Design and evaluation of a new central core matrix tablet

International Journal of Pharmaceutics

Volumn 146, Issue 2, 1997, Pages 175-180

  Gonzalez Rodriguez M L ^a   Fernandez Hervas M J ^a   Caraballo, I ^a   Rabasco, A M ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Controlled release; Inert matrix systems; Lag time; Programmed release; Zero order kinetic models

Indexed keywords

EUDRAGIT RS; METHYLENE BLUE; SODIUM CHLORIDE;

ARTICLE; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG RELEASE; KINETICS; MATRIX TABLET; PARTICLE SIZE; PRIORITY JOURNAL;

EID: 0343487696     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(96)04799-0     Document Type: Article

References (25)

1. Béchard, S. and McMullen, J.N., Solute release from a porous polymeric matrix: inwardly tapered disk with a central releasing hole. J. Pharm. Sci., 77 (1988) 222-228.
2. Benkorah, A.Y. and McMullen, J.N. Biconcave coated, centrally perforated tablets for oral controlled drug delivery. J. Control. Release, 32 (1994) 155-160.
3. Caraballo, I., Fernández-Arévalo, M., Holgado, M.A. and Rabasco, A.M., Percolation theory: application to the study of the release behavior from inert matrix systems. Int. J. Pharm., 96 (1993) 175-181.
4. Caraballo, I., Millán, M., Rabasco, A.M., Leuenberger, H., Zero-order release periods in inert matrices. Influence of the distance to the percolation threshold. Pharm. Acta Helv., (1996) in press.
5. 3 systems). J. Control. Release., 26 (1993) 39-47.
6. Fassihi, R.A. and Ritschel, W.A. Multiple-layer, direct-compression, controlled-release system: in vitro and in vivo evaluation. J. Pharm. Sci., 82 (1993) 750-754.
7. Fernández-Hervás, M.J., Aplicación de la teoría de la percolación y la geometría fractal al estudio del proceso de liberación en sistemas matriciales inertes. Tesis Doctoral, Facultad de Farmacia, Universidad de Sevilla, 1994.
8. Fernández-Hervás, M.J., Vela, M.T., Arias M.J. and Rabasco, A.M., Percolation theory: evaluation and interest of percolation threshold determination in inert matrix tablets. Pharm. Acta Helv., 71 (1996a) 259-264.
9. Fernández-Hervás, M.J., Vela, M.T., Caraballo, I. and Rabasco A.M., Effect of drug particle size on the release behaviour of NaCl-matrix systems. Eur. J. Pharm. Biopharm., 42 (3) (1996b) 208-211.
10. Fernández-Hervás, M.J., Vela, M.T., González-Rodríguez, M.L. and Rabasco, A.M., Use to the Percolation theory in to explain the release behaviour from inert matrix systems. Drug Dev. Ind. Pharm., 22 (1996c) 201-210.
11. Fernández-Hervás, M.J., Vela, M.T., Holgado, M.A., Del Cerro, J. and Rabasco, A.M., Determination of percolation thresholds in matrix-type controlled release systems: application of a resistance analysis technique. Int. J. Pharm., 113 (1995) 39-45.
12. Grosser, A.E., Fitzsimons, M. and Salha, J. Model for a controlled-release drug delivery safety system with permeable and erodible coatings. J. Pharm. Sci., 82 (1993) 1061-1063.
13. Gurny, R., Doelker, E. and Peppas, N.A., Modelling of sustained release of water-soluble drugs from porous, hydrophobic polymers. Biomaterials, 3 (1982) 27-32.
14. Higuchi, W.I. and Hiestand, E.N., Dissolution rates of finely divided drug powders I. Effect of a distribution of particle sizes in a diffusion controlled process. J. Pharm. Sci., 52 (1963) 67-71.
15. Higuchi, W.I., Rowe, E.L. and Hiestand, E.N., Dissolution rates of finely divided drug powders II. Micronized methylprednisolone. J. Pharm. Sci., 52 (1963) 162-164.
16. Hsieh, D.S.T., Rhine, W.D. and Langer, R. Zero-order controlled-release polymer matrices for micro- and macromolecules. J. Pharm. Sci., 72 (1983) 17-22.
17. Leuenberger, H. and Leu, R., Formation of a tablet: a site and bond percolation phenomenon. J. Pharm. Sci., 81 (1992) 976-981.
18. Leuenberger, H., Rohera, B.D. and Haas. C., Percolation theory - a novel approach to solid dosage form design, Int. J. Pharm., 38 (1987) 109-115.
19. Longer, M.A. and Robinson, J.R., Sustained-release drug delivery systems. In Gennaro, A.R. and Chase, G.D. (Eds), Remington's Pharmaceutical Sciences, 18th edn., Bonnie Brigham Packer, Philadelphia, 1990, pp. 1676-1686.
20. Makoid, M.C., Dufour, A. and Banakar, U.V., Modelling of dissolution behaviour of controlled release systems, S.T.P. Pharma, 3 (1993) 49-58.
21. Munday, D.L. Bimodal in vitro release from polymeric matrix tablets containing centralised drug cores. S.T.P. Pharma. Sci., 6 (1996) 182-187.
22. Peppas, N.A. and Ségot-Chicq S., Les dispositifs à libération contrôlée pour la délivrance des principes actifs médicamenteux. III. Modélisation des mecanismes diffusionnels. S.T.P. Pharma, 1 (1985) 208-216.
23. Potter, A., Proudfoot, S.G., Banks, M. and Aulton, M.E., Factors affecting dissolution-controlled drug release from a compacted dry powder mix. Proc. 6th Int. Conf. Pharm. Technol., Paris, 24 June 1992, pp. 90-99.
24. Ramos, M.T., Modelización de los procesos difusionales en sistemas matriciales inertes. An. Real Acad. Farm., 56 (1990) 201-210.
25. Stauffer, D., Introduction to Percolation Theory, Taylor and Francis, London, 1985, pp. 3-103.