Analgesia from opioids: The complex relationship between drug dose and effect

Journal of Perianesthesia Nursing

Volumn 18, Issue 4, 2003, Pages 269-271

  Golembiewski, Julie A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTORPHANOL; CODEINE; CYTOCHROME P450; METHADONE; MIDAZOLAM; MORPHINE; NALBUPHINE; OPIATE; PHENYTOIN; RIFAMPICIN;

ANALGESIA; DOSE RESPONSE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EFFECT; DRUG ELIMINATION; DRUG INFUSION; DRUG POTENCY; DRUG TOXICITY; ENZYME ACTIVITY; GENETIC DIFFERENCE; HUMAN; NONHUMAN; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PAIN; SEX DIFFERENCE; SHORT SURVEY;

EID: 0041524009     PISSN: 10899472     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1089-9472(03)00135-7     Document Type: Article

References (11)

1. Wizemann T.M., Pardue M.L. Exploring the Biological Contributions to Human Health: Does Sex Matter? 2003;. Committee on Understanding the Biology of Sex and Gender Differences, Institute of Medicine, National Academy of Sciences, 2000. Available at http://www.nap.edu/books/0309072816/html . Accessed April 2003.
2. Kest B., Sarton E., Dahan A. Gender differences in opioid-mediated analgesia Animal and human studies . Anesthesiology. 93:2000;539-547.
3. Gear R.W., Miaskowski C., Gordon N.C., et al. Kappa-opioids produce significantly greater analgesia in women than in men. Nat Med. 11:1996;1248-1250.
4. Sarton E., Olofsen E., Romberg R., et al. Sex differences in morphine analgesia - an experimental study in healthy volunteers. Anesthesiology. 93:2000;1245-1254.
5. Chia Y.Y., Chow L.H., Hung C.C., et al. Gender and pain upon movement are associated with the requirements for postoperative patient-controlled IV analgesia A prospective survey of 2,298 Chinese patients . Can J Anesth. 49:2002;249-255.
6. Mogil J.S., Wilson S.G., Chesler E.J., et al. The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc Natl Acad Sci U S A. 100:2003;4867-4872.
7. Fromm M.F., Eckhardt K., Li S., et al. Loss of analgesic effect of morphine due to coadministration of rifampin. Pain. 72:1997;261-267.
8. Tong T.G., Pond S.M., Kreek M.J., et al. Phenytoin-induced methadone withdrawal. Ann Intern Med. 94:1981;349-351.
9. Williams D.G., Hatch D.J., Howard R.F. Codeine phosphate in paediatric medicine. Br J Anaesth. 86:2001;413-421.
10. Janicki P.K., Parris W.C. Clinical pharmacology of opioids. Smith H.S. Drugs for Pain. 2003;97-118 Hanley & Belfus, Philadelphia, PA.
11. Rogers J.P., Nafziger A.N., Bertino J.S. Pharmacogenetics affects dosing, efficacy, and toxicity of cytochromone P450-metabolizing drugs. Am J Med. 113:2002;746-750.