Differential effects of interleukin-4 and interleukin-10 on nitric oxide production by murine macrophages

Inflammation Research

Volumn 48, Issue 12, 1999, Pages 643-650

  Nemoto, Y ^a   Otsuka, T ^a   Niiro, H ^a   Izuhara, K ^a   Yamaoka, K ^a   Nakashima, H ^a   Niho, Y ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

IL 10; IL 4; Nitric oxide (NO); Peritoneal macrophage

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FEMALE; IMMUNOREACTIVITY; IMMUNOREGULATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; FEMALE; INTERFERON-GAMMA, RECOMBINANT; INTERLEUKIN-10; INTERLEUKIN-4; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; NITRIC OXIDE; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033400106     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110050516     Document Type: Article

References (39)

1. [1] Fiorentino DE; Zlotnik A, Mosmann TR, Howard M, O'Garra A. IL-10 inhibits cytokine production by activated monocytes. J Immunol 1991; 147: 3815-22.
2. [2] de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174: 1209-20.
3. [3] Bogdan C, Vodovotz Y; Nathan C. Macrophage deactivation by interleukin 10. J Exp Med 1991; 174: 1549-55.
4. [4] Bogdan C, Paik J, Vodovotz Y, Nathan C. Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10. J Biol Chem 1992; 267: 23301-8.
5. [5] Kuga S, Otsuka T; Niiro H, Nunoi H, Nemoto Y, Nakano T et al. Suppression of superoxide anion production by interleukin-10 is accompanied with a downregulation of the genes for subunit proteins of NADPH oxidase. Exp Hematol 1996; 24: 151-7.
6. [6] Niiro H, Otsuka T, Kuga S, Nemoto Y, Abe M, Kara N, et al. IL-10 inhibits prostaglandin E2 production by lipopolysaccharide-stimulated monocytes. Int Immunol 1994; 6: 661-4.
7. [7] Cassatella MA, Meda L, Gasperini S, Calzetti F, Bonora S. Interleukin (IL)-10 upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation. J Exp Med 1994; 179: 1695-9.
8. [8] Hart PH, Vitti GF, Burgess DR, Whitty GA, Piccoli DS, Hamilton JA. Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2. Proc Natl Acad Sci USA 1989; 86: 3803-7.
9. [9] Niiro H, Otsuka T, Tanabe T; Hara S, Kuga S, Nemoto Y, et al. Inhibition by interleukin-10 of inducible cyclooxygenase expression in lipopolysaccharide-stimulated monocytes: Its underlying mechanism in comparison with interleukin-4. Blood 1995; 85: 3736-45.
10. [10] Niiro H, Otsuka T, Izuhara K, Yamaoka K, Ohshima K, Tanabe T, et al. Regulation by interleukin-10 and interleukin-4 of cyclooxygenase-2 expression in human neutrophils. Blood 1997; 89: 1621-8.
11. [11] Niiro H, Otsuka T, Ogami E, Yamaoka K, Nagano S, Akahoshi M, et al. MAP kinase pathways as a route for regulatory mechanisms IL-10 and IL-4 which inhibit COX-2 expression in human monocytes. Biochem Biophys Res Commun 1998; 250: 200-5.
12. [12] Tanaka Y, Otsuka T, Hotokebuchi T, Miyahara H, Nakashima H, Kuga S, et al. Effect of IL-10 on collagen-induced arthritis in mice. Inflamm Res 1996; 45: 283-8.
13. [13] Chomarat P, Banchereau J, Miosscc P. Differential effects of interleukins 10 and 4 on the production of interleukin-6 by blood and synovium monocytes in rheumatoid arthritis. Arthritis Rheum 1995; 38: 1046-54.
14. [14] Marfaing-Koka A, Maravic M, Humbert M, Galanaud F, Emilie D. Contrasting effects of IL-4, IL-10 and corticosteroids on RANTES production by human monocytes. Int Immunol 1996; 8: 1587-94.
15. [15] Auger MJ, Ross JA. The biology of the macrophage. In Lewis CE, McGee JOD (eds): The Macrophage. Oxford: Oxford University Press, 1992: 27-30.
16. [16] Hopper KE. Kinetics of macrophage recruitment and turnover in peritoneal inflammatory exudates induced by Salmonella or thioglycollate broth. J Leukoc Biol 1986; 39: 435-46.
17. [17] Melnicoff MJ, Horan PK, Morahan PS. Kinetics of changes in peritoneal cell populations following acute inflammation. Cell Immunol 1989; 118: 178-91.
18. [18] Oghiso Y; Yamada Y, ShibataY. Exudation of proliferative macrophages in local inflammation in the peritoneum. J Leukoc Biol 1992: 52:421-4.
