Histopathological and immunohistochemical study of malignant transformation of oral leukoplakia, with special reference to apoptosis-related gene products and proliferative activity

Acta Oto-Laryngologica

Volumn 123, Issue 6, 2003, Pages 767-775

  Nogami, Toshio ^a   Kuyama, Kayo ^a   Yamamoto, Hirotsugu ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

Bax; Bcl 2; Ki 67; Oral pathology; p53; Precancerous lesions; Terminaldeoxynucleotide transferase mediated dUTP nick end labeling

Indexed keywords

GENE PRODUCT; KI 67 ANTIGEN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ADULT; AGED; APOPTOSIS; ARTICLE; CHEEK; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DYSPLASIA; FEMALE; GINGIVA; HEAD AND NECK DISEASE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEUKOPLAKIA; MALE; MALIGNANT TRANSFORMATION; NICK END LABELING; PRECANCER; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TONGUE; TUMOR SUPPRESSOR GENE;

EID: 0041425287     PISSN: 00016489     EISSN: None     Source Type: Journal    
DOI: 10.1080/00016480310000700b     Document Type: Article

References (31)

1. Pindborg JJ, Reichart PA, Smith CJ, van der Waal I. International histological classification of tumours: histological typing of cancer and precancer of the oral mucosa. Geneva, Switzerland: World Health Organisation; 1997.
2. Bouquot JE. Reviewing oral leukoplakia: clinical concepts for the 1990s. J Am Dent Assoc 1991; 122: 80-2.
3. Lind PO. Malignant transformation in oral leukoplakia. Scand J Dent Res 1987; 95: 449-55.
4. Hogewind WFC, van der Kwast WAM, van der Waal I. Oral leukoplakia, with emphasis on malignant transformation: a follow-up study of 46 patients. J Craniomaxillofac Surg 1989; 17: 128-33.
5. Pindborg JJ, Renstrup G, Jølst O, Roed-Petersen B. Studies in oral leukoplakia: a preliminary report on the period of prevalence of malignant transformation in leukoplakia based on a follow-up study of 248 patients. J Am Dent Assoc 1968; 76: 767-71.
6. Takagi M, Sakota Y, Ishikawa G. Histopathologic study of the squamous cell carcinoma of the oral mucosa. 1. Relationship between leukoplakia and invasive carcinoma. Kokubyo Gakkai Zasshi 1975; 42: 364-72.
7. Amagasa T, Totsuka M, Masuo K, Nagai J, Shimizu M, et al. Study on oral leukoplakia from the viewpoint of its clinical type, treatment and prognosis. J Oral Maxillofac Surg 1978; 24: 243-52.
8. Washizu K, Ono I, Ebihara S, Saito H, Majima K, et al. A study of oral precancerous lesions. Jpn J Cancer Clin 1981; 27: 942-7.
9. Inoue A, Sakamoto A, Uchida M, Kamata S. Malignant progression of oral leukoplakia - a long-term follow-up study. Jpn J Clin Oncol 1985; 20: 18-24.
10. Reed JC. Bcl-2 and the regulation of programmed cell death. J Cell Biol 1994; 124: 1-6.
11. Norris DA. Differential control of cell death in the skin. Arch Dermatol 1995; 131: 945-8.
12. Boise LH, González-García M, Postema CE, Ding L, Lindsten T, et al. Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 1993; 74: 597-608.
13. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-19.
14. Muraki Y, Yoshioka C, Fukuda J, Haneji T. Immunohistochemistry of Fas antigen - detection of Fas antigen in oral leukoplakia, lichen planus, and squamous cell carcinoma. J Oral Maxillofac Surg 1997; 43: 693-8.
15. Dekker NP, Lozada-Nur F, Lagenaur LA, MacPhail LA, Bloom CY, et al. Apoptosis-associated markers in oral lichen planus. J Oral Pathol Med 1997; 26: 170-5.
16. Birchall MA, Winterford CM, Allan DJ, Harmon BV. Apoptosis in normal epithelium, premalignant and malignant lesions of the oropharynx and oral cavity: a preliminary study. Eur J Cancer 1995; 31B: 380-3.
17. Birchall MA, Schock E, Harmon BV, Gobé G. Apoptosis, mitosis, PCNA and bcl-2 in normal, leukoplakic and malignant epithelia of the human oral cavity: prospective, in vivo study. Oral Oncol 1997; 33: 419-25.
18. Muraki Y, Yoshioka C, Fukuda J, Haneji T, Kobayashi N. Immunohistochemical detection of Fas antigen in oral epithelia. J Oral Pathol Med 1997; 26: 57-62.
19. Chrysomali E, Greenspan JS, Dekker N, Greenspan D, Regezi JA. Apoptosis-associated proteins in oral hairy leukoplakia. Oral Dis 1996; 2: 279-84.
20. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.
21. Burkhardt A. Advanced methods in the evaluation of premalignant lesions and carcinomas of the oral mucosa. J Oral Pathol Med 1985; 14: 751-78.
22. Verheijen R, Kuijpers HJH, Schlingeman RO, Boehmer ALM, van Driel R, et al. Ki-67 detects a nuclear matrix-associated proliferation-related antigen. 1. Intracellular localization during interphase. J Cell Sci 1989; 92: 123-30.
23. Liu SC, Klein-Szanto AJP. Markers of proliferation in normal and leukoplakic oral epithelia. Oral Oncol 2000; 36: 145-51.
24. Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, et al. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 1991; 352: 345-7.
25. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 1993; 362: 847-9.
26. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, et al. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 1993; 362: 849-52.
27. Lane DP. p53, guardian of the genome. Nature 1992; 358: 15-6.
28. Takahashi R, Inagaki T. p53-induced apoptosis. Exp Med 1995; 13: 42-4.
29. Dimitrakakis C, Kymionis G, Diakomanolis E, Papaspyrou I, Rodolakis A, et al. The possible role of p53 and bcl-2 expression in cervical carcinomas and their premalignant lesions. Gynecol Oncol 2000; 77: 129-36.
30. Wang LD, Zhou Q, Yang WC, Yang CS. Apoptosis and cell proliferation in esophageal precancerous and cancerous lesions: study of a high-risk population in Northern China. Anticancer Res 1999; 19: 369-74.
31. Morsi HM, Leers MPG, Radespiel-Tröger M, Björklund V, Kabarity HE, et al. Apoptosis, bcl-2 expression, and proliferation in benign and malignant endometrial epithelium: an approach using multiparameter flow cytometry. Gynecol Oncol 2000; 77: 11-7.