Successful allogeneic neonatal bone marrow transplantation devoid of myeloablation requires costimulatory blockade

Journal of Immunology

Volumn 171, Issue 6, 2003, Pages 3270-3277

  Soper, Brian W ^a   Lessard, Mark D ^a   Jude, Craig D ^a   Schuldt, Adam J T ^a   Bunte, Ralph M ^a   Barker, Jane E ^a  

^a JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHIMERA; CONTROLLED STUDY; GRAFT FAILURE; GRAFT VERSUS HOST REACTION; GRAFT VERSUS LEUKEMIA EFFECT; HISTOLOGY; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; LYSOSOME STORAGE DISEASE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NEWBORN; NEWBORN CARE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0041331648     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.6.3270     Document Type: Article

References (50)

1. Sands, M. S., J. E. Barker, C. Vogler, B. Levy, B. Gwynn, N. Galvin, W. S. Sly, and E. Birkenmeier. 1993. Treatment of murine mucopolysaccharidosis type VII by syngeneic bone marrow transplantation in neonates. Lab. Invest. 68:676.
2. Blomberg, M., S. Rao, J. Reilly, C. Tiarks, S. Peters, E. Kittler, and P. Quesenberry. 1998. Repetitive bone marrow transplantation in nonmyeloablated recipients. Exp. Hematol. 26:320.
3. Rao. S. S., S. O. Peters, R. B. Crittenden, F. M. Stewart, H. S. Ramshaw, and P. J. Quesenberry. 1997. Stem cell transplantation in the normal nonmyeloablated host: relationship between cell dose, schedule, and engraftment. Exp. Hematol. 25:114.
4. Soper, B. W., M. D. Lessard, C. Vogler, B. Levy, W. G. Beamer, W. S. Sly, and J. E. Barker. 2001. Nonablative neonatal marrow transplantation attenuates functional and physical defects of β-glucuronidase deficiency. Blood 97:1498.
5. Neufeld, E. F., and J. Muenzer. 1995. The mucopolysaccharidoses. In Metabolic Basis of Inherited Disease. C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle. eds. McGraw-Hill. New York, p. 2465.
6. Birkenmeier, E. H., M. T. Davisson, W. G. Beamer, R. E. Ganschow, C. A. Vogler, B. Gwynn, K. A. Lyford, L. M. Maltias, and C. J. Wawrzyniak. 1989. Murine mucopolysaccharidosis type VII: characterization of a mouse with β-glucuronidase. J. Clin. Invest. 83:1258.
7. Wolfe, J. H., and M. S. Sands. 1996. Murine mucopolysaccharidosis type VII a model system for somatic gene therapy of the central nervous system. In Protocols for Gene Therapy in Neuroscience: Towards Gene Therapy of Neurological Disorders, P. R. Lowenstein and L. W. Enquist, eds. John Wiley & Sons. Chichester, p. 263.
8. Soper, B. W., T. M. Duffy, C. A. Vogler, and J. E. Barker. 1999. A genetically myeloablated MPS VII model detects the expansion and curative properties of as few as 100 enriched murine stem cells. Exp. Hematol. 27:1691.
9. Wekerle, T., J. Kurtz, H. Ito, J. V. Ronquillo, V. Dong, G. Zhao, J. Shaffer, M. H. Sayegh, and M. Sykes. 2000. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nat. Med. 6:464.
10. Durham, M. M., A. W. Bingaman, A. B. Adams, J. Ha, S. Y. Waitze, T. C. Pearson, and C. P. Larsen. 2000. Cutting edge: administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning. J. Immunol. 165:1.
11. Sayegh, M. H., and L. A. Turka. 1998. The role of T-cell costimulatory activation pathways in transplant rejection. N. Engl. J. Med. 338:1813.
12. Rossini, A. A., D. L. Greiner, and J. P. Mordes. 1999. Induction of immunologic tolerance for transplantation. Physiol. Rev. 79:99.
13. Sykes, M., M. A. Sheard, and D. H. Sachs. 1988. Graft-versus-host-related immunosuppression is induced in mixed chimeras by alloresponses against either host or donor lymphohematopoietic cells. J. Exp. Med. 168:2391.
14. Pelot, M. R., D. A. Pearson, K. Swenson, G. Zhao, J. Sachs, Y. G. Yang, and M. Sykes. 1999. Lymphohematopoietic graft-vs.-host reactions can be induced without graft-vs.-host disease in murine mixed chimeras established with a cyclophosphamide-based nonmyeloablative conditioning regimen. Biol. Blood Marrow Transplant. 5:133.
