Chromosome 11 rearrangements and specific MLL amplification revealed by spectral karyotyping in a patient with refractory anaemia with excess of blasts (RAEB)

British Journal of Haematology

Volumn 122, Issue 5, 2003, Pages 760-763

  Calabrese, Giuseppe ^a,b   Fantasia, Donatella ^a,b   Morizio, Elisena ^a,b   Toro, Patrizia M ^a,b   Franchi, Paolo Guanciali ^a   Fornaro, Antonella ^b   Spadano, Antonio ^b   Stuppia, Liborio ^a,b   Palka, Giandomenico ^a,b  

^a UNIVERSITY OF CHIETI   (Italy)

^b CNR   (Italy)

Author keywords

MLL; Overexpression; Specific amplification; Spectral karyotyping

Indexed keywords

AGED; ARTICLE; CASE REPORT; CHROMATIN; CHROMOSOME ANALYSIS; CHROMOSOME REARRANGEMENT; DNA FLANKING REGION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; HUMAN; KARYOTYPING; MALE; PRELEUKEMIA; PRIORITY JOURNAL; PROGNOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AGED; ANEMIA, REFRACTORY, WITH EXCESS OF BLASTS; CHROMOSOMES, HUMAN, PAIR 11; DNA-BINDING PROTEINS; GENE AMPLIFICATION; GENE REARRANGEMENT; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; MALE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; PROTO-ONCOGENES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS;

EID: 0041411069     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04493.x     Document Type: Article

References (11)

1. Calabrese, G., Sallese, M., Stornaiuolo, A., Stuppia, L., Palka, G. & De Blasi, A. (1994) Chromosome mapping of the human arrestin (SAG), beta-arrestin 2 (ARRB2), and beta-adrenergic receptor kinase 2 (ADRBK2) genes. Genomics, 23, 286-288.
2. Calabrese, G., Min, T., Stuppia, L., Rowley, R., Swansbury, J.G., Morizio, E., Peila, R., Donti, E., Fioritoni, G. & Palka, G. (1996) Complex chromosome translocation of standard t(8;21) and t(15;17) arise from a two-step mechanism as evidenced by fluorescence in situ hybridization analysis. Cancer Genetics and Cytogenetics, 91, 40-45.
3. Cuthbert, G., Thompson, K., McCullough, S., Watmore, A., Dickinson, H., Telford, N., Mugneret, F., Harrison, C., Griffiths, M. & Bown, N. (2000) MLL amplification in acute leukemia: a United Kingdom Cancer Cytogenetics Group (UKCCG) Study. Leukemia, 4, 1885-1891.
4. Dolan, M., McGlennen, R.C. & Hirsch, B. (2002) MLL amplification in myeloid malignancies: clinical, molecular, and cytogenetic findings. Cancer Genetics and Cytogenetics, 134, 93-101.
5. Fidlerova, H., Senger, G., Kost, M., Sanseau, P. & Sheer, D. (1994) Two simple procedures for releasing chromatin from routinely fixed cells for fluorescence in situ hybridization. Cytogenetics and Cell Genetics, 65, 203-205.
6. Heim, S. & Mitelman, F. (1995) Cancer Cytogenetics, 2nd edn. Wiley-Liss, New York.
7. ISCN (1995) An International System for Human Cytogenetic Nomenclature (ed. by F. Mitelman). S. Karger, Basel.
8. Michaux, L., Wlodarska, I., Stul, M., Dierlamm, J., Mugneret, F., Herens, C., Beverloo, B., Verhest, A., Verellen-Dumoulin, C., Verhoef, G., Selleslag, D., Madoe, V., Lecomte, M., Deprijk, B., Ferrant, A., Delannoy, A., Marichal, S., Duhem, C., Dicato, M. & Hagemeijer, A. (2000) MLL amplification in myeloid leukemias: a study of 14 cases with multiple copies of 11q23. Genes Chromosomes and Cancer, 29, 40-47.
9. Peruzzi, D., Calabrese, G., Faenza, I., Manzoli, L., Matteucci, A., Gianfrancesco, F., Billi, A.M., Stuppia, L., Palka, G. & Cocco, L. (2000) Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta (1). Biochimica et Biophysica Acta, 1484, 175-182.
10. Rowley, J.D. (1999) The role of chromosome translocations in leukemogenesis. Seminars in Hematology, 36, 59-72.
11. Veldman, T., Vignon, C., Schrock, E., Rowley, J.D. & Ried, T. (1997) Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping. Nature Genetics, 15, 406-410.