Volumn 20, Issue 3, 2001, Pages 113-120

  Chetty, C S ^a   Reddy, G R ^a   Murthy, K S ^b   Johnson, J ^a   Sajwan, K ^a   Desaiah, D ^c  

^a SAVANNAH STATE UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Cerebellum; Development; Hippocampus; Lead; Nitric oxide synthase

Indexed keywords

CALCIUM ION; LEAD; NITRIC OXIDE SYNTHASE;

ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CEREBELLUM; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME ACTIVITY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LONG TERM POTENTIATION; NONHUMAN; PREGNANCY; PRENATAL EXPOSURE; PROTEIN EXPRESSION; RADIOMETRY; RAT; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ANIMALS; BLOTTING, WESTERN; CEREBELLUM; FEMALE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LEAD; MALE; NEURONS; NITRIC OXIDE SYNTHASE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034944206     PISSN: 10915818     EISSN: None     Source Type: Journal    
DOI: 10.1080/109158101317097692     Document Type: Article

References (41)

1. Effect of lead acetate on nitrite production by murine brain endothelial cell culture
2. Nitric oxide synthase regulatory sites: Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites
3. Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of mammalian CNS together with NADPH diaphorase
4. Isolation of nitric oxide synthase, a calmodulin requiring enzyme
5. Mechanisms of lead neurotoxicity
6. Lead induced alterations in nitrite and nitrate levels in different regions of the rat brain
7. Mechanisms of Nitric oxide mediated neurotoxicity in primary brain cultures
8. Lead acetate exposure inhibits nitric oxide synthase activity in capillary and synaptosomal fractions of mouse brain
9. Glutamate, nitric oxide and cell-cell signaling in the nervous system
10. 2+ in calmodulin
11. The role of nitric oxide in hippocampal long-term potentiation
12. Correlation between lead-induced changes in cerebral ornithine decarboxylase and protein kinase C activities during development and in cultured PC 12 cells
13. Purkinje cells express neuronal nitric oxide synthase after methylmercury administration
14. Inhibition of nitric oxide synthase activity in rat brain by metals
15. Low-level subchronic exposure to lead does not affect nitric oxide synthase activity in rat frontal cortex
16. Lead activation of protein kinase C from rat brain
17. The effects of postnatal lead toxicity on the development of the cerebellum in rats
18. Picomolar concentrations of lead stimulate brain protein kinase C
19. Nitric oxide synthase structure and mechanism
20. Developmental changes in cytosolic and particulate nitric oxide synthase in rat brain
21. Port Pirie cohort study: Environmental exposure to lead and children's abilities at the age of four years
22. Effects of inorganic lead on levels of RNA, DNA and protein on developing neonatal rat brain
23. Issues of Pb toxicity
24. Developmental effects of lead: Its mechanism in intellectual functioning and neural plasticity
25. Differential experience following developmental lead exposure: Effects on brain and behavior
26. Early lead exposure and the hippocampus: A review and recent advances
27. Effects of lead exposure during development on neocortical dendritic and synaptic structure
28. Neuronal development in the cerebellum of lead poisoned normal rats
29. Lead inhibits calcium stimulated nitric oxide synthase activity from rat cerebellum
30. Modulation of protein kinase C by heavy metals
31. Pb-impaired neurodevelopment: Mechanisms and threshold values in the rodent
32. Chronic exposure to inorganic lead modifies protein kinase C activity and the distribution of its isozymes in the developing hippocampus
33. Nitric oxide synthase expression reveals compartment of cerebellar granuli cells and suggests a role for mossy fibers in their development
34. Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum
35. Chronic lead exposure in mature animals: Neurochemical correlates
36. Mechanisms of Pb neurotoxicity, or looking beyond the lamppost
37. Hyperactivity: A lead induced behavior disorder
38. Comparative observations in inorganic and organic Pb neurotoxicity
39. Exposure to lead-acetate modulates the developmental expression of myelin genes in the rat frontal lobe
40. SP1 as a target site for metal-induced perturbations of transcriptional regulation of developmental brain gene expression
41. Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hipppocampus