15. Blazar, B. R., P. A. Taylor, M. W. Boyer, A. Panoskaltsis-Mortari, J. P. Allison, and D. A. Vallera. 1997. CD28/B7 interactions are required for sustaining the graft-versus-leukemia effect of delayed post-bone marrow transplantation splenocyte infusion in murine recipients of myeloid or lymphoid leukemia cells. J. Immunol. 159:3460.
16. Johnson, B. D., W. R. Drobyski, and R. L. Truitt. 1993. Delayed infusion of normal donor cells after MHC-matched bone marrow transplantation provides an antileukemia reaction without graft-versus-host disease. Bone Marrow Transplant. 11:329.
17. Dazzi, F., R. M. Szydlo, and J. M. Goldman. 1999. Donor lymphocyte infusions for relapse of chronic myeloid leukemia after allogeneic stem cell transplant: where we now stand. Exp. Hematol. 27:1477.
18. Dazzi, F., R. M. Szydlo, N. C. Cross, C. Craddock, J. Kaeda, E. Kanfer, K. Cwynarski, E. Olavarria, A. Yong, J. F. Apperley, and J. M. Goldman. 2000. Durability of responses following donor lymphocyte infusions for patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukemia. Blood 96:2712.
19. Spitzer, T. R., S. McAfee, R. Sackstein, C. Colby, H. C. Toh, P. Multani, S. Saidman, D. W. Weyouth, F. Preffer, C. Poliquin, et al. 2000. Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies. Biol. Blood Marrow Transplant. 6:309.
20. Seung, E., N. Iwakoshi, B. A. Woda, T. G. Markees, J. P. Mordes, A. A. Rossini, and D. L. Greiner. 2000. Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versushost disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice, Blood 95:2175.
21. Yui, M. A., K. Muralidharan, B. Moreno-Altamirano, G Perrin, K. Chestnut, and E. K. Wakeland. 1996. Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits. Mamm. Genome 7:331.
22. Leiter, E. H. 1988. Control of spontaneous glucose intolerance, hyperinsulinemia, and islet hyperplasia in nonobese C3H.SW male mice by Y-linked locus and adrenal gland. Metabolism 37:689.
23. Sands, M. S., and J. E. Barker. 1999. Percutaneous intravenous injection in neonatal mice. Lab. Anim. Sci. 49:328.
24. Billingham, R. E., L. Brent, and P. B. Medawar. 1953. Actively acquired tolerance of foreign cells. Nature 172:603.
25. Eppig, J. J., L. P. Kozak, E. M. Eicher, and L. C. Stevens. 1977. Ovarian teratomas in mice are derived from oocyts that have completed the first meiotic division. Nature 269:517.
26. Eicher, E. M., and L. L. Washburn. 1978. Assignment of genes to regions of mouse chromosomes. Proc. Natl. Acad. Sci. USA 75:946.
27. Kruisbeek, A. M., and E. Shevack. 1991. Proliferative assays for T cell function, In Current Protocols in Immunology, Vol. 1. J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. John Wiley & Sons, New York, p. 3.12.1.
28. Hayashi, S., W. H. Peranteau, A. F. Shaaban, and A. W. Flake. 2002. Complete allogeneic hematopoietic chimerism achieved by a combined strategy of in utero hematopoietic stem cell transplantation and postnatal donor lymphocyte infusion. Blood 100:804.
29. Crooks, B. N., C. E. Taylor, A. J. Turner, H. K. Osman, M. Abinun, T. J. Flood. and A. J. Cant. 2000. Respiratory viral infections in primary immune deficiencies: significance and relevance to clinical outcome in a single BMT unit. Bone Marrow Transplant. 26:1097.
30. Griese, M., U. Rampf, D. Hofmann, M. Fuhrer, D. Reinhardt, and C. Bender-Gotze. 2000. Pulmonary complications after bone marrow transplantation in children: twenty-four years of experience in a single pediatric center. Pediatr. Pulmonol. 30:393.
31. Kist-Van Holthe, J. E., C. A. Goedvolk, R. Brand, M. H. Van Weel, R. G. Bredius, J. A. Van Oostayen, J. M. Vossen, and B. J. Van Der Heijden. 2002. Prospective study of renal insufficiency after bone marrow transplantation. Pediatr. Nephrol. 17:1032.
