Effect of WT1 gene expression on cell growth and proliferation in myeloid leukemia cell lines

Chinese Medical Journal

Volumn 112, Issue 8, 1999, Pages 705-708

  Mi, Yingchang ^a   Wang, Li ^a   Bian, Shougeng ^a   Meng, Qingxiang ^a   Chen, Guibin ^a   Wang, Jianxiang ^a  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

Author keywords

Antisense oligonudeotide; Apoptosis; Leukemia, myeloid; Proliferation; WT1 gene

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; WT1 PROTEIN;

APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL DIVISION; CELL STRAIN HL 60; CELL STRAIN K 562; GENE EXPRESSION; HUMAN; PATHOLOGY; PROTO ONCOGENE; TUMOR SUPPRESSOR GENE;

APOPTOSIS; CELL DIVISION; GENE EXPRESSION; GENES, BCL-2; GENES, P53; GENES, WILMS TUMOR; HL-60 CELLS; HUMANS; K562 CELLS; OLIGONUCLEOTIDES, ANTISENSE; WT1 PROTEINS;

EID: 0040886289     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Call M, Glaser T, Ito Y, et al. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms tumor locus. Cell 1990;60:509-515.
2. Haber A, Sohn L, Buckler J, et al. Alternative splicing and genomic structure of the Wilms' tumor gene WT1. Proc Natl Acad Sci U S A 1991;88:9618-9622.
3. Hewitt M, Hamada S, Mcdonnell J, et al. Regulation of the protoonco-genes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res 1995;55:5386-5389.
4. Maheswaran S, Englert C, Bennett P, et al. The WT1 gene product sta-blizes P53 and inhibits P53-mediated apoptosis. Genes Dev 1995;9:2143-2156.
5. Bergmann L, Miething C, Maurer U, et al. High levels of Wilms' tumor gene (WT1) mRNA in acute myeloid leukemias associated with a worse long-term outcome. Blood 1997;90:1217-1225.
6. Barbara GC, John P, Peter R, et al. Use of the MTT assay for rapid determination of chemosensitivity of human leukemic blast cells. Leuk Res 1988;12:823.
7. Brenner B, Wildhardt G, Schneider S, et al. RNA polymerase chain reaction detects different levels of four alternatively spliced WT1 transcripts in Wilms' tumors. Oncogene 1992;7:1431-1433.
8. Albitar M, Peschle C, Liebhaber A. Theta, Zeta and Epsilon globin messenger RNAs are expressed in adults. Blood 1989;74:629-637.
9. Finke J, Fritzen R, Ternes P, et al. Expression of bcl-2 in Burkitt' s lymphoma cell lines: Induction by latent Epstein-Barr virus genes. Blood 1992;80:459-469.
10. Chao HJ, Wang L, Wang JX, et al. Role of tumor supressor gene P53 and its antagonist oncogene mdm2 in pathogenesis of acute leukemia. J Exp Hematol (in Chinese) 1996;4:358-366.
11. Algar EM, Khromykh T, Smith SI, et al. WT1 antisense oligonueleotide inhibits proliferaton and induces apoptosis in myeloid leukemia cell lines. Oncogene 1996;12:1003-1014.