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Volumn 19, Issue 2, 2003, Pages 118-127

Mechanisms of drug resistance in cancer cells

Author keywords

Cancer cells; Drug resistance; Mechanism; Methotrexate

Indexed keywords

ABC TRANSPORTER; ANTINEOPLASTIC AGENT; CELL PROTEIN; CYTOCHROME P450; GLUTATHIONE; GLYCOPROTEIN P; METHIONINE ADENOSYLTRANSFERASE; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN; POLYGLUTAMIC ACID; PROTEIN BCL XL; PROTEIN P53; RETINOBLASTOMA PROTEIN; SODIUM CHANNEL PROTEIN; UNCLASSIFIED DRUG;

EID: 0038799815     PISSN: 1682024X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (3)

References (76)
  • 1
    • 84914454996 scopus 로고
    • Inhibition of dihydrofolic reductase by aminopterin and amethopterin
    • Osborn MJ, Freeman M & Huennekens FM. Inhibition of dihydrofolic reductase by aminopterin and amethopterin. Proc Soc Exp Biol Med 1958;97:429.
    • (1958) Proc Soc Exp Biol Med , vol.97 , pp. 429
    • Osborn, M.J.1    Freeman, M.2    Huennekens, F.M.3
  • 2
    • 0015246379 scopus 로고
    • Thymidylate synthetase and its relationship to dihydrofolate reductase
    • Dunlap RB, Harding NG & Huennekens FM. Thymidylate synthetase and its relationship to dihydrofolate reductase. Ann NY Acad Sci 1971;186:153-165.
    • (1971) Ann NY Acad Sci , vol.186 , pp. 153-165
    • Dunlap, R.B.1    Harding, N.G.2    Huennekens, F.M.3
  • 4
    • 0028887425 scopus 로고
    • Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake
    • Williams FM & Flintoff WF. Isolation of a human cDNA that complements a mutant hamster cell defective in methotrexate uptake. J Biol Chem 1995;270:2987-92.
    • (1995) J Biol Chem , vol.270 , pp. 2987-2992
    • Williams, F.M.1    Flintoff, W.F.2
  • 5
    • 0029147794 scopus 로고
    • Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells
    • Moscow JA, Gong M, He R, Sgagias MK, Dixon KH, Anzick SL et al. Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells. Cancer Res 1995;55:3790-4.
    • (1995) Cancer Res , vol.55 , pp. 3790-3794
    • Moscow, J.A.1    Gong, M.2    He, R.3    Sgagias, M.K.4    Dixon, K.H.5    Anzick, S.L.6
  • 6
    • 0029084385 scopus 로고
    • Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells
    • Wong SC, Proefke SA, Bhushan A & Matherly LH. Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells. J Biol Chem 1995;270:17468-75.
    • (1995) J Biol Chem , vol.270 , pp. 17468-17475
    • Wong, S.C.1    Proefke, S.A.2    Bhushan, A.3    Matherly, L.H.4
  • 7
    • 0023879275 scopus 로고
    • Cytotoxicity, uptake, polyglutamate formation and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice
    • Kuehl M, Brixner DI, Broom AD, Avery TL & Blakley RL. Cytotoxicity, uptake, polyglutamate formation and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice. Cancer Res 1988;48:1481-1488.
    • (1988) Cancer Res , vol.48 , pp. 1481-1488
    • Kuehl, M.1    Brixner, D.I.2    Broom, A.D.3    Avery, T.L.4    Blakley, R.L.5
  • 8
    • 4244033996 scopus 로고
    • A noval mechanism of resistance to methotrexate in human breast cancer cells: Lack of methotrexate polyglutamate formation
    • Cowan KH & Jolivet J. A noval mechanism of resistance to methotrexate in human breast cancer cells: lack of methotrexate polyglutamate formation. Clin Res 1983;31:508a.
    • (1983) Clin Res , vol.31
    • Cowan, K.H.1    Jolivet, J.2
  • 9
    • 0023935785 scopus 로고
    • Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high dose treatment with this drug
    • Pizzorno G, Mini E, Coronnello M, McGuire JJ, Moroson BA, Cashmore AR et al. Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high dose treatment with this drug. Cancer Res 1988;48:2149-55.
