Mammalian NADH diphosphatases of the Nudix family: Cloning and characterization of the human peroxisomal NUDT12 protein

Biochemical Journal

Volumn 374, Issue 2, 2003, Pages 329-335

  Abdelraheim, Salama R ^a   Spiller, David G ^a   McLennan, Alexander G ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Baculovirus; Nucleotide metabolism; Nudix hydrolase; Pyrophosphatase

Indexed keywords

AMINO ACIDS; CLONING; CYTOLOGY; PROTEINS;

CYTOPLASMIC STRUCTURES;

ENZYME KINETICS;

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; GREEN FLUORESCENT PROTEIN; HYDROLASE; MAGNESIUM ION; MANGANESE; NICOTINAMIDE NUCLEOTIDE; NUDT12 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; VIRUS VECTOR;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SUBSTRATE; HUMAN; MOLECULAR CLONING; PEROXISOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN TARGETING;

AMINO ACID SEQUENCE; AMYGDALA; ANIMALS; BACULOVIRIDAE; CELL LINE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PEROXISOMES; PYROPHOSPHATASES; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SPODOPTERA; SUBSTRATE SPECIFICITY;

INSECTA; MAMMALIA; UNIDENTIFIED BACULOVIRUS;

EID: 0041328588     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030441     Document Type: Article

References (26)

1. Bessman, M. J., Frick, D. N. and O'Handley, S. F. (1996) The MutT proteins or 'nudix' hydrolases, a family of versatile, widely distributed, 'housecleaning' enzymes. J. Biol. Chem. 271, 25059-25062
2. Dunn, C. A., O'Handley, S. F., Frick, D. N. and Bessman, M. J. (1999) Studies on the ADP-ribose pyrophosphatase subfamily of the Nudix hydrolases and tentative identification of trgB, a gene associated with tellurite resistance. J. Biol. Chem. 274, 32318-32324
3. McLennan, A. G. (1999) The MutT motif family of nucleotide phosphohydrolases in man and human pathogens. Int. J. Mol. Med. 4, 79-89
4. Caffrey, J. J., Safrany, S. T., Yang, X. N. and Shears, S. B. (2000) Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases - an expanding Nudt family. J. Biol. Chem. 275, 12730-12736
5. Leslie, N. R., McLennan, A. G. and Safrany, S. T. (2002) Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. BMC Biochem. 3, 20
6. Fisher, D. I., Safrany, S. T., Strike, P., McLennan, A. G. and Cartwright, J. L. (2002) Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. J. Biol. Chem. 277, 47313-47317
7. Safrany, S. T., Ingram, S. W., Cartwright, J. L., Falck, J. R., McLennan, A. G., Barnes, L. D. and Shears, S. B. (1999) The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase - overlapping substrate specificities in a MutT-type protein. J. Biol. Chem. 274, 21735-21740
8. Gasmi, L. and McLennan, A. G. (2001) The mouse Nudt7 gene encodes a peroxisomal nudix hydrolase specific for coenzyme A and its derivatives. Biochem. J. 357, 33-38
9. AbdelRaheim, S. and McLennan, A. G. (2002) The Caenorhabditis elegans Y87G2A.14 Nudix hydrolase is a peroxisomal coenzyme A diphosphatase. BMC Biochem. 3, 5
10. Cartwright, J. L., Gasmi, L., Spiller, D. G. and McLennan, A. G. (2000) The Saccharomyces cerevisiae PCD1 gene encodes a peroxisomal nudix hydrolase active towards coenzyme A and its derivatives. J. Biol. Chem. 275, 32925-32930
11. Frick, D. N. and Bessman, M. J. (1995) Cloning, purification, and properties of a novel NADH pyrophosphatase - evidence for a nucleotide pyrophosphatase catalytic domain in MutT-like enzymes. J. Biol. Chem. 270, 1529-1534
12. AbdelRaheim, S. R., Cartwright, J. L., Gasmi, L. and McLennan, A. G. (2001) The NADH diphosphatase encoded by the Saccharomyces cerevisiae NPY1 nudix hydrolase gene is located in peroxisomes. Arch. Biochem. Biophys. 388, 18-24
13. Xu, W. L., Dunn, C. A. and Bessman, M. J. (2000) Cloning and characterization of the NADH pyrophosphatases from Caenorhabditis elegans and Saccharomyces cerevisae, members of a Nudix hydrolase subfamily. Biochem. Biophys. Res. Commun. 273, 753-758
14. O'Reilly, D. R., Miller, L. K. and Luckow, V. A. (1992) Baculovirus Expression Vectors: A Laboratory Manual, W. H. Freeman, New York
15. 2+-dependent hydrolases acting on ADP-ribose. Biochim. Biophys. Acta 1246, 167-177
16. Lametschwandtner, G., Brocard, C., Fransen, M., van Veldhoven, P., Berger, J. and Hartig, A. (1998) The difference in recognition of terminal tripeptides as peroxisomal targeting signal 1 between yeast and human is due to different affinities of their receptor Pex5p to the cognate signal and to residues adjacent to it. J. Biol. Chem. 273, 33635-33643
17. Fraústo da Silva, J. J. R. and Williams, R. J. P. (2001) The Biological Chemistry of the Elements, 2nd edn, Oxford University Press, Oxford
18. Singh, A. K., Dobashi, K., Gupta, M. P., Asayama, K., Singh, I. and Orak, J. K. (1999) Manganese superoxide dismutase in rat liver peroxisomes: biochemical and immunochemical evidence. Mol. Cell. Biochem. 197, 7-12
19. Dobrzanska, M., Szurmak, B., Wyslouch-Cieszynska, A. and Kraszewska, E. (2002) Cloning and characterization of the first member of the Nudix family from Arabidopsis thaliana. J. Biol. Chem. 277, 50482-50486
20. de Hoop, M. J. and Ab, G. (1992) Import of proteins into peroxisomes and other microbodies. Biochem. J. 286, 657-669
21. Schrader, M., Baumgart, E., Volkl, A. and Fahimi, H. D. (1994) Heterogeneity of peroxisomes in human hepatoblastoma cell line HepG2. Evidence of distinct subpopulations. Eur. J. Cell Biol. 64, 281-294
22. Erdmann, R., Veenhuis, M. and Kunau, W. H. (1997) Peroxisomes: organelles at the crossroads. Trends Cell Biol. 7, 400-407
23. Johnston, J. A., Ward, C. L. and Kopito, R. R. (1998) Aggresomes: a cellular response to misfolded proteins. J. Cell Biol. 143, 1883-1898
24. Kopito, R. R. (2000) Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol. 10, 524-530
25. Meyerdierks, A., Denecke, B., Rohde, M., Taparowsky, E. J. and Böttger, E. C. (1999) A cytoplasmic structure resembling large protein aggregates induced by interferons. J. Histochem. Cytochem. 47, 169-182
26. Sedgwick, S. G. and Smerdon, S. J. (1999) The ankyrin repeat: a diversity of interactions on a common structural framework. Trends Biochem. Sci. 24, 311-316