Central and peripheral nervous system: Glycine transport inhibitors as potential antipsychotic drugs

Expert Opinion on Therapeutic Targets

Volumn 5, Issue 4, 2001, Pages 507-518

  Vandenberg, Robert J ^a   Aubrey, Karin R ^a  

^a University of Sydney   (Australia)

Author keywords

Glycine transport; Glycine transport inhibitors; GLYT1; NMDA receptor hypofunction; Schizophrenia

Indexed keywords

EID: 0041542278     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (68)

1. CROW TJ: The biology of schizophrenia. Experienta (1982) 38(11):1275-1282.
2. OLNEY JW, FARBER NB: Glutamate receptor dysfunction and schizophrenia [see comments]. Arch. Gen. Psychiatry (1995) 52(12):998-1007.
3. FARBER NB, NEWCOMER JW, OLNEY JW: Glycine agonists: what can they teach us about schizophrenia? [comment] Arch. Gin. Psychiatry (1999) 56(1):13-17.
4. REICH DL, SILVAY G: Ketaminc: an update on the first twenty-five years of clinical experience. Can. J. Anaesth. (1989) 36(2):186-97.
5. OLNEY JW, NEWCOMER JW, FARBER NB: NMDA receptor hypofunction model of schizophrenia. J. Psychiatr. Res. (1999) 33(6):523-533.
6. BENES FM: Altered glutamatergic and GABAergic mechanisms in the cingulate cortex of the schizophrenic brain. Arch. Gen. Psychiatry (1995) 52(12):1015-1018 (discussion 1019-1024).
7. HENN FA: The NMDA receptor as a site for psychopathology. Primary or secondary role? Arch. Gen. Psychiatry (1995) 52(12):1008-1010 (discussion 1019-1024).
8. CROW TJ: Constraints on concepts of pathogenesis. Language and the speciation process as the key to the etiology of schizophrenia [see comments]. Arch. Gen. Psychiatry (1995) 52(12):1011-104 (discussion 1019-1024).
9. OLNEY J, FARBER N: Response to commentaries and to the challenge of building a perfect theory to explain schizophrenia. Arch. Gen. Psychiatry (1995) 52(12):1019-1024.
10. MOHN AR, GAINETDINOV RR, CARON MG, KOLLER BH: Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell (1999) 98(4):427-436.
11. CORBETT R, CAMACHO F, WOODS AT et al.: Antipsychotic agents antagonize non-competitive N-methyl-D-aspartateN-methyl-D-aspartate antagonist-induced behaviors. Psychopharmacology (1995) 120(1):67-74.
12. MOGHADDAM B, ADAMS BW: Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats [see comments]. Science (1998) 281(5381):1349-1352.
13. GIROS B, JABER M, JONES SR, WIGHTMAN RM, CARON MG: Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature (1996) 379(6566):606-612.
14. MCBAIN CJ, MAYER ML: N-methyl-D-aspartic acid receptor structure and function. Physiol. Rev. (1994) 74(3):723-760.
15. HOLLMANN M, HEINEMANN S: Cloned glutamate receptors. Ann. Rev. Neurosci. (1994) 17:31-108.
16. DINGLEDINE R, BORGES K, BOWIE D, TRAYNELIS SF: The glutamate receptor ion channels. Pharmacol. Rev. (1999) 51(1):7-61.
17. IBRAHIM HM, HEALY DJ, HOGG AJ Jr., MEADOR-WOODRUFF JH: Nucleus-specific expression of ionotropic glutamate receptor subunit mRNAs and binding sites in primate thalamus. Brain Res. Mol. Brain Res. (2000) 79(1-2):1-17.
18. GAO XM, SAKAI K, ROBERTS RC, CONLEY RR, DEAN B, TAMMINGA CA: Ionotropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: effects of schizophrenia. Am. J. Psychiatry (2000) 157(7):1141-1149.
19. CORRE SL HARPER C, LOPEZ P, WARD P, CATTS S: Increased levels of expression of an NMDAR1 splice variant in the superior temporal gyrus in schizophrenia. Neuroreport (2000) 11(5):983-986.
20. GRIMWOOD S, SLATER P, DEAKIN J, HUTSON P: NR2B-containing NMDA receptors are upregulated in temporal cortex in schizophrenia. Neuroreport (1999) 10(3):461-465.
21. JOHNSON JW, ASCHER P: Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature (1987) 325(6104):529-531.
22. KLECKNER NW, DINGLEDINE R: Requirement for glycine in activation of NMDA receptors expressed in Xenopus oocytes. Science (1988) 241(4867):835-837.
