Metabolic effects of a corticosteroid-free immunosuppressive regimen in recipients of pancreatic transplant

Transplantation

Volumn 75, Issue 12, 2003, Pages 2018-2023

  Luzi, Livio ^a   Sereni, Lucia Piceni ^a   Battezzati, Alberto ^a   Elli, Attilio ^b   Soulillou, Jean Paul ^c   Cantarovich, Diego ^c  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^c Centre Hopitalier Universitaire   (France)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; APOLIPOPROTEIN A1; AZATHIOPRINE; C PEPTIDE; CORTICOSTEROID; CYCLOSPORIN; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; INSULIN; LACTIC ACID; PREDNISONE; PYRUVIC ACID;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; FEMALE; GLUCOSE HOMEOSTASIS; GRAFT REJECTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY TRANSPLANTATION; MALE; PANCREAS TRANSPLANTATION; PRIORITY JOURNAL;

ADRENAL CORTEX HORMONES; ADULT; AZATHIOPRINE; BLOOD GLUCOSE; C-PEPTIDE; CYCLOPHOSPHAMIDE; DIABETES MELLITUS, TYPE 1; DRUG THERAPY, COMBINATION; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; KINETICS; MALE; PANCREAS TRANSPLANTATION; PREDNISONE;

EID: 0038789158     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000065177.18714.2E     Document Type: Article

References (26)

1. Sutherland DE, Gruessner RW, Gruessner AC. Pancreas transplantation for treatment of diabetes mellitus. World J Surg 2001; 25: 487-496.
2. Smets YF, van der Pijl JW, Frolich M, et al. Insulin secretion and sensitivity after simultaneous pancreas-kidney transplantation estimated by continuous infusion of glucose with model assessment. Transplantation 2000; 69: 1322-1327.
3. Robertson RP, Sutherland DE, Lanz KJ. Normoglycemia and preserved insulin secretory reserve in diabetic patients 10-18 years after pancreas transplantation. Diabetes 1999; 48: 1737-1740.
4. Luzi L. Pancreas transplantation and diabetic complications. N Engl J Med 1998; 339(2): 115-117.
5. Gross CR, Limwattananon C, Matthees B, et al. Impact of transplantation on quality of life in patients with diabetes and renal dysfunction. Transplantation. 2000; 70: 1736-1746.
6. Cantarovich D, Karam G, Giral-Classe M, et al. Randomized comparison of triple therapy and antithymocyte globulin induction treatment after simultaneous pancreas-kidney transplantation. Kidney Int 1998; 54: 1351-1356.
7. Cantarovich D, Giral-Classe M, Hourmant M, et al. Low incidence of kidney rejection after simultaneous kidney-pancreas transplantation after antithymocyte globulin induction and in the absence of corticosteroids: results of a prospective pilot study in 28 consecutive cases. Transplantation 2000; 69(7): 1505-1508.
8. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230-238.
9. Ryan EA, Lakey JR, Rajotte RV, et al. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 2001; 50(4): 710-719.
10. Luzi L, Secchi A, Facchini F, et al. Reduction of insulin resistance by combined kidney-pancreas transplantation in type 1 (insulin-dependent) diabetic patients. Diabetologia 1990; 33: 549-556.
11. Luzi L, Battezzati A, Perseghin G, et al. Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients. J Clin Invest 1994; 93: 1948-1958.
12. Luzi L, Groop LC, Perseghin G, et al. Effect of pancreas transplantation on free fatty acid metabolism in uremic IDDM patients. Diabetes 1996; 45: 354-360.
13. Battezzati A, Benedini S, Fattorini A, et al. Effect of hypoglycemia on amino acid and protein metabolism in healthy humans. Diabetes 2000; 49: 1543-1551.
14. Steele R. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann N Y Acad Sci 1959; 82: 420.
15. Martinenghi S, Secchi A, Luzi L, et al. Acute deterioration of pancreatic graft function presumably determined by steroid-induced insulin resistance: a case report. Transplantation 1993; 56: 241-244.
16. Tarantino A, Montagnino G, Ponticelli C. Corticosteroids in kidney transplant recipients. Safety issues and timing of discontinuation. Drug Saf 1995; 13: 145-156.
17. Reding R. Steroid withdrawal in liver transplantation: benefits, risks, and unanswered questions. Transplantation 2000; 70: 405-410.
18. Perseghin G, Mazzaferro V, Sereni LP, et al. Contribution of reduced insulin sensitivity and secretion to the pathogenesis of hepatogenous diabetes: effect of liver transplantation. Hepatology 2000; 31(3): 694-703.
19. Benedini S, Fiocchi R, Battezzati A, et al. Energy metabolism in diabetic and nondiabetic heart transplanted patients. Diabetes Care 2002; 25: 530-536.
20. Fernandez-Miranda C, de la Calle A, Morales JM, et al. Lipoprotein abnormalities in long-term stable liver and renal transplanted patients. A comparative study. Clin Transplant 1998; 12(2): 136-141.
21. Taghibiglou C, Carpentier A, Van Iderstine SC, et al. Mechanisms of hepatic very low density lipoprotein overproduction in insulin resistance. Evidence for enhanced lipoprotein assembly, reduced intracellular ApoB degradation, and increased microsomal triglyceride transfer protein in a fructose-fed hamster model. J Biol Chem 2000; 275(12): 8416-8425.
22. Carpentier A, Patterson BW, Uffelman KD, et al. The effect of systemic versus portal insulin delivery in pancreas transplantation on insulin action and VLDL metabolism. Diabetes 2001; 50: 1402-1413.
23. Abernethy LJ, Davidson DC, Lamont GL, et al. Intra-arterial calcium stimulation test in the investigation of hyperinsulinaemic hypoglycaemia. Arch Dis Child 1998; 78(4): 359-363.
24. Widmer P, Maibach R, Kunzi UP, et al. Diuretic-related hypokalaemia: the role of diuretics, potassium supplements, glucocorticoids and beta 2-adrenoceptor agonists. Results from the comprehensive hospital drug monitoring programme, Berne (CHDM). Eur J Clin Pharmacol 1995; 49: 31-36.
25. Cohen P, Barzilai N, Lerman A, et al. Insulin effects on glucose and potassium metabolism in vivo: evidence for selective insulin resistance in humans. J Clin Endocrinol Metab 1991; 73: 564-568.
26. Alvestrand A, Wahren J, Smith D, et al. Insulin-mediated potassium uptake is normal in uremic and healthy subjects. Am J Physiol 1984; 246 (2 Pt 1): E174-180.