    • (1988) Cancer Res , vol.48 , pp. 2149-2155
    • Pizzorno, G.1    Mini, E.2    Coronnello, M.3    McGuire, J.J.4    Moroson, B.A.5    Cashmore, A.R.6
  • 11
    • 0027222801 scopus 로고
    • Acquisition of resistance to antifolates caused by enhanced gamma-glutamyl hydrolase activity
    • Rhee MS, Wang Y, Nair MG & Galivan J. Acquisition of resistance to antifolates caused by enhanced gamma-glutamyl hydrolase activity. Cancer Res 1993;53:2227-30.
    • (1993) Cancer Res , vol.53 , pp. 2227-2230
    • Rhee, M.S.1    Wang, Y.2    Nair, M.G.3    Galivan, J.4
  • 12
    • 0026651775 scopus 로고
    • Metabolic turnover of methotrexate polyglutamates in lysosomes derived from S180 cells. Definition of a two-step process limited by mediated lysosomal permeation of polyglutamates and activating reduced sulfhydryl compounds
    • Barrueco JR, O'Leary DF & Sirotnak FM. Metabolic turnover of methotrexate polyglutamates in lysosomes derived from S180 cells. Definition of a two-step process limited by mediated lysosomal permeation of polyglutamates and activating reduced sulfhydryl compounds. J Biol Chem 1992;267:15356-61.
    • (1992) J Biol Chem , vol.267 , pp. 15356-15361
    • Barrueco, J.R.1    O'Leary, D.F.2    Sirotnak, F.M.3
  • 15
    • 0021797892 scopus 로고
    • Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines
    • Riordan JR, Deuchars K, Kartner N, Alon N, Trent J & Ling V. Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature 1985;316:817-9.
    • (1985) Nature , vol.316 , pp. 817-819
    • Riordan, J.R.1    Deuchars, K.2    Kartner, N.3    Alon, N.4    Trent, J.5    Ling, V.6
  • 16
    • 0024313346 scopus 로고
    • Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells
    • Keizer HG, Schuurhuis GJ, Broxterman HJ, Lankelma J, Schoonen WG, Van Rijn J et al. Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells. Cancer Res 1989;49:2988-93.
    • (1989) Cancer Res , vol.49 , pp. 2988-2993
    • Keizer, H.G.1    Schuurhuis, G.J.2    Broxterman, H.J.3    Lankelma, J.4    Schoonen, W.G.5    Van Rijn, J.6
  • 17
    • 0021916585 scopus 로고
    • Detection of P-glycoprotein in ovarian cancer: A molecular marker associated with multidrug resistance
    • Bell DR, Gerlach JH, Kartner N, Buick RN & Ling V. Detection of P-glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance. J Clin Oncol 1985;3:311-5.
    • (1985) J Clin Oncol , vol.3 , pp. 311-315
    • Bell, D.R.1    Gerlach, J.H.2    Kartner, N.3    Buick, R.N.4    Ling, V.5
  • 18
    • 0022589150 scopus 로고
    • Cross resistance of pleiotropically drug resistant P338 leukemia cells to the lipophilic antifolates trimetrexate and BW 301U
    • Klohs WD, Steinkampf RW, Besserer JA & Fry DW Cross resistance of pleiotropically drug resistant P338 leukemia cells to the lipophilic antifolates trimetrexate and BW 301U. Cancer Lett 1986;31:253-60.
    • (1986) Cancer Lett , vol.31 , pp. 253-260
    • Klohs, W.D.1    Steinkampf, R.W.2    Besserer, J.A.3    Fry, D.W.4
  • 19
    • 13344278064 scopus 로고    scopus 로고
    • Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer
    • Nooter K, Bosman FT, Burger H, Van-Wingerden KE, Flens MJ, Scheper RJ et al. Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer. Ann Oncol 1996;7:75-81.
    • (1996) Ann Oncol , vol.7 , pp. 75-81
    • Nooter, K.1    Bosman, F.T.2    Burger, H.3    Van-Wingerden, K.E.4    Flens, M.J.5    Scheper, R.J.6
  • 20
    • 0033053573 scopus 로고    scopus 로고
    • Combinations of P-glycoprotein blockers, verapamil, PSC833 and cremophor act differently on the multidrug resistance associated protein (MRP) and on P-glycoprotein (Pgp)
    • Aszalos A, Thompson K, Yin JJ & Ross DD. Combinations of P-glycoprotein blockers, verapamil, PSC833 and cremophor act differently on the multidrug resistance associated protein (MRP) and on P-glycoprotein (Pgp). Anticancer Res 1999;19:1053-64.
