Improving pharmacokinetic properties of adrenocorticotropin by site-specific lipid modification

Journal of Pharmaceutical Sciences

Volumn 92, Issue 9, 2003, Pages 1882-1892

  Wan, Lei ^a   Chen, Yu Hsien ^a   Chang, Tse Wen ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

ACTH; Albumin; Amino acid substitution; Half life; Hormones; Lipophilicity; Mutation; Peptides; Pharmacokinetics

Indexed keywords

CORTICOTROPIN; CYSTEINE; PHENYLALANINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CELL MEMBRANE; CHEMICAL MODIFICATION; CONJUGATION; CONTROLLED STUDY; DRUG HALF LIFE; DRUG METABOLISM; HALF LIFE TIME; HORMONE RELEASE; IN VITRO STUDY; LIPID ANALYSIS; LIPOPHILICITY; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; PROTEIN BINDING; SPECIFIC COMBINING ABILITY; STRUCTURE ACTIVITY RELATION;

EID: 0041336622     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10442     Document Type: Article

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