The "failure" of clinical trials in sepsis

Current Opinion in Critical Care

Volumn 5, Issue 5, 1999, Pages 339-340

  Cohen, Jonathan ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0040032792     PISSN: 10705295     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075198-199910000-00001     Document Type: Review

References (12)

1. Lynn WA, Cohen J: Adjunctive therapy for septic shock: a review of experimental approaches. Clin Infect Dis 1995, 20:143-158.
2. Abraham E, Anzueto A, Gutierrez G, Tessler S, San Pedro G, Wunderink R, Dal Nogare A, Nasraway S, Berman S, Cooney R, Levy H, Baughman RP, Rumbak M, Light RB, Poole L, Allred R, Constant J, Pennington JE, Porter S, NORASEPT II Study group: Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. Lancet 1998, 351:929-933.
3. Cohen J, Carlet J, INTERSEPT Study Group: INTERSEPT: An international multicenter placebo-controlled trial of monoclonal antibody to human TNF-α in patients with sepsis. Crit Care Med 1996, 24:1431-1440.
4. Fisher CJ Jr, Agosti JM, Opal SM, Lowry SF, Balk RA, Sadoff JC, Abraham E, Schein RM, Benjamin E: Soluble TNF Receptor Sepsis Study Group: treatment of septic shock with the tumor necrosis factor receptor: Fc fusion protein. N Engl J Med 1996, 334:1697-1702.
5. Ulevitch RJ, Tobias PS: Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol 1995, 13:437-457.
6. Yang R-B, Mark MR, Gray A, Huang A, Xie MH, Zhang M, Goddard A, Wood WI, Gurney AL, Godowski PJ: Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 1998, 395:284-288.
7. Baeuerle PA: IkB-NF-kB structures: at the interface of inflammation control. Cell 1998, 95:729-731.
8. Kilbourn RG, Szabò C, Traber DL: Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: lessons from experimental and clinical studies. Shock 1997, 7:235-246.
9. Pittet D, Li N, Woolson RF, Wenzel RP: Microbiological factors influencing the outcome of nosocomial bloodstream infections: a 6-year validated, population-based model. Clin Infect Dis 1997, 24:1068-1078.
10. de Werra I, Jaccard C, Corradin SB, Chiolero R, Yersin B, Gallati H, Assicot M, Bohuon C, Baumgartner J-D, Glauser M-P, Heumann D: Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations: comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia. Crit Care Med 1997, 25:607-613.
11. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung C, Sibbald WJ: Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 1995, 23:1638-1652.
12. Vincent J-L: Sepsis and septic shock: update on definitions. In Sepsis: Current Perspectives in Pathophysiology and Therapy. Edited by Reinhart K, Eyrich K, Sprung C. Berlin: Springer-Verlag; 1994:3-15.