    • (1999) Anticancer Res , vol.19 , pp. 1053-1064
    • Aszalos, A.1    Thompson, K.2    Yin, J.J.3    Ross, D.D.4
  • 21
    • 0018263636 scopus 로고
    • Gene amplification and drug resistance in cultured murine cells
    • Schimke RT, Kaufman RJ, Alt FW & Kellems RF. Gene amplification and drug resistance in cultured murine cells. Science 1978;202:1051-5.
    • (1978) Science , vol.202 , pp. 1051-1055
    • Schimke, R.T.1    Kaufman, R.J.2    Alt, F.W.3    Kellems, R.F.4
  • 22
    • 0019124093 scopus 로고
    • Gene amplification and drug resistance
    • Schimke RT. Gene amplification and drug resistance. Sci Am 1980;243:60-9.
    • (1980) Sci Am , vol.243 , pp. 60-69
    • Schimke, R.T.1
  • 23
    • 0020479046 scopus 로고
    • On the chromatin structure of the amplified, transcriptionally active gene for dihydrofolate reductase in mouse cells
    • Barsoum J, Levinger L & Varshavsky A. On the chromatin structure of the amplified, transcriptionally active gene for dihydrofolate reductase in mouse cells. J Biol Chem 1982;257:5274-82.
    • (1982) J Biol Chem , vol.257 , pp. 5274-5282
    • Barsoum, J.1    Levinger, L.2    Varshavsky, A.3
  • 24
    • 0020955189 scopus 로고
    • Gene amplification in methotrexate-resistant mouse cells. V. Intact amplified units can be transferred to and amplified in methotrexate sensitive mouse L cells
    • Bostock C. & Clark EM. Gene amplification in methotrexate-resistant mouse cells. V. Intact amplified units can be transferred to and amplified in methotrexate sensitive mouse L cells. Chromosoma 1983;88:31-41.
    • (1983) Chromosoma , vol.88 , pp. 31-41
    • Bostock, C.1    Clark, E.M.2
  • 25
    • 0020604325 scopus 로고
    • Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment mouse 3T6 cells with hydroxyurea
    • Brown PC, Tlsty TD & Schimke, RT. Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment mouse 3T6 cells with hydroxyurea. Mol Cell Biol 1983;3:1097-107.
    • (1983) Mol Cell Biol , vol.3 , pp. 1097-1107
    • Brown, P.C.1    Tlsty, T.D.2    Schimke, R.T.3
  • 26
    • 0020355516 scopus 로고
    • Dihydrofolate reductase gene amplification and possible rearrangement in estrogen-responsive methotrexate-resistant human breast cancer cells
    • Cowan KH, Goldsmith ME, Levine RM, Aitken SC, Douglass E, Clendeninn N et al. Dihydrofolate reductase gene amplification and possible rearrangement in estrogen-responsive methotrexate-resistant human breast cancer cells. J Biol Chem 1982;257:15079-15086.
    • (1982) J Biol Chem , vol.257 , pp. 15079-15086
    • Cowan, K.H.1    Goldsmith, M.E.2    Levine, R.M.3    Aitken, S.C.4    Douglass, E.5    Clendeninn, N.6
  • 27
    • 0020318162 scopus 로고
    • Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells
    • Crouse GF, Simonsen CC, McEwan RM & Schimke RT. Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells. J Biol Chem 1982;257:7887-7897.
    • (1982) J Biol Chem , vol.257 , pp. 7887-7897
    • Crouse, G.F.1    Simonsen, C.C.2    McEwan, R.M.3    Schimke, R.T.4
  • 28
    • 0020577047 scopus 로고
    • Establishment of dihydrofolate reductase-increased human cell lines and relationship between dihydrofolate reductase levels and gene copy
    • Domin BA, Grill SP & Cheng Y. Establishment of dihydrofolate reductase-increased human cell lines and relationship between dihydrofolate reductase levels and gene copy. Cancer Res 1983;43:2155-2158.
    • (1983) Cancer Res , vol.43 , pp. 2155-2158
    • Domin, B.A.1    Grill, S.P.2    Cheng, Y.3
  • 29
    • 0020060362 scopus 로고
    • Overproduction of dihydrofolate reductase and gene amplification in methotrexate-resistant Chinese hamster ovary cells
    • Flintoff WF, Weber MK, Nagainis CR, Essani AK, Robertson D & Salser W. Overproduction of dihydrofolate reductase and gene amplification in methotrexate-resistant Chinese hamster ovary cells. Mol Cell Biol 1982;2:275-285.
