Life before birth: Effects of cortisol on future cardiovascular and metabolic function

Acta Paediatrica, International Journal of Paediatrics

Volumn 92, Issue 7, 2003, Pages 766-772

  Nathanielsz, Peter W ^a   Berghorn, K A ^b   Derks, J B ^c   Giussani, D A ^d   Docherty, C ^e   Unno, N ^f   Davenport, A ^d   Kutzler, M ^g   Koenen, S ^c   Visser, G H A ^c   Nijland, M J ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Obstetrics Gynecology   (United States)

^c UTRECHT UNIVERSITY   (Netherlands)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f UNIVERSITY OF TOKYO   (Japan)

^g OREGON STATE UNIVERSITY   (United States)

Author keywords

Blood pressure; Cardiovascular function; Fetal life; Fetal programming; Glucocorticoids; Thyroxine

Indexed keywords

BETAMETHASONE; DEXAMETHASONE; GLUCOCORTICOID; HYDROCORTISONE; LIOTHYRONINE; MEDROXYPROGESTERONE; THYROTROPIN; THYROXINE;

ARTERIAL BLOOD; ARTERIAL PRESSURE; BIRTH; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR SYSTEM; CONFERENCE PAPER; DRUG EFFECT; FETUS; FETUS DEVELOPMENT; HEMODYNAMIC MONITORING; LIFE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PREGNANCY; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; THYROXINE METABOLISM;

ANIMALS; CARDIOVASCULAR SYSTEM; EMBRYONIC AND FETAL DEVELOPMENT; ENDOTHELINS; FEMALE; FETAL BLOOD; FETAL DISEASES; HEART; HUMANS; HYDROCORTISONE; MATERNAL WELFARE; PAPIO; PERINATOLOGY; PREGNANCY; SHEEP; SOCIOECONOMIC FACTORS; THYROID GLAND; THYROTROPIN; THYROXINE;

EID: 0041373966     PISSN: 08035253     EISSN: None     Source Type: Journal    
DOI: 10.1080/08035250310003668     Document Type: Conference Paper

References (19)

1. Nathanielsz PW. Life before birth: the challenges of prenatal development. WH Freeman; 1998
2. Magyar DM, Fridshal D, Elsner CW, Glatz T, Eliot J, Klein AH, et al. Time-trend analysis of plasma cortisol concentrations in the fetal sheep in relation to parturition. Endocrinology 1980; 107: 155-9
3. Liggins GC. The role of cortisol in preparing the fetus for birth. Reprod Fert Dev 1994; 6: 141-50
4. Unno N, Wong CH, Jenkins SL, Wentworth RA, Ding XY, Li C, et al. Blood pressure and heart rate in the ovine fetus: ontogenic changes and effects of fetal adrenalectomy. Am J Physiol 1999; 276: H248-H56
5. Thomas AL, Krane EJ, Nathanielsz PW. Changes in the fetal thyroid axis after induction of premature parturition by low dose continuous intravascular cortisol infusion to the fetal sheep at 130 days of gestation. Endocrinology 1978; 103: 1723
6. Liggins GC, Howie RN. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. Pediatrics 1972; 50: 515-26
7. Derks JB, Giussani DA, Jenkins SL, Wentworth A, Visser GHA, Padbury JF, et al. A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep. J Physiol 1997; 449: 217-26
8. Wood CE, Cheung CY, Brace RA. Fetal heart rate, arterial pressure, and blood volume responses to cortisol infusion. Am J Physiol 1987; 253: R904-R9
9. Bennet L, Kozuma S, McGarrigle HHG, Hanson MA. Temporal changes in fetal cardiovascular, behavioural, metabolic and endocrine responses to maternally administered dexamethasone in the late gestation fetal sheep. Br J Obstet Gynaecol 1999; 106: 331-9
10. Koenen SV, Mecenas CA, Smith GC, Jenkins SL, Nathanielsz PW. Effects of maternal betamethasone administration on fetal and maternal BP and heart rate in the baboon at 0.7 of gestation. Am J Obstet Gynecol 2002; 186: 812-7
11. Docherty CC, Kalmar-Nagy J, Engelen M, Nathanielsz PW. Development of fetal vascular responses to endothelin-1 and acetylcholine in the sheep. Am J Physiol 2001; 280: R554-R62
12. Docherty CC, Kalmar-Nagy J, Engelen M, Koenen SV, Nijland MJ, Kuc RE, et al. Effect of in vivo fetal infusion of dexamethasone at 0.75 GA on fetal ovine resistance artery responses to ET-1. Am J Physiol Regul Integr Comp Physiol 2001; 281: R261-R8
13. Berghorn KA, Kalmar-Nagy J, Docherty C, Nijland MJ, Nathanielsz PW. Endothelin is involved in long-term programming of cardiovascular function following prenatal glucocorticoid administration. Biol Reprod 2000; 62 Suppl 1: 254 (Abstract 376)
14. MacMahon S, Peto R, Cutler J, Collins R, Sorlie P, Neaton J, et al. Blood pressure, stroke, and coronary heart disease. Part I. Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 1990; 335: 765-74
15. Kutzler MA, Molnar J, Kuc R, Davenport A, Nathanielsz PW. Maternal administration of dexamethasone increases endothelin-1 sensitivity and endothelin A receptor density in ovine fetal placental resistance arteries. Placenta 2003; 24: 392-402
16. Oh W, Gelardi NL, Cha CJM. The cross-generation effect of neonatal macrosomia in rat pups of streptozotocin-induced diabetes. Pediat Res 1991; 29: 606-10
17. Van Assche FA, Aerts L. Long-term effect of diabetes and pregnancy in the rat. Diabetes 1985; 34: 116-8
18. Nathanielsz PW. The Prenatal Prescription. New York: Harper Collins; 2001
19. Barker DJP. Mothers, babies and health in later life. 2nd ed. London: Churchill Livingstone; 1998