Effects of dopexamine and positive end-expiratory pressure on intestinal blood flow and oxygenation: The perfusion pressure perspective

Chest

Volumn 124, Issue 2, 2003, Pages 688-698

  Lehtipalo, Stefan ^a   Biber, Björn ^a   Fröjse, Rolf ^a   Arnerlöv, Conny ^a   Johansson, Göran ^a   Winsö, Ola ^a  

^a UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Dopexamine; Lactate; Oxygen uptake; Positive end expiratory pressure; Splanchnic circulation; Swine

Indexed keywords

BARBITURIC ACID DERIVATIVE; DOPEXAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOREGULATION; BLOOD FLOWMETRY; BLOOD SAMPLING; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HYPOXEMIA; INTESTINE BLOOD FLOW; INTESTINE PRESSURE; LUNG COMPLIANCE; MESENTERY BLOOD FLOW; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN TISSUE LEVEL; PERFUSION PRESSURE; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PULSE OXIMETRY; SWINE; TISSUE OXYGENATION;

EID: 0041441167     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.124.2.688     Document Type: Article

References (47)

1. Gottrup F. Physiology and measurement of tissue perfusion. Ann Chir Gynaecol 1994; 83:183-189
2. Ruokonen E, Uusaro A, Alhava E, et al. The effect of dobutamine infusion on splanchnic blood flow and oxygen transport in patients with acute pancreatitis. Intensive Care Med 1997; 23:732-737
3. Vogt J, Reinelt H, Radermacher P. Dobutamine and the oxygen uptake/ supply relationship in sepsis: from global to regional; nothing is simple and easy. Intensive Care Med 1997; 23:715-717
4. Esen F, Telci L, Cakar N, et al. Evaluation of gastric intramucosal pH measurements with tissue oxygenation indices in patients with severe sepsis. Clin Intensive Care 1996; 7:180-189
5. Berendes E, Lippert G, Loick HM, et al. Effects of positive end-expiratory pressure ventilation on splanchnic oxygenation in humans. J Cardiothorac Vasc Anesth 1996; 10:598-602
6. Shoemaker WC, Appel PL, Kram HB, et al. Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. Chest 1988; 94:1176-1186
7. Ranieri VM, Mascia L, Fiore T, et al. Cardiorespiratory effects of positive end-expiratory pressure during progressive tidal volume reduction (permissive hypercapnia) in patients with acute respiratory distress syndrome. Anesthesiology 1995; 83:710-720
8. Dorinsky PM, Whitcomb ME. The effect of PEEP on cardiac output. Chest 1983; 84:210-216
9. Robotham JL, Cherry D, Mitzner W, et al. A re-evaluation of the hemodynamic consequences of intermittent positive pressure ventilation. Crit Care Med 1983; 11:783-793
10. Winsö O, Biber B, Gustavsson B, et al. Portal blood flow in man during graded positive end-expiratory pressure ventilation. Intensive Care Med 1986; 12:80-85
11. Tanaka S, Sagawa S, Miki K, et al. Changes in muscle sympathetic nerve activity and renal function during positive-pressure breathing in humans. Am J Physiol 1994; 266:R1220-R1228
12. De Backer D. The effects of positive end-expiratory pressure on the splanchnic circulation. Intensive Care Med 2000; 26:361-363
13. Suter PM, Fairley B, Isenberg MD. Optimum end-expiratory airway pressure in patients with acute pulmonary failure. N Engl J Med 1975; 292:284-289
14. Lehtipalo S, Biber B, Fröjse R, et al. Effects of PEEP on intestinal circulation during graded mesenteric artery occlusion. Acta Anaesthesiol Stand 2001; 45:875-884
15. Lee RD, Choe E, Flint L, et al. Neither dopamine nor dobutamine corrects mesenteric blood flow depression caused by positive end-expiratory pressure in a rat model of acute lung injury. Crit Care Med 1998; 26:1875-1880
16. Johnson DJ, Johannigman JA, Branson RD, et al. The effect of low dose dopamine on gut hemodynamics during PEEP ventilation for acute lung injury. J Surg Res 1991; 50:344-349
17. Brown RA, Dixon J, Farmer JB, et al. Dopexamine: a novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors. Br J Pharmacol 1985; 85:599-608
18. Fitton A, Benfield P. Dopexamine hydrochloride: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in acute cardiac insuffieiency. Drugs 1990; 39:308-330
19. Maard ND, Bihari DJ, Dalton RN, et al. Increasing splanchnic blood flow in the critically ill. Chest 1995; 108:1648-1654
20. Tighe D, Moss R, Haywood G, et al. Dopexamine hydrochloride maintains portal blood flow and attenuates hepatic ultrastructural changes in a porcine peritonitis model of multiple system organ failure. Circ Shock 1993; 39:199-206