    • (1982) Mol Cell Biol , vol.2 , pp. 275-285
    • Flintoff, W.F.1    Weber, M.K.2    Nagainis, C.R.3    Essani, A.K.4    Robertson, D.5    Salser, W.6
  • 30
    • 0021356228 scopus 로고
    • Moderate level gene amplification in methotrexate-resistant Chinese hamster ovary cells is accompanied by chromosomal translocations at or near the site of the amplified DHFR gene
    • Flintoff WF, Livingston E, Duff C & Worton RG. Moderate level gene amplification in methotrexate-resistant Chinese hamster ovary cells is accompanied by chromosomal translocations at or near the site of the amplified DHFR gene. Mol Cell Biol 1984;4:69-76.
    • (1984) Mol Cell Biol , vol.4 , pp. 69-76
    • Flintoff, W.F.1    Livingston, E.2    Duff, C.3    Worton, R.G.4
  • 31
    • 0020318924 scopus 로고
    • Gene amplification accompanies low level increases in the activity of dihydrofolate reductase in antifolate-resistant Chinese hamster lung cells containing abnormally banding chromosomes
    • Lewis JA, Biedler JL & Melera PW. Gene amplification accompanies low level increases in the activity of dihydrofolate reductase in antifolate-resistant Chinese hamster lung cells containing abnormally banding chromosomes. J Cell Biol 1982;94:418-424.
    • (1982) J Cell Biol , vol.94 , pp. 418-424
    • Lewis, J.A.1    Biedler, J.L.2    Melera, P.W.3
  • 32
    • 0020511793 scopus 로고
    • Increased levels of dihydrofolate reductase mRNA can be measured in normal, growth-stimulated mouse fibroblasts
    • Mullner E, Hofbauer R & Wintersberger E. Increased levels of dihydrofolate reductase mRNA can be measured in normal, growth-stimulated mouse fibroblasts. Biochem Biophys Acta 1983;740:436-440.
    • (1983) Biochem Biophys Acta , vol.740 , pp. 436-440
    • Mullner, E.1    Hofbauer, R.2    Wintersberger, E.3
  • 33
    • 0021332062 scopus 로고
    • Cytologic evidence for gene amplification in methotrexate-resistant cells obtained from a patient with ovarian adenocarcinoma
    • Trent JM, Buick RN, Olson S, Horns RC Jr. & Schimke RT. Cytologic evidence for gene amplification in methotrexate-resistant cells obtained from a patient with ovarian adenocarcinoma. J Clin Oncol 1984;2:8-15.
    • (1984) J Clin Oncol , vol.2 , pp. 8-15
    • Trent, J.M.1    Buick, R.N.2    Olson, S.3    Horns R.C., Jr.4    Schimke, R.T.5
  • 34
    • 0011815638 scopus 로고
    • Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes
    • Kaufman RJ, Brown PC & Schimke RT. Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes. Proc Natl Acad Sci USA 1979;76:5659-5673.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 5659-5673
    • Kaufman, R.J.1    Brown, P.C.2    Schimke, R.T.3
  • 35
    • 0025361947 scopus 로고
    • Dihydrofolate reductase as a therapeutic target
    • Schweitzer BI, Dicker AP & Bertino JR. Dihydrofolate reductase as a therapeutic target. FASEB J 1990;4:2441-2452.
    • (1990) FASEB J , vol.4 , pp. 2441-2452
    • Schweitzer, B.I.1    Dicker, A.P.2    Bertino, J.R.3
  • 36
    • 0026209608 scopus 로고
    • Acquired versus intrinsic resistance to methotrexate: Diversity of the drug-resistant phenotype in mammalian cells
    • Melera PW. Acquired versus intrinsic resistance to methotrexate: diversity of the drug-resistant phenotype in mammalian cells. Semin Cancer Biol 1991;2:245-255.
    • (1991) Semin Cancer Biol , vol.2 , pp. 245-255
    • Melera, P.W.1
  • 38
    • 0015948351 scopus 로고
    • Isolation and characterization of the multiple forms of dihydrofolate reductase from methotrexate-resistant hamster cells
    • Hanggi UJ & Littlefield JW. Isolation and characterization of the multiple forms of dihydrofolate reductase from methotrexate-resistant hamster cells. J Biol Chem 1974;249:1390-1397.