23. BENVENISTE M, CLEMENTS J, VYKLICKY L Jr., MAYER ML: A kinetic analysis of the modulation of N-methyl-D-aspartic acid receptors by glycine in mouse cultured hippocampal neurones. J. Physiol. (1990) 428:333-357.
24. MAYER ML, VYKLICKY L Jr., CLEMENTS J: Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine. Nature (1989) 338(6214):425-427.
25. DURAND GM, BENNETT MV, ZUKIN RS: Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C. Proc. Natl. Acad. Sci. USA (1993) 90(14):6731-6735.
26. [published erratum appears in Proc. Natl. Acad. Sci. USA (1993) 90(20):9739]
27. DANYSZ W, PARSONS ACG: Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications. Pharmacol. Rev. (1998) 50(4):597-664.
28. KEW JN, RICHARDS JG, MUTEL V, KEMP JA: Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons. J. Neurosci. (1998) 18(6):1935-1943.
29. SMITH KE, BORDEN LA, HARTIG PR, BRANCHEK T, WEINSHANK RL: Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors Neuron (1992) 8(5):927-935.
30. KIM KM, KINGSMORE SF, HAN H et al.: Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes. Mol. Pharmacol. (1994) 45(4):608-617.
31. LIU QR, NELSON H, MANDIYAN S, LOPEZ-CORCUERA B, NELSON N: Cloning and expression of a glycine transporter from mouse brain. FEBS Lett. (1992)305(2):110-114.
32. LIU QR, LOPEZ-CORCUERA B, MANDIYAN S, NELSON H, NELSON N: Cloning and expression of a spinal cord-and brain-specific glycine transporter with novel structural features. J. Biol. Chem. (1993) 268(30):22802-22808.
33. GUASTELLA J, BRECHA N, WEIGMANN C, LESTER H A, DAVIDSON N: Cloning, expression, and localization of a rat brain high-affinity glycine transporter. Proc. Natl. Acad. Sci. USA (1992) 89(15):7189-7193.
34. HANLEY JG, JONES EM, MOSS SJ: GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1. J. Biol. Chem. (2000) 275(2):840-846.
35. PONCE J, POYATOS I, ARAGON C, GIMENEZ C, ZAFRA F: Characterization of the 5′ region of the rat brain glycine transporter GLVT2 gene: identification of a novel isoform. Neurosci. Lett. (1998) 242(1):25-28.
36. ZAFRA F, GOMEZA J, OLIVARES L, ARAGON C, GIMENEZ C: Regional distribution and developmental variation of the glycine transporters GLYT1 and gGLYT2 in the rat CNS. European J. Neurosci. (1995) 7(6):1342-1352.
37. ZAFRA F, ARAGON C, OLIVARES L, DANBOLT NC, GIMENEZ C, STORMMATHISEN J: Glycine transporters are differentially expressed among CNS cells. J. Neurosci. (1995) 15(5 Pt 2):3952-3969.
38. ROUX MJ, SUPPLISSON S: Neuronal and glial glycine transporters have different stoichiometries. Neuron (2000) 25:373-383.
39. BERGER S, CARTER J, LOWRY O: The distribution of glycine, gaba, glutamate and aspartate in rabbit spinal cord, cerebellum and hippocampus. J. Neurochem. (1977) 28:149-158.
40. ATTWELL D, BARBOUR B, SZATKOWSKI M: Nonvesicular release of neurotransmitter. Neuron (1993) 11(3):401-407.
41. BERGER AJ, DIEUDONNE S, ASCHER P: Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses. J. Neurophysiol. (1998) 80(6):3336-3340.
42. ROUX M, MARTINEZ-MAZA RA, LEGOFF B, LOPEZ-CORCUERA CA, SUPPLISSON S: The glial and the neuronal glycine transporters differ in their reactivity to sulfhydrl reagents. J. Biol. Chem. (2001) 276(21):17699-17705.
43. AUBREY KR, MITROVIC AD, VANDENBERG RJ: Molecular basis for proton regulation of glycine transport by GLYT1b. Mol. Pharmacol. (2000) 58(1):129-135.
44. ZAFRA F, ALCANTARA R, GOMEZA J, ARAGON C, GIMENEZ C: Arachidonic acid inhibits glycine transport in cultured glial cells. Biochem. J. (1990) 271(1):237-242.
45. NUNEZ E, LOPEZ-CORCUERA B, MARTINEZ-MAZA R, ARAGON C: Differential effects of ethanol on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters. Br. J. Pharmacol. (2000) 129(4):802-810.
46. WAZIRI R: Glycine therapy of schizophrenia [letter]. Biol. Psychiatry (1988)23(2):210-211.
47. ROSSE RB, THEUT SK, BANAY-SCHWARTZ M et al.: Glycine adjuvant therapy to conventional neuroleptic treatment in schizophrenia: an open-label, pilot study. Clin. Neuropharmacol. (1989) 12(5):416-424.
