Cytokine modulating effect of ginseng treatment in a mouse model of Pseudomonas aeruginosa lung infection

Journal of Cystic Fibrosis

Volumn 2, Issue 3, 2003, Pages 112-119

  Song, Zhijun ^a   Moser, Claus ^a   Wu, Hong ^a   Faber, Viggo ^a   Kharazmi, Arsalan ^a   Høiby, Niels ^a  

^a University of Copenhagen   (Denmark)

Author keywords

Animal model; Cystic fibrosis; Cytokine; Ginseng; Pseudomonas aeruginosa

Indexed keywords

CONCANAVALIN A; CYTOKINE; GAMMA INTERFERON; GINSENG EXTRACT; INTERLEUKIN 4; MONOCLONAL ANTIBODY CD3; OUTER MEMBRANE PROTEIN; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYSTIC FIBROSIS; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; FEMALE; GRAM NEGATIVE INFECTION; HISTOPATHOLOGY; HOST PATHOGEN INTERACTION; IMMUNE RESPONSE; IMMUNOMODULATION; INCUBATION TIME; LUNG ALVEOLUS CELL; LUNG INFECTION; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PSEUDOMONAS AERUGINOSA; SPLEEN CELL; STATISTICAL ANALYSIS; TH1 CELL;

ANIMALS; CHI-SQUARE DISTRIBUTION; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; MICE; PANAX; PHYTOTHERAPY; PLANT EXTRACTS; PNEUMONIA, BACTERIAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; REGRESSION ANALYSIS; STATISTICS, NONPARAMETRIC;

EID: 0041358716     PISSN: 15691993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1569-1993(03)00065-1     Document Type: Article

References (39)