    • (1974) J Biol Chem , vol.249 , pp. 1390-1397
    • Hanggi, U.J.1    Littlefield, J.W.2
  • 39
    • 0019174166 scopus 로고
    • Methotrexate-resistant Chinese hamster ovary cells contain a dihydrofolate reductase with an altered affinity for methotrexate
    • Flintoff WF & Essani K. Methotrexate-resistant Chinese hamster ovary cells contain a dihydrofolate reductase with an altered affinity for methotrexate. Biochemistry 1980;19:4321-4327.
    • (1980) Biochemistry , vol.19 , pp. 4321-4327
    • Flintoff, W.F.1    Essani, K.2
  • 40
    • 0015364903 scopus 로고
    • Two different species of dihydrofolate reductase in mammalian cells differently resistant to amethropterin and methasquin
    • Albrecht AM, Biedler JL & Hutchison DJ. Two different species of dihydrofolate reductase in mammalian cells differently resistant to amethropterin and methasquin. Cancer Res 1972;32:1539-1546.
    • (1972) Cancer Res , vol.32 , pp. 1539-1546
    • Albrecht, A.M.1    Biedler, J.L.2    Hutchison, D.J.3
  • 41
    • 0020571577 scopus 로고
    • Overproduction of two antigenically distinct forms of dihydrofolate reductase in a highly methotrexate-resistant mouse leukemia cell line
    • Dedhar S & Goldie JF. Overproduction of two antigenically distinct forms of dihydrofolate reductase in a highly methotrexate-resistant mouse leukemia cell line. Cancer Res 1983;43:4863.
    • (1983) Cancer Res , vol.43 , pp. 4863
    • Dedhar, S.1    Goldie, J.F.2
  • 42
    • 0021339923 scopus 로고
    • Multiple forms of L1210 dihydrofolate reductase differing in affinity for methotrexate
    • Duffy TH, Beckman SB & Huennekens FM. Multiple forms of L1210 dihydrofolate reductase differing in affinity for methotrexate. Biochem Biophys Res Commun 1984;119:352-358.
    • (1984) Biochem Biophys Res Commun , vol.119 , pp. 352-358
    • Duffy, T.H.1    Beckman, S.B.2    Huennekens, F.M.3
  • 43
    • 0019817704 scopus 로고
    • Properties of an altered dihydrofolate reductase encoded by amplified genes in cultured mouse fibroblasts
    • Haber DA, Beverley SM, Kiely ML & Schinmke RT. Properties of an altered dihydrofolate reductase encoded by amplified genes in cultured mouse fibroblasts. J Biol Chem 1981;256:9501-9510.
    • (1981) J Biol Chem , vol.256 , pp. 9501-9510
    • Haber, D.A.1    Beverley, S.M.2    Kiely, M.L.3    Schinmke, R.T.4
  • 44
    • 0019130350 scopus 로고
    • Antifolate resistant Chinese hamster cells: Evidence for dihydrofolate reductase gene amplification among independently derived sublines overproducing different dihydrofolate reductases
    • Melera PW, Lewis JA, Biedler JL & Hession C. Antifolate resistant Chinese hamster cells: evidence for dihydrofolate reductase gene amplification among independently derived sublines overproducing different dihydrofolate reductases. J Biol Chem 1980;255:7024-7028.
    • (1980) J Biol Chem , vol.255 , pp. 7024-7028
    • Melera, P.W.1    Lewis, J.A.2    Biedler, J.L.3    Hession, C.4
  • 45
    • 0021972928 scopus 로고
    • A new form of dihydrofolate reductase in cancer cells
    • Iqbal MP & Rothenberg SP. A new form of dihydrofolate reductase in cancer cells. J Pak Med Assoc 1985;35:237-242.
    • (1985) J Pak Med Assoc , vol.35 , pp. 237-242
    • Iqbal, M.P.1    Rothenberg, S.P.2
  • 46
  • 47
    • 0026047236 scopus 로고
    • Evidence for kinetic and immunologic heterogeneity of dihydrofolate reductase in L1210 leukemia cells
    • Iqbal MP, Rothenberg SP & da Costa M. Evidence for kinetic and immunologic heterogeneity of dihydrofolate reductase in L1210 leukemia cells. Biochem Med Metab Biol 1991;46:196-207.
