Transient early post-inoculation anti-retroviral treatment facilitates controlled infection with sparing of CD4+ T cells in gut-associated lymphoid tissues in SIV mac239-infected rhesus macaques, but not resistance to rechallenge

Journal of Medical Primatology

Volumn 32, Issue 4-5, 2003, Pages 201-210

  Lifson, Jeffrey D ^a   Piatak Jr , M ^a   Cline, A N ^a   Rossio, J L ^a   Purcell, J ^b   Pandrea, I ^b   Bischofberger, N ^c   Blanchard, J ^b   Veazey, R S ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

^c GILEAD SCIENCES   (United States)

Author keywords

CD8 depletion; HIV; Intestine; PMPA; SIV; T cell; Tenofovir

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; CD8 ANTIGEN; TENOFOVIR; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE MODEL; FOLLOW UP; IMMUNOPATHOGENESIS; INFECTION CONTROL; INOCULATION; INTESTINE LYMPHATIC TISSUE; LYMPHOCYTE DEPLETION; MALE; NONHUMAN; PERSISTENT INFECTION; PRIORITY JOURNAL; RHESUS MONKEY; RNA VIRUS INFECTION; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE; VIREMIA; VIRUS PATHOGENESIS; VIRUS RESISTANCE; VIRUS STRAIN;

ADENINE; ANIMALS; ANTI-HIV AGENTS; CD4-POSITIVE T-LYMPHOCYTES; DNA PRIMERS; GENE PRODUCTS, ENV; GENE PRODUCTS, GAG; INTESTINES; LYMPHOID TISSUE; MACACA MULATTA; MALE; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; RETROVIRIDAE PROTEINS, ONCOGENIC; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIRAL FUSION PROTEINS; VIRAL LOAD; VIREMIA;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; MACACA; MACACA MULATTA; RNA VIRUSES; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0041471518     PISSN: 00472565     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0684.2003.00026.x     Document Type: Article

References (21)

