Reduction in injection pain with botulinum toxin type B further diluted using saline with preservative: A double-blind, randomized controlled trial

Journal of the American Academy of Dermatology

Volumn 48, Issue 6, 2003, Pages 875-877

  Van Laborde, S ^f   Dover, Jeffrey S ^a,b,e   Moore, Megan ^f   Stewart, Brigitte ^f   Arndt, Kenneth A ^a,b,c   Alam, Murad ^d  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

^e SkinCare Physicians of Chestnut Hill   (United States)

^f NONE

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN B; PRESERVATIVE; SODIUM CHLORIDE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DILUTION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FORMULATION; FACE; FEMALE; HUMAN; INJECTION PAIN; MALE; PAIN ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0038793676     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1067/mjd.2003.487     Document Type: Article

References (9)

1. Alam M, Dover JS, Arndt KA. Pain associated with injection of botulinum A exotoxin reconstituted using saline with and without preservative: a double-blind, randomized controlled trial. Arch Dermatol 2002;38:510-4.
2. McIellan K, Das RE, Ekong TA, Sesardic D. Therapeutic botulinum type A toxin: factors affecting potency. Toxicon 1996;34:975-85.
3. Huang W, Foster JA, Rogachefsky AS. Pharmacology of botulinum toxin. J Am Acad Dermatol 2000;43:249-59.
4. Klein AW. Dilution and storage of botulinum toxin. Dermatol Surg 1998;24:1179-80.
5. Botulinum toxin for frown lines. Med Lett. May 27, 2002; (1131):47-8.
6. Myobloc (Botulinum toxin type B) [package insert]. South San Francisco, CA: Elan Pharmaceuticals Inc; 2000.
7. Matarasso S. What's new in botulinum toxin. In: Symposium on New and Emerging Therapies, American Academy of Dermatology, 60th Annual Meeting; February 26, 2002; New Orleans, La.
8. Lowe NJ, Yamauchi PS, Lask GP, Patnaik R, Moore D. Botulinum toxins types A and B for brow furrows: preliminary experiences with type B toxin dosing. J Cosmet Laser Ther 2002;4:15-8.
9. Spencer JM, Gordon M, Goldberg DJ. Botulinum B treatment of the glabellar and frontalis regions: a dose response analysis. J Cosmet Laser Ther 2002;4:19-23.