    • (1991) Biochem Med Metab Biol , vol.46 , pp. 196-207
    • Iqbal, M.P.1    Rothenberg, S.P.2    Da Costa, M.3
  • 48
    • 0019453058 scopus 로고
    • Role of glutathione in the metabolism dependent toxicity and chemotherapy of cyclophosphamide
    • Gurtoo HL, Hipkens JH & Sharma CD. Role of glutathione in the metabolism dependent toxicity and chemotherapy of cyclophosphamide. Cancer Res 1981;41:3584-3591.
    • (1981) Cancer Res , vol.41 , pp. 3584-3591
    • Gurtoo, H.L.1    Hipkens, J.H.2    Sharma, C.D.3
  • 50
    • 0020659245 scopus 로고
    • Dechlorination of L-phenylalanine mustard by sensitive and resistant tumor cells and its relationship to intracellular glutathione content
    • Suzukake K, Vistica BP & Vistica DT. Dechlorination of L-phenylalanine mustard by sensitive and resistant tumor cells and its relationship to intracellular glutathione content. Biochem Pharmacol 1983;32: 165-167.
    • (1983) Biochem Pharmacol , vol.32 , pp. 165-167
    • Suzukake, K.1    Vistica, B.P.2    Vistica, D.T.3
  • 51
    • 0021127473 scopus 로고
    • Glutathione metabolism as a determinant of therapeutic efficacy: A review
    • Arrick BA & Nathan CF. Glutathione metabolism as a determinant of therapeutic efficacy: a review. Cancer Res 1984;44:4224-4232.
    • (1984) Cancer Res , vol.44 , pp. 4224-4232
    • Arrick, B.A.1    Nathan, C.F.2
  • 52
    • 0020537304 scopus 로고
    • Selective modification of glutathione metabolism
    • Meister A. Selective modification of glutathione metabolism. Science 1983;220:472-477.
    • (1983) Science , vol.220 , pp. 472-477
    • Meister, A.1
  • 53
    • 0022384738 scopus 로고
    • Differential potentiation of alkylating and platinating agent cytotoxicity in human ovarian carcinoma cells by glutathione depletion
    • Andrews PA, Murphy MP & Howell SB. Differential potentiation of alkylating and platinating agent cytotoxicity in human ovarian carcinoma cells by glutathione depletion Cancer Res 1985;45:6250-6253.
    • (1985) Cancer Res , vol.45 , pp. 6250-6253
    • Andrews, P.A.1    Murphy, M.P.2    Howell, S.B.3
  • 54
    • 0027399235 scopus 로고
    • Glutathione depletion increases the cytotoxicity of melphalan to PC-3 an androgen-insensitive prostate cancer cell line
    • Canada A, Herman L, Kidd K, Roberrson C & Trump D. Glutathione depletion increases the cytotoxicity of melphalan to PC-3 an androgen-insensitive prostate cancer cell line. Cancer Chemother Pharmacol 1993;32:73-77.
    • (1993) Cancer Chemother Pharmacol , vol.32 , pp. 73-77
    • Canada, A.1    Herman, L.2    Kidd, K.3    Roberrson, C.4    Trump, D.5
  • 55
    • 0021721547 scopus 로고
    • Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion
    • Green JA, Vistica DT, Young RC, Hamilton TC, Rogan AM & Ozols RF. Potentiation of melphalan cytotoxicity in human ovarian cancer cell lines by glutathione depletion. Cancer Res 1984;44:5427-5431.
    • (1984) Cancer Res , vol.44 , pp. 5427-5431
    • Green, J.A.1    Vistica, D.T.2    Young, R.C.3    Hamilton, T.C.4    Rogan, A.M.5    Ozols, R.F.6
  • 56
    • 0021878218 scopus 로고
    • Augmentation of adriamycin, melphalan and cisplatin cytotoxicity in drug-resistant and sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion
    • Hamilton TC, Winkler C, Louie K, Batist G, Bchrens B, Tsuruo T et al. Augmentation of adriamycin, melphalan and cisplatin cytotoxicity in drug-resistant and sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion Biochem Pharmacol 1985;34:2583-2586.
    • (1985) Biochem Pharmacol , vol.34 , pp. 2583-2586
    • Hamilton, T.C.1    Winkler, C.2    Louie, K.3    Batist, G.4    Bchrens, B.5    Tsuruo, T.6
  • 57
    • 0020086089 scopus 로고
    • Reduction in glutathione content of L-PAM-resistant L1210 cells confers drug sensitivity
    • Suzukake K, Petro BJ & Vistica DT. Reduction in glutathione content of L-PAM-resistant L1210 cells confers drug sensitivity. Biochem Pharmacol 1982;31:121-124.
