In vitro release of sodium diclofenac from a central core matrix tablet aimed for colonic drug delivery

European Journal of Pharmaceutical Sciences

Volumn 20, Issue 1, 2003, Pages 125-131

  González Rodríguez, María Luisa ^a   Maestrelli, Francesca ^b   Mura, Paola ^b   Rabasco, Antonio María ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Colonic targeting; Diclofenac; Emdex; Eudragit; Time controlled

Indexed keywords

DISSOLUTION; HYDROPHILICITY; PARTICLE SIZE ANALYSIS; POLYMERS; SODIUM;

COLONIC DRUG DELIVERY;

DRUG PRODUCTS;

DICLOFENAC; DRUG CARRIER; EMDEX; EUDRAGIT; EUDRAGIT RS; LACTOSE; MACROGOL 4000; POLYMER; SODIUM CHLORIDE; SOLVENT;

ARTICLE; COLON; CONTROLLED DRUG RELEASE; DISPERSION; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG FORMULATION; DRUG SOLUBILITY; HYDROPHILICITY; IN VITRO STUDY; KINETICS; MATRIX TABLET; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL; SOLID; TABLET COMPRESSION; TIME;

EID: 0041331746     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(03)00181-7     Document Type: Article

References (24)

1. Bussemer T., Otto I., Bodmeier R. Pulsatile drug-delivery systems. Pharm. Res. 17:2000;94-99.
2. Calatayud S., Warner T.D., Breese E.J., Mitchell J. Relationship between endogenous colony stimulating factors and apoptosis in human colon cancer cells: role of cyclo-oxygenase inhibitors. Br. J. Pharmacol. 134:2001;1237-1244.
3. Chavan M.S., Sant V.P., Nagarsenker M.S. Azo-containing urethane analogues for colonic drug delivery: synthesis, characterization and in vitro evaluation. J. Pharm. Pharmacol. 53:2001;895-900.
4. Dorkoosh F.A., Verhoef J.C., Borchard G., Rafiee-Tehrani M., Junginger H.E. Development and characterization of a novel peroral peptide drug delivery system. J. Control. Release. 71:2001;307-318.
5. Down G.R.B. Localized particle fracture during compression of materials expected to undergo plastic deformation. Powder Technol. 35:1983;167-169.
6. Fan T.Y., Wei S.L., Yan W.W., Chen D.B., Li J. An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets. J. Control. Release. 77:2001;245-251.
7. Fernández-Hervás M.J., Holgado M.A., Rabasco A.M., Fini A. Comportamiento en disolución de diferentes sales de diclofenaco (I) Estudio de solubilidad. Ind. Farm. 3:1995;83-87.
8. Gazzaniga A., Sangalli M.E., Giordano F., Zema L. Oral colon-specific drug delivery: design strategies. STP Pharma Prat. 4:(5):1994;336-343.
9. Gleiter C.H., Antonin K.H., Bieck P., Godbillon J., Schönleber W., Malchow H. Colonoscopy in the investigation of drug absorption in healthy volunteers. Gastrointest. Endosc. 31:1985;71-73.
10. González-Rodríguez M.L., Fernández-Hervás M.J., Caraballo I., Rabasco A.M. Design and evaluation of a new central core matrix tablet. Int. J. Pharm. 146:1997;175-180.
11. González-Rodríguez M.L., Pérez-Martínez J.I., Merino S.A., Fini A., Rabasco A.M. Channeling agent and drug release from a central core matrix tablet. Drug Dev. Ind. Pharm. 27:2001;439-446.
12. Junginger H.E. Oral applications of pulsatile drug delivery. Gurny R., Junginger H.E., Peppas N.A. Pulsatile Drug Delivery. Current Applications and Future Trends. 1993;113-134 Wissenschaftliche, Stuttgart.
13. Korsmeyer R.W., Gurny R., Doelker E., Buri P., Peppas N.A. Mechanisms of solute release from porous hydrophilic polymers. Int. J. Pharm. 15:1983;25-35.
14. Krishnaiah Y.S.R., Veer Raju P., Dinesh Kumar B., Bhaskar P., Satyanarayana V. Development of colon targeted drug delivery systems of mebendazole. J. Control. Release. 77:2001;87-95.
15. Krögel I., Bodmeier R. Floating or pulsatile drug delivery systems based on coated effervescent cores. Int. J. Pharm. 187:1999;175-184.
16. Maris B., Verheyden L., Van Reeth K., Samyn C., Augustijns P., Kinget R., Van den Mooter G. Synthesis and characterization of inulin-azo hydrogels designed for colon targeting. Int. J. Pharm. 213:2001;143-152.
17. Mrsny R.J. The colon as site for drug delivery. J. Control. Release. 22:(1):1992;15-34.
18. Munday D.L. Bimodal in vitro release from polymeric matrix tablets containing centralised drug cores. STP Pharma Sci. 6:1996;182-187.
19. Qiu L., Zhu K.J. Design of a core-shelled polymer cylinder for potential programmable drug delivery. Int. J. Pharm. 219:2001;151-160.
20. Rabasco, A.M., González-Rodríguez, M.L., Fernández-Hervás, M.J., Patent No. 9600385, 1996.
21. Sangalli M.E., Maroni A., Zema L., Busetti C., Giordano F., Gazzaniga A. In vitro and in vivo evaluation of an oral system for time and/or site-specific drug delivery. J. Control. Release. 73:2001;103-110.
22. Shotton E., Obiorah B.A. The effect of particle shape and crystal habit on properties of sodium chloride. J. Pharm. Pharmacol. 25:1973;37-43.
23. Tozer T.N., Friend D.R., McLeod A.D. Kinetic perspectives on colonic delivery. STP Pharma Sci. 5:1995;5-12.
24. Yeh P.Y., Berenson M.M., Samowitz W.S., Kopeckova P., Kopecek J. Site-specific drug delivery and penetration enhancement in the gastrointestinal tract. J. Control. Release. 36:1995;109-124.