48. COSTA J, KHALED E, SRAMEK J, BUNNEY W Jr., POTKIN SG: An open trial of glycine as an adjunct to neuroleptics in chronic treatment-refractory schizophrenics. J. Clin. Psychopharmacol. (1990) 10(1):71-72.
49. JAVITT DC, ZYLBERMAN I, ZUKIN SR, HERESCO-LEVY U, LINDENMAYER JP: Amelioration of negative symptoms in schizophrenia by glycine: Am. J. Psychiatry (1994) 151(8):1234-1236.
50. HERESCO-LEVY U, JAVITT DC, ERMILOV M, MORDEL C, SILIPO G, LICHTENSTEIN M: Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia [see comments]. Arch. Gen. Psychiatry (1999) 56(1):29-36.
51. JAVITT D, HERESCO-LEVY U: Are glycine sites saturated in vivo. Arch. Gen. Psychiatry (2000) 57(12):1181-1182.
52. GREENE R, BERGERON R, MCCARLEY R, COYLE J, GRUNZE H: Short-term and long-term effects of N-methyl-D-aspartate receptor hypofunction. Arch. Gen. Psychiatry (2000) 57(12):1180-1181.
53. NAIR K, EPSTEIN I, BARON H, MULINOS M: Absorption, distribution, and excretion of cycloserine in man. Antibiot. Ann. (1956) 1956:136-140.
54. GOFF DC, TSAI G, MANOACH DS, COYLE JT: Dose-finding trial of D-cydoserine added to neuroleptics for negative symptoms in schizophrenia. Am. J. Pychiatry (1995) 152(8):1213-1215.
55. GOFF D C, TSAI G, MANOACH DS, FLOOD J, DARBY DG, COYLE JT: D-cycloserine added to clozapine for patients with schizophrenia. Am. J. Psychiatry (1996) 153(12):1628-1630.
56. VAN BERCKEL BN, HIJMAN R, VAN DER LINDEN JA, WESTENBERG H G, VAN REE J M, KAHN RS: Efficacy and tolerance of D-cydoserine in drug-free schizophrenic patients. Biol. Psychiatry (1996) 40(12):1298-1300.
57. GOFF DC TSAI G, LEVITT J et al.: A placebo-controlled trial of D-cydoserine added to conventional neuroleptics in patients with schizophrenia [see comments]. Arch. Gen. Psychiatry (1999) 56(1):21-27.
58. VAN BERCKEL BN, EVENBLIJ CN, VAN LOON BJ et al.: D-cydoserine increases positive symptoms in chronic schizophrenic patients when administered in addition to antipsychotics: a double-blind, parallel, placebo-controlled study. Neuropsychopharmacology (1999) 21(2):203-210.
59. MOTHET JP, PARENT AT, WOLOSKER H et al.: D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc. Natl. Acad. Sci. USA (2000) 97(9):4926-4931.
60. BARANANO D, FERRIS C, SNYDER S: Atypical neural messengers. Trends Neurosci. (2001) 24(2):99-106.
61. SCHELL MJ, BRADY RO, Jr., MOLLIVER ME, SNYDER SH: D-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors: J. Neurosci. (1997) 17(5):1604-1615.
62. NAKAUCHI J, MATSUO H, KIM DK et al.: Cloning and characterization of a human brain Na(+)-independenr transporter for small neutral amino acids that transports D-serine with high affinity. Neurosci. Lett. (2000) 287(3):231-235.
63. TSAI G, YANG P, CHUNG LC, LANGE N COYLE JT: D-serine added to antipsychotics for the treatment of schizophrenia [see comments]. Biol. Pychiatry (1998) 44(11):1081-1089.
64. TSAI GE, YANG P, CHUNG LC, TSAI IC, TSAI CW, COYLE JT: D-serine added to dozapine for the treatment of schizophrenia. Am. J. Psychiatry (1999) 156(11):1822-1825.
65. JAVITT DC, SERSHEN H, HASHIM A, LAJTHA A: Reversal of phencyclidine-induced hyperactivity by glycine and the glycine uptake inhibitor glycyldodecylamide. Neuropsychopharmacology (1997) 17(3):202-204.
66. JAVITT DC, FRUSCIANTE M: Glycyldodecylamide, a phencyclidine behavioral antagonist, blocks cortical glycine uptake: implications for schizophrenia and substance abuse. Psychopharmacology (1997) 129(1):96-98.
67. SUPPLISSON S, BERGMAN C: Control of NMDA receptor activation by a glycine transporter co-expressed in Xenopus oocytes. J. Neurosci. (1997) 17(12):4580-4590.
68. BERGERON R, MEYER TM, COYLE JT, GREENE RW: Modulation of N-methyl-D-asparrate receptor function by glycine transport. Proc. Natl. Acad. Sci. USA (1998) 95(26):15730-15734.