    • (1982) Biochem Pharmacol , vol.31 , pp. 121-124
    • Suzukake, K.1    Petro, B.J.2    Vistica, D.T.3
  • 58
    • 0021815179 scopus 로고
    • Radiation survival parameters of antineoplastic drug sensitive and resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine
    • Louie KG, Behrens BC, Kinsella TJ, Hamilton TC, Grotzinger KR, McKoy WM et al. Radiation survival parameters of antineoplastic drug sensitive and resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine. Cancer Res 1985;45:2110-2115.
    • (1985) Cancer Res , vol.45 , pp. 2110-2115
    • Louie, K.G.1    Behrens, B.C.2    Kinsella, T.J.3    Hamilton, T.C.4    Grotzinger, K.R.5    McKoy, W.M.6
  • 59
    • 0021332334 scopus 로고
    • Reduction in cellular glutathione by buthionine sulfoximine and sensitization of murine tumor cells resistant to L-phenylalanine mustard
    • Somfai-Relle S, Suzukake K, Vistica BP & Vistiea DT. Reduction in cellular glutathione by buthionine sulfoximine and sensitization of murine tumor cells resistant to L-phenylalanine mustard. Biochem Pharmacol 1984;33:485-490.
    • (1984) Biochem Pharmacol , vol.33 , pp. 485-490
    • Somfai-Relle, S.1    Suzukake, K.2    Vistica, B.P.3    Vistiea, D.T.4
  • 60
    • 0023119841 scopus 로고
    • Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor bearing nude mice by buthionine sulfoximine depletion of glutathione
    • Ozols RF, Louie KG, Plowman J, Behrens BC, Fine RL, Dykes D et al. Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor bearing nude mice by buthionine sulfoximine depletion of glutathione. Biochem Pharmacol 1987;36:147-153.
    • (1987) Biochem Pharmacol , vol.36 , pp. 147-153
    • Ozols, R.F.1    Louie, K.G.2    Plowman, J.3    Behrens, B.C.4    Fine, R.L.5    Dykes, D.6
  • 61
    • 0024334410 scopus 로고
    • The effect of ifosfamide and its metabolites on intracellular glutathione levels in vitro and in vivo
    • Lind MJ, McGowan AT, Hadfield JA, Thatcher N, Crowther D & Fox BW. The effect of ifosfamide and its metabolites on intracellular glutathione levels in vitro and in vivo. Biochem Pharmacol 1989;38:1835-1840
    • (1989) Biochem Pharmacol , vol.38 , pp. 1835-1840
    • Lind, M.J.1    McGowan, A.T.2    Hadfield, J.A.3    Thatcher, N.4    Crowther, D.5    Fox, B.W.6
  • 62
    • 0028094936 scopus 로고
    • Ifosfamide induced depletion of glutathione in human peripheral blood lymphocytes and protection by mesna
    • Meier T, Allenbacher A, Mueller F, Multhoff G, Botzler C, Weisnet M et al. Ifosfamide induced depletion of glutathione in human peripheral blood lymphocytes and protection by mesna. Anticancer Drugs 1994;5:403-409.
    • (1994) Anticancer Drugs , vol.5 , pp. 403-409
    • Meier, T.1    Allenbacher, A.2    Mueller, F.3    Multhoff, G.4    Botzler, C.5    Weisnet, M.6
  • 63
    • 0031032439 scopus 로고    scopus 로고
    • Effect of ifosfamide on intracellular glutathione levels in peripheral blood lymphocytes and its correlation with therapeutic response in patients with advanced ovarian cancer
    • Malik IA, Mehboobali N & Iqbal MP. Effect of ifosfamide on intracellular glutathione levels in peripheral blood lymphocytes and its correlation with therapeutic response in patients with advanced ovarian cancer. Cancer Chemother Pharmacol 1997;39:561-565.
    • (1997) Cancer Chemother Pharmacol , vol.39 , pp. 561-565
    • Malik, I.A.1    Mehboobali, N.2    Iqbal, M.P.3
  • 65
    • 0028025563 scopus 로고
    • Apoptosis in cancer therapy: Crossing the threshold
    • Fisher DE. Apoptosis in cancer therapy: crossing the threshold. Cell 1994;78:539-42.
