Chimerism of murine fetal bone marrow by maternal cells occurs in late gestation and persists into adulthood

Laboratory Investigation

Volumn 83, Issue 5, 2003, Pages 673-681

  Marleau, Annette M ^a,b,c   Greenwood, Janice D ^a   Wei, Qingxia ^a   Singh, Bhagirath ^b   Croy, B Anne ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b ROBARTS RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLASTOCYST; BONE MARROW; CELL STRUCTURE; CELL TRANSFER; CHIMERA; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; FEMALE; FETUS; HISTOCHEMISTRY; MOUSE; NONHUMAN; PLACENTAL TRANSFER; PREGNANCY; PRIORITY JOURNAL; TRANSGENE;

EID: 0038814063     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.LAB.0000067500.85003.32     Document Type: Article

References (41)

1. Arvola M, Gustaffon E, Svensson L, Jansson L, Holmdahl R, Heyman B, Okabe M, and Mattson R (2000). Immunoglobulin-secreting cells of maternal origin can be detected in B cell-deficient mice. Biol Reprod 63:1817-1824.
2. Barnes R and Holliday J (1970). The morphological identity of maternal cells in newborn mice. Blood 36:480-490.
3. Bauer M, Orescovic I, Schoell WM, Bianchi DW, and Pertl B (2001). Detection of maternal DNA in umbilical cord plasma by fluorescent PCR amplification of short tandem repeat sequences. Ann NY Acad Sci 945:161-163.
4. Briz M, Regidor C, Monteagudo D, Somolinos N, Garaulet C, Fores R, Posada M, and Fernandez MN (1998). Detection of maternal DNA in umbilical cord blood by polymerase chain reaction amplification of minisatellite sequences. Bone Marrow Transplant 21:1097-1099.
5. Claas FH, Gijbels Y, van der Velden-de Munck J, and van Rood JJ (1998). Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life. Science 241:1815-1817.
6. Collins GD, Chrest FJ, and Adler WH (1980). Maternal cell traffic in allogeneic embryos. J Reprod Immunol 2:163-172.
7. Conley ME, Nowell PC, Henle G, and Douglas SD (1984). XX T cells and XY B cells in two patients with severe combined immune deficiency. Clin Immunol Immunopathol 31:87-95.
8. Croy BA and Chapeau C (1990). Evaluation of the pregnancy immunotrophism hypothesis by assessment of the reproductive performance of young adult mice of genotype scid/scid.bg/bg. J Reprod Fertil 88:231-239.
9. Delassus S and Cumano A (1996). Circulation of hematopoietic progenitors in the mouse embryo. Immunity 4:97-106.
10. Desai RG and Creger WP (1963). Maternal passage of leukocytes and platelets in man. Blood 21:665-673.
11. Dodds RA, Connor JR, Drake F, Field J, and Gowen M (1998). Cathepsin K mRNA detection is restricted to osteoclasts during fetal mouse development. J Bone Miner Res 13:673-682.
12. El-Alfi OS and Hathout H (1969). Maternal transfusion: Immunologic and cytogenetic evidence. Am J Obstet Gynecol 103:599-600.
13. Evans PC, Lambert N, Maloney S, Furst DE, Moore JM, and Nelson JL (1999). Long-term fetal microchimerism in peripheral blood mononuclear cell subsets in healthy women and women with scleroderma. Blood 93:2033-2037.
14. Flomenberg N, Dupont B, O'Reilly RJ, Hayward A, and Pollack MS (1983). The use of T cell culture techniques to establish the presence of an intrauterine-derived maternal T cell graft in a patient with severe combined immunodeficiency (SCID). Transplantation 36:733-735.
15. Friedrich G and Soriano P (1999). Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice. Genes Dev 5:1513-1523.
16. Greenwood JD and Croy BA (1993). A study on the engraftment and trafficking of bovine peripheral blood leukocytes in severe combined immunodeficient mice. Vet Immunol Immunopathol 38:21-44.
17. Greenwood JD, Minhas K, Di Santo JP, Makita M, Kiso Y, and Croy BA (2000). Ultrastructural studies of implantation sites from mice deficient in uterine natural killer cells. Placenta 2:693-702.
18. Hall JM, Lingenfelter P, Adams SL, Lasser D, Hansen JA, and Bean MA (1995). Detection of maternal cells in human umbilical cord blood using fluorescence in situ hybridization. Blood 86:2829-2832.
19. Hogan B, Constantini F, and Lacy E (1986). Recovery, culture, and transfer of embryos. In: Manipulating the mouse embryo. New York: Cold Spring Harbor Laboratory, 89-149.