19. [19] Kamdar SJ, Chapoval AI, Phelps J, Füller JA, Evans R. Differential sensitivity of mouse mononuclear phagocytes to CSF-1 and LPS: The potential in vivo relevance of enhanced IL-6 gene expression. Cell Immunol 1996; 174: 165-72.
20. [20] Shaw DR, Griffin FM Jr. Thioglycollate-elicited mouse peritoneal macrophages are less efficient than resident macrophages in antibody-dependent cell-mediated cytolysis. J Immunol 1982; 128: 433-40.
21. [21] Ding AH, Nathan CF, Stuehr DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol 1988; 141: 2407-12.
22. [22] Brabury MG, Moreno C. Effect of lipoarabinomannan and mycobacteria on tumour necrosis factor production by different populations of murine macrophages. Clin Exp Immunol 1993; 94: 57-63.
23. [23] Evans R, Kamdar SJ, Fuller JA, Krupke DM. The potential role of the macrophage colony-stimulating factor, CSF-1, in inflammatory responses: characterization of macrophage cytokine gene expression. J Leukoc Biol 1995; 58: 99-107.
24. [24] Nathan CF, Hibbs JB Jr. Role of nitric oxide synthesis in macrophage antimicrobial activity Current Opin. Immunol 1991; 3: 65-70.
25. [25] Oswald IP, Wynn TA, Sher A, James SL. Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor α required as a costimulatory factor for interferon γ-induced activation. Proc Natl Acad Sci USA 1992; 89: 8676-80.
26. [26] Gazzinelli RT, Oswald IP, James SL, Sher A. IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages. J Immunol 1992; 148: 1792-6.
27. [27] Gazzinelli RT, Oswald IP, Hieny S, James SL, Sher A. The microbicidal activity of interferon-gamma-treated macrophages against Trypanosoma cruzi involves an L-arginine-dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-beta. Eur J Immunol 1992; 22: 2501-6.
28. [28] Cunha FQ, Moncada S, Liew FY. Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages. Biochem Biophys Res Commun 1992; 182: 1155-9.
29. [29] Liew FY, Li Y, Severn A, Millott S, Schmidt J, Salter M, et al. A possible novel pathway of regulation by murine T helper type-2 (Th2) cells of a Th1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages. Eur J Immunol 1991; 21: 2489-94.
30. [30] al-Ramadi BK, Meissler JJ Jr, Huang D, Eisenstein TK. Immuno-suppression induced by nitric oxide and its inhibition by interleukin-4. Eur J Immunol 1992; 22: 2249-54.
31. [31] Oswald IP, Gazzinelli RT, Sher A, James SL. IL-10 synergizes with IL-4 and transforming growth factor-β to inhibit macrophage cytotoxic activity. J Immunol 1992; 148: 3578-82.
32. [32] Bogdan C, Vodovotz Y, Paik J, Xie QW, Nathan C. Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages. J Leukoc Biol 1994; 55: 227-33.
33. [33] Maru A, Jackson SK. Opposite effects of interleukin-4 and interleukin-10 on nitric oxide production in murine macrophages. Mediators Inflam 1996; 5: 110
34. [34] Corradin SB, Fasel N, Buchmuller-Rouiller Y, Ransijn A, Smith J, Mauel J. Induction of macrophage nitric oxide production by interferon-gamma and tumor necrosis factor-alpha is enhanced by interleukin-10. Eur J Immunol 1993; 23: 2045-8.
35. [35] Appelberg R. Opposing effects of interleukin-10 on mouse macrophage functions. Scand J Immunol 1995; 41: 539-44.
36. [36] O'Garra A, Chang R, Go N, Hastings R, Haughton G, Howard M. Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10. Eur J Immunol 1992; 22: 711-7.
37. [37] Hart PH, Ahern MJ, Jones CA, Jones KL, Smith MD, Finlay-Jones JJ. Synovial fluid macrophages and blood monocytes differ in their responces to IL-4. J Immunol 1993; 151: 3370-80.
38. [38] Erwig L-P, Kluth DC, Walsh GM, Rees AJ. Initial cytokine exposure determines function of macrophages and renders them unresponsive to other cytokines. J Immunol 1998; 161: 1983-8.
39. [39] DaMatta RA, Araujo-Jorge T, de Souza W. Subpopulations of mouse resident peritoneal macrophages fractionated on percoll gradients show differences in cell size, lectin binding and antigen expression suggestive of different stages of maturation. Tissue Cell 1995; 27: 505-13.