Distinct contributions of median raphe nucleus to contextual fear conditioning and fear-potentiated startle

Neural Plasticity

Volumn 9, Issue 4, 2002, Pages 233-247

  Silva, R C B ^c   Cruz, A P M ^a   Avanzi, V ^c   Landeira Fernandez, J ^b   Brandao M L ^c  

^a UNIVERSITY OF BRASILIA   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; AUTORECEPTOR; N METHYL DEXTRO ASPARTIC ACID; SEROTONIN; SEROTONIN 1A RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVERSIVE BEHAVIOR; BRAIN INJURY; CONDITIONING; CONTROLLED STUDY; ELECTROLYSIS; FEAR; FREEZING; MALE; MEDIAN RAPHE NUCLEUS; MICROINJECTION; NEUROTOXICITY; NONHUMAN; RAT; SHOCK; STARTLE REFLEX; STIMULUS RESPONSE; WHITE NOISE;

EID: 0041411240     PISSN: 20905904     EISSN: None     Source Type: Journal    
DOI: 10.1155/NP.2002.233     Document Type: Article

References (43)

1. Andrade TG, Graeff FG. 2001. Effect of electrolytic and neurotoxic lesions of the median raphe nucleus on anxiety and stress. Pharmacol Biochem Behav 70: 1-14.
2. Avanzi V, Castilho VM, de Andrade TG, Brandão ML. 1998. Regulation of contextual conditioning by the median raphe nucleus. Brain Res 790: 178-184.
3. Avanzi V, Brandão ML. 2001. Activation of somatodendritic 5-HT(1A) autoreceptors in the median raphe nucleus disrupts the contextual conditioning in rats. Behav Brain Res 126: 175-184.
4. Azmitia EC, Segal M. 1978. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J Comp Neurol 179: 641-667.
5. Blanchard DC, Blanchard RJ. 1972. Innate and conditioned reactions to threat in rats with amygdaloid lesions. J Comp Physiol Psychol 81: 281-290.
6. Blier P, de Montigny C. 1987 Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse 1: 470-480.
7. Bobillier P, Petijean F, Salvert D, Ligier M, Seguin S. 1975. Differential projections of the nucleus raphe dorsalis and nucleus raphe centralis as revealed by autoradiography. Brain Res 85: 205-210.
8. Bobillier P, Seguin S, Petitjean F, Salvert D, Touret M, Jouvet M. 1976. The raphe nuclei of the cat brain stem: a topographical atlas of their efferent projections as revealed by autoradiography. Brain Res 113: 449-486.
9. Brown JS, Kalish HI, Farber IE. 1951. Conditioned fear as revealed by magnitude of startle response to an auditory stimulus. J Exp Psychol 41: 317-328.
10. Campeau S, Davis M. 1995. Involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. J Neurosci 15: 2301-2311.
11. Davis M. 1992. The role of the amygdala in conditioned fear. In Aggleton JP, ed, The Amygdala: Neurobiological Aspects of Emotion, Memory and Mental Dysfunction. New York, NY, USA: Wiley-Liss, 255-305.
12. Davis M, Rainnie D, Cassell M. 1994. Neurotransmission in the rat amygdala related to fear and anxiety. Trends Neurosci 17: 208-214.
13. De Almeida RM, Giovenardi M, Charchat H, Lucion AB. 1998. 8-OH-DPAT in the median raphe nucleus decreases while in the medial septal area it may increase anxiety in female rats. Neurosci Biobehav Rev 23: 259-264.
14. Fanselow MS, Decola JP, De Oca BM, Landeira-Fernandez J. 1995. Ventral and dorsolateral regions of the midbrain periaqueductal gray (PAG) control different stages of defensive behavior: Dorsolateral PAG lesions enhance the defensive freezing produced by massed and immediate shock. Aggress Behav 21: 63-67.
15. Fanselow MS. 2000. Contextual fear, gestalt memories, and the hipoccampus. Behav Brain Res 110: 73-81.
16. Fendt M, Fanselow MS. 1999. The neuroanatomical and neurochemical basis of conditioned fear. Neurosci Biobehav Rev 23: 743-760.
17. Gewirtz JC, McNish KA, Davis M. 2000. Is the hippocampus necessary for contextual fear conditioning? Behav Brain Res 110: 83-95.