20. Holzgreve W, Ghezzi F, Di Naro E, Ganshirt D, Maymon E, and Hahn S (1998). Disturbed feto-maternal cell traffic in preeclampsia. Obstet Gynecol 91:669-672.
21. Hunziker RD, Gambel P, and Wegmann TG (1984). Placenta as a selective barrier to cellular traffic. J Immunol 133:667-671.
22. Kaufmann MH (1992). Postimplantation period. In: Atlas of mouse development. New York: Academic Press, 17-337.
23. Ladel CH, Puschner H, Kaufmann SH, and Bamberger U (1992). Human peripheral blood leukocytes transplanted on CB17 scid-scid mice are transferred to their offspring. Eur J Immunol 22:1735-1740.
24. Le Deist F, Raffoux C, Griscelli C, and Fischer A (1987). Graft vs graft reaction resulting in the elimination of maternal cells in a SCID patient with maternofetal GVHd after an HLA identical bone marrow transplantation. J Immunol 138:423-427.
25. Lo YM, Lo ES, Watson N, Noakes L, Sargent IL, Thilaganathan B, and Wainscoat JS (1996). Two-way cell traffic between mother and fetus: Biologic and clinical implications. Blood 88:4390-4395.
26. Maloney S, Smith A, Furst DE, Myerson D, Rupert K, Evans PC, and Nelson JL (1999). Microchimerism of maternal origin persists into adult life. J Clin Invest 104:41-47.
27. Nelson JL, Furst DE, Maloney S, Gooley T, Evans PC, Smith A, Bean MA, Ober C, and Bianchi DW (1998). Microchimerism and HLA-compatible relationships of pregnancy in scleroderma. Lancet 351:559-562.
28. Petit T, Dommergues M, Socie G, Dumez Y, Gluckman E, and Brison O (1997). Detection of maternal cells in human fetal blood during the third trimester of pregnancy using allelespecific PCR amplification. Br J Haematol 98:767-771.
29. Petit T, Gluckman E, Carosella E, Brossard Y, Brison O, and Socie G (1995). A highly sensitive polymerase chain reaction method reveals the ubiquitous presence of maternal cells in human umbilical cord blood. Exp Hematol 23:1601-1605.
30. Piotrowski P and Croy BA (1996). Maternal cells are widely distributed in murine fetuses in utero. Biol Reprod 54:1103-1110.
31. Pollack SM, Kirkpatrick D, Kapoor N, Dupont B, and O'Reilly RJ (1982). Identification by HLA typing of intrauterine-derived maternal T cells in four patients with severe combined immunodeficiency. N Eng J Med 307:662-666.
32. Reed AM, Picornell YJ, Harwood A, and Kredich DW (2000). Chimerism in children with juvenile dermatomyositis. Lancet 356:2156-2157.
33. Scaradavou A, Carrier C, Mollen N, Stevens C, and Rubinstein P (1996). Detection of maternal DNA in placental/umbilical cord blood by locus-specific amplification of the noninherited maternal HLA gene. Blood 88:1494-1500.
34. Shimamura M, Ohta S, Suzuki R, and Yamazaki K (1994). Transmission of maternal blood cells to the fetus during pregnancy: Detection in mouse neonatal spleen by immunofluorescence flow cytometry and polymerase chain reaction. Blood 83:926-930.
35. Socie G, Gluckman E, Carosella E, Brossard Y, Lafon C, and Brison O (1994). Search for maternal cells in human umbilical cord blood by polymerase chain reaction amplification of two minisatellite sequences. Blood 83:340-344.
36. Suda T, Thompson LF, O'Connor RD, and Bastian JF (1984). Phenotype and function of engrafted maternal T cells in patients with severe combined immunodeficiency. J Immunol 133:2513-2517.
37. Tuffrey M, Bishun NP, and Barnes RD (1969). Porosity of the mouse placenta to maternal cells. Nature 221:1029-1030.
38. Vaidya S, Mamlok R, Daeschner CW 3rd, Williams J, Ruth J, and Goldblum RM (1991). Suppression of graft-versus-host reaction in severe combined immunodeficiency with maternal-fetal T cell engraftment. Am J Pediatr Hematol Oncol 13:172-175.
39. Zarou DM, Lichtman HC, and Hellman LM (1963). The transmission of chromium-51 tagged maternal erythrocytes from mother to fetus. Am J Obstet Gynecol 88:565-571.
40. Zhong XY, Holzgreve W, and Hahn S (2001). Circulatory fetal and maternal DNA in pregnancies at risk and those affected by preeclampsia. Ann NY Acad Sci 945:138-140.
41. Zhou L, Yoshimura Y, Huang Y-Y, Suzuki R, Yokoyama M, Okabe M, and Shimamura M (2000). Two independent pathways of maternal cell transmission to offspring: Through placenta during pregnancy and by breast-feeding after birth. Immunology 101:570-581.