1. Hirsch VM, Lifson JD: Simian immunodeficiency virus infection of monkeys as a model system for the study of AIDS pathogenesis, treatment, and prevention. Adv Pharmacol 49:437-477, 2000.
2. Kestler H, Kodama T, Ringler D, Marthas M, Pedersen N, Lackner A, Regier D, Sehgal P, Daniel M, King N, Desrosiers R: Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus. Science 248:1109-1112, 1990.
3. Kumar A, Buch S, Foresman L, Bischofberger N, Lifson JD, Narayan O: Development of virus-specific immune responses in SHIV(KU)-infected macaques treated with PMPA. Virology 279:97-108, 2001.
4. Lifson JD, Rossio JL, Arnaout R, Li L, Parks TL, Schneider DK, Kiser RF, Coalter VJ, Walsh G, Imming RJ, Fisher B, Flynn BM, Bischofberger N, Piatak M Jr, Hirsch VM, Nowak MA, Wodarz D: Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment. J Virol 74:2584-2593, 2000.
5. Lifson JD, Rossio JL, Piatak M Jr, Parks T, Li L, Kiser R, Coalter V, Fisher B, Flynn BM, Czajak S, Hirsch VM, Reimann KA, Schmitz JE, Ghrayeb J, Bischofberger N, Nowak MA, Desrosiers RC, Wodarz D: Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment. J Virol 75:10187-10199, 2001.
6. Regier DA, Desrosiers RC: The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus. AIDS Res Hum Retroviruses 6:1221-1231, 1990.
7. Rosenwirth B, Ten Haaft P, Bogers WM, Nieuwenhuis IG, Niphuis H, Kuhn EM, Bischofberger N, Heeney JL, Uberla K: Antiretroviral therapy during primary immunodeficiency virus infection can induce persistent suppression of virus load and protection from heterologous challenge in rhesus macaques. J Virol 74:1704-1711, 2000.
8. Rossio JL, Esser MT, Suryanarayana K, Schneider DK, Bess JW Jr, Vasquez GM, Wiltrout TA, Chertova E, Grimes MK, Sattentau Q, Arthur LO, Henderson LE, Lifson JD: Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins. J Virol 72:7992-8001, 1998.
9. Schmitz JE, Kuroda MJ, Santra S, Sasseville VG, Simon MA, Lifton MA, Racz P, Tenner-Racz K, Dalesandro M, Scallon BJ, Ghrayeb J, Forman MA, Montefiori DC, Rieber EP, Letvin NL, Reimann KA: Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 283:857-860, 1999.
10. Suryanarayana K, Wiltrout TA, Vasquez GM, Hirsch VM, Lifson JD: Plasma SIV RNA viral load determination by real-time quantification of product generation in reverse transcriptase-polymerase chain reaction. AIDS Res Hum Retroviruses 14:183-189, 1998.
11. Tsai C-C, Follis KE, Sabo A, Beck TW, Grant RF, Bischofberger N, Benveniste RE, Black R: Prevention of SIV infection in macaques by (R)-9-(2-phosphonyl-methoxypropyl)adenine. Science 270:1197-1199, 1995.
12. Tsai CC, Emau P, Follis KE, Beck TW, Benveniste RE, Bischofberger N, Lifson JD, Morton WR: Effectiveness of postinoculation (R)-9-(2-phosphonyl-methoxypropyl) adenine treatment for prevention of persistent simian immunodeficiency virus SIVmne infection depends critically on timing of initiation and duration of treatment. J Virol 72:4265-4273, 1998.
13. Vajdy M, Veazey R, Tham I, Debakker C, Westmoreland S, Neutra M, Lackner A: Early immunologic events in mucosal and systemic lymphoid tissues after intrarectal inoculation with simian immunodeficiency virus. J Infect Dis 184:1007-1014, 2001.
14. Van Rompay KK, Marthas ML, Lifson JD, Berardi CJ, Vasquez GM, Agatep E, Dehqanzada ZA, Cundy KC, Bischofberger N, Pedersen NC: Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques. AIDS Res Hum Retroviruses 14:761-773, 1998.
15. Van Rompay KK, Dailey PJ, Tarara RP, Canfield DR, Aguirre NL, Cherrington JM, Lamy PD, Bischofberger N, Pedersen NC, Marthas ML: Early short-term 9-[2-(R)-(phosphonomethoxy)propyl]adenine treatment favorably alters the subsequent disease course in simian immunodeficiency virus-infected newborn rhesus macaques. J Virol 73:2947-2955, 1999.
16. Veazey RS, Demaria M, Chalifoux LV, Shvetz DE, Pauley DR, Knight HL, Rosenzweig M, Johnson RP, Desrosiers RC, Lackner AA: Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science 280:427-431, 1998.
17. Veazey RS, Mansfield KG, Tham IC, Carville AC, Shvetz DE, Forand AE, Lackner AA: Dynamics of CCR5 expression by CD4(+) T cells in lymphoid tissues during simian immunodeficiency virus infection. J Virol 74:11001-11007, 2000.
18. Veazey RS, Gauduin MC, Mansfield KG, Tham IC, Altman JD, Lifson JD, Lackner AA, Johnson RP: Emergence and kinetics of simian immunodeficiency virus-specific CD8(+) T cells in the intestines of macaques during primary infection. J Virol 75:10515-10519, 2001.
19. Veazey RS, Marx PA, Lackner AA: The mucosal immune system: primary target for HIV infection and AIDS. Trends Immunol 22:626-633, 2001.
20. Wodarz D, Page KM, Arnaout RA, Thomsen AR, Lifson JD, Nowak MA: A new theory of cytotoxic T-lymphocyte memory: implications for HIV treatment. Philos Trans R Soc Lond B 355:329-343, 2000.
21. Wodarz D, Arnaout RA, Nowak MA, Lifson JD: Transient antiretroviral treatment during acute simian immunodeficiency virus infection facilitates long-term control of the virus. Philos Trans R Soc Lond B 355:1021-1029, 2000.