    • (1994) Cell , vol.78 , pp. 539-542
    • Fisher, D.E.1
  • 66
    • 0028986856 scopus 로고
    • Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells
    • Spinella MJ, Brigle KE, Sierra EE & Goldman ID. Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells. J Biol Chem 1995;270:7842-9.
    • (1995) J Biol Chem , vol.270 , pp. 7842-7849
    • Spinella, M.J.1    Brigle, K.E.2    Sierra, E.E.3    Goldman, I.D.4
  • 68
    • 0028231586 scopus 로고
    • Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene
    • Fujiwara T, Grimm EA, Mukhopadhyay T, Zhang WW, Owen-Schaub LB & Roth JA. Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res 1994;54:2287-2291.
    • (1994) Cancer Res , vol.54 , pp. 2287-2291
    • Fujiwara, T.1    Grimm, E.A.2    Mukhopadhyay, T.3    Zhang, W.W.4    Owen-Schaub, L.B.5    Roth, J.A.6
  • 69
    • 0028958030 scopus 로고
    • Bcl-2 prevention of apoptosis as a mechanism of drug resistance
    • Reed JC. Bcl-2 prevention of apoptosis as a mechanism of drug resistance. Hematol Oncol Clin North Am 1995;9:451-473.
    • (1995) Hematol Oncol Clin North Am , vol.9 , pp. 451-473
    • Reed, J.C.1
  • 71
    • 0035300476 scopus 로고    scopus 로고
    • Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure
    • Komatani H, Kotani H, Hara Y, Nakagawa R, Matsumoto M, Arakawa H et al. Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure. Cancer Res 2001;61:2827-2832,
    • (2001) Cancer Res , vol.61 , pp. 2827-2832
    • Komatani, H.1    Kotani, H.2    Hara, Y.3    Nakagawa, R.4    Matsumoto, M.5    Arakawa, H.6
  • 72
    • 0000776551 scopus 로고    scopus 로고
    • Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated with P-glycoprotein or MRP expression
    • Lee JS, Scala S, Matsumoto Y, Dickstein B, Robey R, Zhan Z et al. Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated with P-glycoprotein or MRP expression. J Cell Biochem 1997;65:513-526.
    • (1997) J Cell Biochem , vol.65 , pp. 513-526
    • Lee, J.S.1    Scala, S.2    Matsumoto, Y.3    Dickstein, B.4    Robey, R.5    Zhan, Z.6
  • 73
    • 0033561556 scopus 로고    scopus 로고
    • S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosyl homocysteine hydrolase a novel mechanism of drug resistance
    • Dwivedi RS, Wang LJ & Mirkin BL. S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosyl homocysteine hydrolase a novel mechanism of drug resistance. Cancer Res 1999;59:1852-1856.
    • (1999) Cancer Res , vol.59 , pp. 1852-1856
    • Dwivedi, R.S.1    Wang, L.J.2    Mirkin, B.L.3
  • 74
    • 0028871672 scopus 로고
    • Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines
    • Li W, Fan J, Hochhauser D, Banerjee D, Zielinski Z, Almasan A et al. Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines. Proc Natl Acad Sci USA 1995;92:10436-40.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10436-10440
    • Li, W.1    Fan, J.2    Hochhauser, D.3    Banerjee, D.4    Zielinski, Z.5    Almasan, A.6
  • 75
    • 0026342232 scopus 로고
    • Abnormalities of the retinoblastoma gene in the pathogenesis of acute leukemia
    • Ahuja HG, Jat PS, Foti A, Bar-Eli M. & Cline MJ. Abnormalities of the retinoblastoma gene in the pathogenesis of acute leukemia. Blood 1991;78:3259-3268.
    • (1991) Blood , vol.78 , pp. 3259-3268
    • Ahuja, H.G.1    Jat, P.S.2    Foti, A.3    Bar-Eli, M.4    Cline, M.J.5
  • 76
    • 0028352734 scopus 로고
    • Levels of retinoblastoma protein expression in newly diagnosed acute myelogenous leukemia
    • Kornblau SM, Xu HJ, Zhang W, Hu SX, Beran M, Smith TL et al. Levels of retinoblastoma protein expression in newly diagnosed acute myelogenous leukemia. Blood 1994;84:256-261.
    • (1994) Blood , vol.84 , pp. 256-261
    • Kornblau, S.M.1    Xu, H.J.2    Zhang, W.3    Hu, S.X.4    Beran, M.5    Smith, T.L.6


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