1. Hoiby N. Frederiksen B. Microbiology of cystic fibrosis In: Hodson M.E. Geddes D.M. editors. Cystic fibrosis 2000 83-107 Arnold London
2. Hoiby N. Krogh J.H. Moser C. Song Z. Ciofu O. Kharazmi A. Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth Microbes Infect 3 1 2001 23-35
3. Giwercman B. Jensen E.T. Hoiby N. Kharazmi A. Costerton J.W. Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm Antimicrob Agents Chemother 35 5 1991 1008-1010
4. Wu H. Song Z. Givskov M. et al. Pseudomonas aeruginosa mutations in lasI and rhlI quorum sensing systems result in milder chronic lung infection Microbiology 147 2001 1105-1113
5. Johansen H.K. Potential of preventing Pseudomonas aeruginosa lung infections in cystic fibrosis patients: experimental studies in animals APMIS Suppl 63 1996 5-42
6. Moser C. Kjaergaard S. Pressler T. Kharazmi A. Koch C. Hoiby N. The immune response to chronic Pseudomonas aeruginosa lung infection in cystic fibrosis patients is predominantly of the Th2 type APMIS 108 5 2000 329-335
7. Song Z. Kharazmi A. Wu H. et al. Effects of ginseng treatment on neutrophil chemiluminescence and immunoglobulin G subclasses in a rat model of chronic Pseudomonas aeruginosa pneumonia Clin Diagn Lab Immunol 5 6 1998 882-887
8. Song Z. Johansen H.K. Faber V. et al. Ginseng treatment reduces bacterial load and lung pathology in chronic Pseudomonas aeruginosa pneumonia in rats Antimicrob Agents Chemother 41 5 1997 961-964
9. Song Z. Johansen H.K. Faber V. Effects of subcutaneous injection with different doses of ginseng on the rat model of chronic Pseudomonas aeruginosa pneumonia Zhongguo Zhong Xi Yi Jie He Za Zhi 18 9 1998 546-549
10. Song Z.J. Johansen H.K. Faber V. Hoiby N. Ginseng treatment enhances bacterial clearance and decreases lung pathology in athymic rats with chronic P. aeruginosa pneumonia APMIS 105 6 1997 438-444
11. Govan J.R. Fyfe J.A. Baker N.R. Heterogeneity and reduction in pulmonary clearance of mucoid Pseudomonas aeruginosa Rev Infect Dis 5 Suppl 5 1983 S874-S879
12. Govan J.R. Fyfe J.A. Mucoid Pseudomonas aeruginosa and cystic fibrosis: resistance of the mucoid from to carbenicillin, flucloxacillin and tobramycin and the isolation of mucoid variants in vitro J Antimicrob Chemother 4 3 1978 233-240
13. Pedersen S.S. Shand G.H. Hansen B.L. Hansen G.N. Induction of experimental chronic Pseudomonas aeruginosa lung infection with P. aeruginosa entrapped in alginate microspheres APMIS 98 3 1990 203-211
14. Lange K.H. Hougen H.P. Hoiby N. Fomsgaard A. Rygaard J. Johansen H.K. Experimental chronic Pseudomonas aeruginosa lung infection in rats. Non-specific stimulation with LPS reduces lethality as efficiently as specific immunization APMIS 103 5 1995 367-374
15. Moser C. Hougen H.P. Song Z. Rygaard J. Kharazmi A. Hoiby N. Early immune response in susceptible and resistant mice strains with chronic Pseudomonas aeruginosa lung infection determines the type of T-helper cell response APMIS 107 12 1999 1093-1100
16. Moser C. Johansen H.K. Song Z. Hougen H.P. Rygaard J. Hoiby N. Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB/c mice compared to Th1 responding C3H/HeN mice APMIS 105 11 1997 838-842
17. Grimwood K. To M. Rabin H.R. Woods D.E. Inhibition of Pseudomonas aeruginosa exoenzyme expression by subinhibitory antibiotic concentrations Antimicrob Agents Chemother 33 1 1989 41-47
18. Johansen H.K. Espersen F. Cryz S.J. Jr. et al. Immunization with Pseudomonas aeruginosa vaccines and adjuvant can modulate the type of inflammatory response subsequent to infection Infect Immun 62 8 1994 3146-3155
19. Huang K.C. The pharmacology of Chinese herbs 1st ed 1993 CRC Press Inc Boca Raton
20. Liu C.X. Xiao P.G. Recent advances on ginseng research in China J Ethnopharmacol 36 1 1992 27-38
21. Doring G. Bellon G. Knight R. Immunology of cystic fibrosis In: Hodson M.E. Geddes D.M. editors. Cystic fibrosis 2000 109-140 Arnold London
22. Cripps A.W. Dunkley M.L. Clancy R.L. Kyd J. Pulmonary immunity to Pseudomonas aeruginosa Immunol Cell Biol 73 5 1995 418-424
23. Belardelli F. Role of interferons and other cytokines in the regulation of the immune response APMIS 103 3 1995 161-179
24. De Franco M. Gille-Perramant M.F. Mevel J.C. Couderc J. T helper subset involvement in two high antibody responder lines of mice (Biozzi mice): HI (susceptible) and HII (resistant) to collagen-induced arthritis Eur J Immunol 25 1 1995 132-136
25. Romagnani S. Th1/Th2 cells Inflamm Bowel Dis 5 4 1999 285-294
26. Infante-Duarte C. Kamradt T. Th1/Th2 balance in infection Springer Semin Immunopathol 21 3 1999 317-338
27. Mosmann T.R. Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more Immunol Today 17 3 1996 138-146
28. De Maeyer E. De Maeyer-Guignard J. Interferons In: Thomson A. editor. The cytokine handbook 1998 491-516 Academic Press San Diego
29. Liu J.H. Djeu J.Y. Role of cytokines in neutrophil functions In: Aggarwal B.B. Puri R.K. editors. Human cytokines: their role in disease and therapy 1995 71-86 Blackwell Science, Inc Cambridge
30. Song Z.J. Kharazmi A. Wu H. et al. Immunomodulatory properties of ginseng: effects on Pseudomonas aeruginosa lung infection Clin Microbiol Infect 5 1999 5S37-5S38
31. Lim D.S. Bae K.G. Jung I.S. Kim C.H. Yun Y.S. Song J.Y. Anti-septicaemic effect of polysaccharide from Panax ginseng by macrophage activation J Infect 45 1 2002 32-38
32. Yang J.P. Yang G.Z. Effects of ginsenoside on the central neuropeptide Y and catecholamines in amputation-stressed mice Chin J Immunol 9 1993 36-38
33. Yang G.Z. Bao T. Yu Y.L. Immunomodulating effects of ginsenoside in vivo and in vitro Commun Med Res 16 1987 220-221
34. See D.M. Broumand N. Sahl L. Tilles J.G. In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients Immunopharmacology 35 3 1997 229-235
35. Yun Y.S. Moon H.S. Oh Y.R. Jo S.K. Kim Y.J. Yun T.K. Effect of red ginseng on natural killer cell activity in mice with lung adenoma induced by urethane and benzo(a)pyrene Cancer Detect Prev Suppl 1 1987 301-309
36. Yun Y.S. Lee Y.S. Jo S.K. Jung I.S. Inhibition of autochthonous tumor by ethanol insoluble fraction from Panax ginseng as an immunomodulator Planta Med 59 6 1993 521-524
37. Kim J.Y. Germolec D.R. Luster M.I. Panax ginseng as a potential immunomodulator: studies in mice Immunopharmacol Immunotoxicol 12 2 1990 257-276
38. Shen L. Zhang J.T. Liu W. New evolvement on the study of ginseng enhancing immunity Traditional Chinese Herbal Med 27 1996 499-502
39. Johansen H.K. Hougen H.P. Rygaard J. Hoiby N. Interferon-gamma (IFN-gamma) treatment decreases the inflammatory response in chronic Pseudomonas aeruginosa pneumonia in rats Clin Exp Immunol 103 2 1996 212-218