Effects of muscarinic receptor antagonists with or without M2 antagonist activity on cholinergic reflex bronchoconstriction in ovalbumin-sensitized and -challenged mice

Journal of Pharmacological Sciences

Volumn 92, Issue 3, 2003, Pages 209-217

  Hirose, Hiroyasu ^a   Jiang, Jian ^a   Nishikibe, Masaru ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Airway hyperresponsiveness; Bronchoconstriction; Compound A; Ipratropium; Muscarinic receptor antagonist

Indexed keywords

2 N [1 (6 AMINOPYRIDIN 2 YLMETHYL)PIPERIDIN 4 YL] 2 (3,3 DIFLUOROCYCLOPENTYL) 2 HYDROXY 2 PHENYLACETAMIDE; IPRATROPIUM BROMIDE; METHACHOLINE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M2 RECEPTOR ANTAGONIST; MUSCARINIC RECEPTOR BLOCKING AGENT; OVALBUMIN; SULFUR DIOXIDE; UNCLASSIFIED DRUG;

AIRWAY DYNAMICS; AIRWAY OBSTRUCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DISEASE EXACERBATION; DOSE RESPONSE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESPONSE; FEMALE; HISTOLOGY; INHIBITION KINETICS; LOW DRUG DOSE; MOUSE; NONHUMAN; OUTCOMES RESEARCH; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; REFLEX; RISK;

EID: 0041563916     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.92.209     Document Type: Article

References (26)

1. Hahn HL. Role of the parasympathetic nervous system and of cholinergic mechanisms in bronchial hyperreactivity. Bull Eur Physiol Respir. 1986;22 Suppl 7:112-142.
2. Thomas OC, McGovern JP. Air pollution and respiratory allergic disease. South Med J. 1972;65:1453-1458.
3. Witek TJ Jr, Schachter EN. Airway responses to sulfur dioxide and methacholine in asthmatics. J Occup Med. 1985;27:265-268.
4. Tan WC, Cripps E, Douglas N, Sudlow MF. Protective effect of drugs on bronchoconstriction induced by sulphur dioxide. Thorax. 1982;37:671-676.
5. Snashall PD, Baldwin C. Mechanisms of sulphur dioxide induced bronchoconstriction in normal and asthmatic man. Thorax. 1982;37:118-123.
6. Fryer AD, MacLagan J. Pancuronium and gallamine are antagonists for pre- and postjunctional muscarinic receptors in the guinea pig lung. Naunyn Schmiedebergs Arch Pharmacol. 1987;335:367-371.
7. 2 receptor. J Clin Invest. 1993;91:1314-1318.
8. 2 muscarinic receptors in antigen-challenged guinea pigs. J Clin Invest. 1997;100:2254-2262.
9. Costello RW, Evans CM, Yost BL, Belmonte KE, Gleich GJ, Jacoby DB, Fryer AD. Antigen-induced hyperreactivity to histamine: Role of the vagus nerves and eosinophils. Am J Physiol. 1999;276:L709-L714.
10. 2-sparing antagonistic activity. J Pharmacol Exp Ther. 2001;297:790-797.
11. 2-sparing antagonistic activity in guinea-pigs and mice airway tract. Jpn J Pharmacol. 2002;88 Suppl 1:229P.
12. Hamelmann E, Schwarze J, Takeda K, et al. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Respir Crit Care Med. 1997;156:766-775.
13. Djukanovic R, Roche WR, Wilson JW, et al. Mucosal inflammation in asthma. Am Rev Respir Dis. 1990;142:434-457.
14. Stewart AG, Tomlinson PR, Wilson J. Airway wall remodeling in asthma: A novel target for the development of anti-asthma drugs. Trends Pharmacol Sci. 1993;14:275-279.
15. Tanizaki Y, Kitani H, Okazaki M, Mifune T, Mitsunobu F, Kimura I. Mucus hypersecretion and eosinophils in bronchoalveolar lavage fluid in adult patients with bronchial asthma. J Asthma. 1993;30:257-262.
16. 2 receptors after the early allergic reaction: Possible contribution to bronchial hyperresponsiveness in allergic guinea-pigs. Br J Pharmacol. 1995;114:881-887.
17. 2 autoreceptors in vagally induced bronchoconstriction of conscious guinea pigs after the early allergic reaction. Eur J Pharmacol 1996;318:131-139.
18. Trifilieff A, El-Hashim A, Bertrand C. Time course of inflammatory and remodeling events in a murine model of asthma: Effect of steroid treatment. Am J Physiol. 2000;279:L1120-L1128.
19. Lammers JWJ, Minette P, McCusker M, Barnes PJ. The role of pirenzepine sensitive muscarinic receptors in vagally mediated bronchoconstriction in humans. Am Rev Respir Dis. 1989;139:446-449.
20. Yang KJ, Biggs DF. Muscarinic receptors and parasympathetic neurotransmission in guinea-pig trachea. Eur J Pharmacol 1991;193:301-308.
21. Brophy C, Ahmed B, Bayston S, Arnold A, McGivern D, Greenstone M. How long should Atrovent be given in acute asthma? Thorax. 1998;53:363-367.
22. Qureshi F, Pestian J, Davis P, Zaritsky A. Effects of nebulized ipratropium on the hospitalization rates of children with asthma. N Engl J Med 1998;339:1030-1035.
23. Rodrigo GJ, Rodrigo C. First-line therapy for adult patients with acute asthma receiving a multiple-dose protocol of ipratropium bromide plus albuterol in the emergency department. Am J Respir Crit Care Med. 2000;161:1862-1868.
24. Jacoby DB, Fryer AD. Anticholinergic therapy for airway diseases. Life Sci. 2000;68:2565-2572.
25. Mann JS, Howarth PH, Holgate TS. Bronchoconstriction induced by ipratropium bromide in asthma: Relation to hypotonicity. BMJ. 1984;289:469.
26. O'Callaghan C, Milner AD, Swarbrick A. Paradoxical bronchoconstriction in wheezing infants after nebulised preservative free iso-osmolar ipratropium bromide. BMJ. 1989;299:1433-1434.