18. Geyer MA, Puerto A, Dawsey WJ, Knapp S, Bullard WP, Mandell AJ. 1976. Histologic and enzymatic studies of the mesolimbic and mesostriatal serotonergic pathways. Brain Res 106: 241-256.
19. Graeff FG, Silveira Filho NG. 1978. Behavioral inhibition induced by electrical stimulation of the median raphe nucleus of the rat. Physiol Behav 21, 477-484.
20. Gray JA. 1987. The Psychology of Fear and Stress. Cambridge, UK: Cambridge University Press.
21. Gray JA, McNaughton N. 2000. Fundamentals of the septo-hippocampal system. In: Gray JA, McNaughton N, eds, The Neuropsychology of Anxiety: An enquiry into the functions of septohippocampal system, 2nd edition. Oxford, UK: Oxford University press, 204-232.
22. Helmstetter FJ. 1992. The amygdala is essential for the expression of conditional hypoalgesia. Behav Neurosci 106: 518-528.
23. 1A agonist 8-OH-DPAT stimulates rat motor activity. Eur J Pharmacol 160: 303-307.
24. Hillegaart V. 1990. Effects of local application of 5-HT and 8-OH-DPAT into the dorsal and median raphe nuclei on motor activity in the rat. Physiol Behav 48: 143-148.
25. Hitchcock JM, Davis M. 1986. Lesions of amygdala, but not of the cerebellum or red nucleus, block conditioned fear as measured with the potentiated startle paradigm. Behav Neurosci 100: 11-22.
26. Kim JJ, Fanselow MS. 1992. Modality-specific retrograde amnesia of fear. Science 256(5057): 675-677.
27. Kiser RS, Lebovitz RM. 1975. Morroaminergic mechanisms in aversive brain stimulation. Physiol Behav 15: 47-53.
28. LeDoux JE, Iwata J, Cicchetti P, Reis DJ. 1988. Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear. J Neurosci 8: 2517-2529.
29. LeDoux JE. 1995. Emotion: clues from the brain. Ann Rev Psychol 46: 209-235.
30. Maren S, Aharonov G, Fanselow MS. 1997. Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats. Behav Brain Res 88: 261-274.
31. Maren S, Holt W. 2000. The hippocampus and contextual memory retrieval in Pavlovian conditioning. Behav Brain Res 110: 97-108.
32. McNish KA, Gewirtz JC, Davis M. 1997. Evidence of contextual fear after lesions of the hippocampus: a disruption of freezing but not fear-potentiated startle. J Neurosci 17: 9353-9360.
33. Molliver ME. 1987. Serotonergic neuronal systems: what their anatomic organization tells us about function. J Clin Psychopharmacol 7(Suppl): 3S-23S.
34. Melik E, Babar-Melik E, Ozgunen T, Binokay S. 2000. Median raphe nucleus mediates forming long-term but not short term contextual fear conditioning in rats. Behav Brain Res 112: 145-150.
35. Nieuwenhuys R. 1985. The Chemoarchitecture of the Brain. Berlin, Germany: Springer-Verlag; 33-41.
36. Papaioannou VE, Fox JG. 1993. Efficacy of tribromoethanol anesthesia in mice. Lab Anim Sci 43: 189-192.
37. Paxinos G, Watson C. 1997. The Rat Brain in Stereotaxic Coordinates, 3rd Edition. San Diego, California, USA: Academic Press.
38. Phillips RG, LeDoux JE. 1992. Differential contributions of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106: 274-285.
39. Phillips RG, LeDoux JE. 1994. Lesions of the dorsal hippocampal formation interfere with background but not foreground contextual fear conditioning. Learn Mem 1: 34-44.
40. Sananes CB, Davis M. 1992. N-methyl-D-aspartate lesions of the lateral and basolateral nuclei of the amygdala block fear-potentiated startle and shock sensitization of startle. Behav Neurosci 106: 72-80.
41. Srebro B, Lorens SA. 1975. Behavioral effects of selective midbrain raphe lesions in the rat. Brain Res 89: 303-325.
42. Tye NC, Everitt BJ, Iversen SD. 1977. 5-hydroxy-triptamine and punishment. Nature 268(5622): 741-743.
43. Vertes RP, Fortin WJ, Crane AM. 1999. Projections of the median raphe nucleus in the rat. J Comp Neurol 407: 555-582.