32. Locasciulli, A., M. Testa, M. G. Valsecchi, L. Vecchi, D. Longoni, P. Sparano, A. Rovelli, C. Uderzo, G. Masera, and A. Alberti. 1997. Morbidity and mortality due to liver disease in children undergoing allogeneic bone marrow transplantation: a 10-year prospective study. Blood 90:3799.
33. Adkins, B. 1999. T-cell function in newborn mice and humans. Immunol. Today 20:330.
34. Choi, E. Y., G. J. Christianson, Y. Yoshimura, N. Jung, T. J. Sproule, S. Malarkannan, S. Joyce, and D. C. Roopenian. 2002. Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease. Blood 100:4259.
35. Perreault, C., J. Jutras, D. C. Roy, J. G. Filep, and S. Brochu. 1996. Identification of an immunodominant mouse minor histocompatibility antigen (MiHA): T cell response to a single dominant MiHA causes graft-versus-host disease. J. Clin. Invest. 98:622.
36. Lu, C. Y., D. I. Beller, and E. R. Unanue. 1980. During ontogeny, la-bearing accessory cells are found early in the thymus but late in the spleen. Proc. Natl. Acad. Sci. USA 77:1597.
37. Marshall-Clarke, S., D. Reen, L. Tasker, and J. Hassan. 2000. Neonatal immunity: how well has it grown up? Immunol. Today 21:35.
38. Rossini, A. A., D. L. Greiner, and J. P. Mordes. 1999. Induction of immunologic tolerance for transplantation. Physiol. Rev. 79:99.
39. Grohmann, U., C. Orabona, F. Fallarino, C. Vacca, F. Calcinaro, A. Falorni, P. Candeloro, M. L. Belladonna, R. Bianchi, M. C. Fioretti, and P. Puccetti. 2002. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat. Immun. 3:1097.
40. Lee, R. S., J. R. Rusche, M. E. Maloney, D. H. Sachs, M. H. Sayegh, and J. C. Madsen. 2001. CTLA4Ig-induced linked regulation of allogeneic T cell responses. J. Immunol. 166:1572.
41. + thymocytes. Nature 333:742.
42. Wekerle, T., M. H. Sayegh, J. Hill, Y. Zhao, A. Chandraker, K. G. Swenson, G. Zhao, and M. Sykes. 1998. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J. Exp. Med. 187:2037.
43. Birkenmeier, E. H., J. E. Barker, C. A. Vogler, J. W. Kyle, W. S. Sly, B. Gwynn, B. Levy, and C. Pegors. 1991. Increased life span and correction of metobolic defects in murine mucopolysaccharidosis type VII after syngeneic bone marrow transplantation. Blood 78:3081.
44. Johnson, B. D., E. E. Becker, J. L. LaBelle, and R. L. Truitt. 1999. Role of immunoregulatory donor T cells in suppression of graft-versus-host disease following donor leukocyte infusion therapy. J. Immunol. 163:6479.
45. Kim, K. W., C. H. Yoon, C. S. Kay, H. J. Kim, K. S. Suh, S. Y. Kim, and S. Y. Park. 2003. Membranous nephropathy after allogeneic hematopoietic stem cell transplantation in a patient with aplastic anemia: a case report. J. Korean Med. Sci. 18:287.
46. Barbara, J. A., A. C. Thomas, P. S. Smith, D. Gillis, J. O. Ho, and A. J. Woodroffe. 1992. Membranous nephropathy with graft-versus-host disease in a bone marrow transplant recipient. Clin. Nephrol. 37, 115.
47. Yu, J., R. Cui, and S. Tong. 2001. Membranous nephropathy after allogeneic peripheral blood hematopoietic stem cell transplantation: clinicopathologic manifestations of a rare chronic GVHD, Zhonghua Xue Ye Xue Za Zhi. 22:415.
48. Sato, N., K. Kishi, K. Yagisawa, J. Kasama, R. Karasawa, H. Shimada, S. Nishi, M. Ueno, K. Ito, T. Koike, et al. 1995. Nephrotic syndrome in a bone marrow transplant recipient with chronic graft-versus-host disease. Bone Marrow Transplant. 16:303.
49. Hiesse, C., E. Goldschmidt, G. Santelli, B. Charpentier, D. Machover, and D. Fries. 1988. Membranous nephropathy in a bone marrow transplant recipient. Am. J. Kidney Dis. 11:188.
50. Lee, S. J., G. Vogelsang, and M. E. Flowers. 2003. Chronic graft-versus-host disease. Biol. Blood Marrow Transplant. 9:215.