21. Schmidt H, Seechi A, Wellmann R, et al. Dopexamine maintains intestinal villus blood flow during endotoxemia in rats. Crit Care Med 1996; 24:1233-1237
22. Steinberg S, Azar G, Love R, et al. Dopexamine prevents depression of mesenteric blood flow caused by positive end-expiratory pressure in rats. Surgery 1996; 120:597-601
23. Scheeren TWL, Sehwm-te LA, Loer SA, et al. Dopexamine but not dopamine increases gastric mucosal oxygenation during mechanical ventilation in dogs. Crit Care Med 2002; 30:881-887
24. Raner C, Biber B, Henriksson B-Å, et al. Effects of isoflurane on feline intetsiinal blood flow during hemorrhage-induced hypovolemia. Acta Anaesthesiol Scand 1986; 33:463-468
25. Sundeman H, Biber B, Raner C, et al. Antoregulation and vasodilator responses by isoflurane and desflurane in the feline renal vascular bed. Acta Anaesthesiol Scand 1997; 41:1180-1186
26. Lundgren O, Svanvik J. Mucosal hemodynamics in the small intestine of the cat during reduced perfusion pressure. Acta Physiol Scand 1973; 88:551-563
27. Meininger CA, Trzeciakowsld JP. Vasoconstriction is amplified by autoregulation during vasoconstrictor-induced hypertension. Am J Physiol 1988; 254:HT09-H718
28. Hannon JP, Bossone CA, Wade CE. Normal physiological values for conscious pigs used in biomedical research. Lab Anim Sci 1990; 40:293-298
29. Wheaton LG, Saar MG, Schlossberg L, et al. Gross anatomy of the splanchnic vasculatre. In: Granger DN, Bulkley GB, eds. Measurement of blood flow: applications to the splanchnic circulation. Baltimore, MD: Williams & Wilkins, 1981; 43-45
30. Ahn H, Lindhagen J, Nilsson GE, et al. Evaluation of laser Doppler flowmetry in the assessment of intestinal blood flow in cat. Gastroenterology 1985; 88:951-957
31. Kvietys PR, Shepherd AP, Granger DN. Laser-Doppler, H2 clearanee, and microsphere estimates of mucosal blood flow. Am J Physiol 1985; 249:G221-G227
32. Lundgren O. Microcirculation of the gastrointestinal tract and panereas. In: Renkin EM, Michel CC, eds. Handbook of physiology: the cardiovascular system (vol IV). Bethesda, MD: American Physiogical Society, 1984; 829-832
33. Folkow B. Intravascular pressure as a factor regulating the tone of small vessels. Acta Physiol Scand 1949; 17:289-316
34. Johnson PC. Myogenic nature of increase in intestinal vascular resistance with venous pressure elevation. Circ Res 1959; 6:992-999
35. Granger DN, Richardson PD, Kvietys PR, et al. Intestinal blood flow. Gastroenterology 1980; 78:837-863
36. Granger DN, Granger HJ. Systems analysis of intestinal hemodynamics and oxygenation. Am J Physiol 1983; 245:G786-G796
37. Desai TR, Sisley AC, Brown S, et al. Defining the critical limit of oxygen extraction in the human small intestine. J Vasc Surg 1996; 23:832-837
38. Hasibeder W, Germann R, Sparr H, et al. Vasomotion induces regular major oscillations in jejunal mucosal tissue oxygenation. Am J Physiol 1994; 266:G978-G986
39. Krejci V, Hiltebrand L, Banic A, et al. Continuous measurements of microcirculatory blood flow in gastrointestinal organs during acute haemorrhage. Br J Anaesth 2000; 84:468-475
40. Heino A, Hartikainen J, Merasto ME, et al. Systemic and regional effects of experimental gradual spIanchnic ischemia. J Crit Care 1997; 12:92-98
41. Sheridan WG, Lowndes RH, Williams GT, et al. Determination of a critical level of tissue oxygenation in acute intestinal isehaemia. Gut 1992; 33:762-766
42. Dorinsky PM, Whitcomb ME. The effect of PEEP on cardiac output. Chest 1983; 84:210-216
43. Robotham JL, Cherry D, Mitzner W, et al. A re-evaluation of the hemodyamic consequences of intermittent positive pressure ventilation. Crit Care Med 1983; 11:783-793
44. Sjovall H, Redfors S, Biber B, et al. Evidence for cardiac volume-receptor regulation of feline jejunal blood flow and fluid transport. Am J Physiol 1984; 246;G401-G410
45. Sellden H, Sjovall H, Ricksten SE. Sympathetic nerve activity and central haemo: dynamics during mechanical ventilation with positive end-expiratory pressure in rats. Acta Physiol Scand 1986; 127:51-60
46. Chernow B, Soldano S, Cook D, et al. Positive end-expiratory pressure increases plasma eatecholamine levels in non-volume loaded dogs. Anaesth Intensive Care 1986; 14:421-495
47. Aneman A, Eisenhofer G, Fandriks L, et al. Splanchnic circulation and regional sympathetic outflow during peroperative PEEP ventilation in humans. Br J Anaesth 1999; 82:838-842