Protein-energy malnutrition and involuntary weight loss: Nutritional and pharmacological strategies to enhance wound healing

Expert Opinion on Pharmacotherapy

Volumn 4, Issue 7, 2003, Pages 1121-1140

  Collins, Nancy ^a  

^a Nutrition Guidance Center   (United States)

Author keywords

Anabolism; Catabolism; Involuntary weight loss; Protein energy malnutrition; Wound healing

Indexed keywords

AMLODIPINE; ANABOLIC AGENT; ANTIDEPRESSANT AGENT; ANTIHISTAMINIC AGENT; APPETITE STIMULANT; ARGINAID; ARGINAID EXTRA; ARGININE; ASCORBIC ACID; CIPROFLOXACIN; CORTICOSTEROID; DIGOXIN; DRONABINOL; ENALAPRIL MALEATE; ESOMEPRAZOLE; FAMOTIDINE; FUROSEMIDE; GLUTAMINE; HUMAN GROWTH HORMONE; IPRATROPIUM BROMIDE; MEGESTROL ACETATE; MIRTAZAPINE; MULTIVITAMIN; NARCOTIC ANALGESIC AGENT; NUTRIFOCUS; OXANDROLONE; PERATIVE; RECOMBINANT GROWTH HORMONE; SEDATIVE AGENT; SEROSTIN; TESTOSTERONE; TRACE ELEMENT; UNCLASSIFIED DRUG; UNINDEXED DRUG; WARFARIN; ZINC;

ABDOMINAL PAIN; ACNE; ALOPECIA; APPETITE DISORDER; BLEEDING; BODY COMPOSITION; BODY WEIGHT DISORDER; CALORIC INTAKE; CATABOLISM; CLINICAL TRIAL; CLITORIS; CONFUSION; CONSTIPATION; DEEP VEIN THROMBOSIS; DEPRESSION; DIARRHEA; DISEASE EXACERBATION; DROWSINESS; DRUG DOSE REGIMEN; DRUG FATALITY; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENTIATION; DYSLIPIDEMIA; DYSPNEA; EDEMA; ELECTROLYTE DISTURBANCE; EUPHORIA; EXCITATION; FECES INCONTINENCE; FEMALE; FLUID RETENTION; GENITAL SYSTEM DISEASE; GLUCOSE INTOLERANCE; GYNECOMASTIA; HEART FAILURE; HEPATOMEGALY; HIGH RISK POPULATION; HIRSUTISM; HOT FLUSH; HUMAN; HYPERGLYCEMIA; HYPERHIDROSIS; HYPERTENSION; HYPOGONADISM; HYPOTENSION; INSOMNIA; LABORATORY DIAGNOSIS; LEAN BODY WEIGHT; LETHARGY; MALAISE; MALE; MALE TYPE ALOPECIA; MENTAL DISEASE; MICTURITION DISORDER; MOOD DISORDER; MUSCLE ATROPHY; MUSCULOSKELETAL DISEASE; MYALGIA; NAUSEA AND VOMITING; NIGHTMARE; NUTRITIONAL SUPPORT; PARANOIA; PATHOPHYSIOLOGY; PROTEIN CALORIE MALNUTRITION; PROTEIN INTAKE; RASH; REVIEW; SEDATION; SPEECH DISORDER; THROMBOPHLEBITIS; TINNITUS; VERTIGO; VISUAL DISORDER; WEIGHT REDUCTION; WOUND HEALING IMPAIRMENT; XEROSTOMIA;

EID: 0038783534     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.4.7.1121     Document Type: Review

References (61)

1. BOURAS EP, LANGE SM, SCOLAPIO JS: Rational approach to patients with unintentional weight loss. Mayo Clin. Proc. (2001) 76:923-929.
2. COLLINS N: Assessment and treatment of involuntary weight loss and protein-energy malnutrition. Adv. Skin Wound Care (2000) 13(Suppl. 1):4-10.
3. MCWHIRTER JP, PENNINGTON CR: Incidence and recognition of malnutrition in hospital. Br. Med. J. (1994) 308:945-948.
4. SULLIVAN DH, SUN S, WALLS RC: Protein-energy undernutrition among elderly hospitalized patients: a prospective study. JAMA (1999) 281:2013-2019.
5. DESANTI L: Involuntary weight loss and die nonhealing wound. Adv Skin Wound Care (2001) 11(Suppl. 1):12-20.
6. SHAVER HJ, LOPER JA, LUTES RA: Nutritional status of nursing home patients. J. Parenter. Enteral. Nutr. (1980) 4:367-370.
7. SILVER AJ, MORLEY JE, STROME LS, JONES D, VICKERS L: Nutritional status in an academic nursing home. J. Am. Geriatr. Soc. (1988) 36:487-491.
8. THOMAS DR, ZDROWSKI CD, WILSON MM et al.: Malnutrition in subacute care. Am. J. Clin. Nutr. (2002) 75:308-313.
9. LARSSON J, UNOSSON M, EK AC, NILSSON L, THORSLUND S, BJURULF P: Effect of dietary supplementation on nutritional status and clinical outcome in 501 geriatric patients in a randomized study. Clin. Nutr. (1990) 9:179-184.
10. MORLEY JE: Nutrition in the elderly. Curr. Opin. Gastroenterol. (2002) 18:240-245.
11. BROQVIST M, ARNQVIST H, DAHLSTROM U et al.: Nutritional assessment and muscle energy metabolism in severe chronic congestive heart failure - effects of long-term dietary supplementation. Eur. Heart. J. (1994) 15:1641-1650.
12. AKNER G, CEDERHOLM T: Treatment of protein-energy malnutrition in chronic malignant disorders. Am. J. Clin. Nutr. (2001) 74:6-24.
13. KEARNS PJ, THOMPSON JD, WERNER PC et al.: Nutritional and metabolic response to acute spinal-cord injury. J. Parenter. Enteral. Nutr. (1992) 16:11-15.
14. DEMLING RH, DESANTI L: Use of anticatabolic agents for burns. Curr. Opin. Crit. Care (1996) 2:482-491.
15. OTTERY F: Supportive nutritional management of the patient with pancreatic cancer. Oncology (Huntingt) (1996) 10(Suppl.):26-32.
16. COODLEY GO, LOVELESS MO, MERRILL TM: The HIV wasting syndrome: a review. J. Acquir. Immune Defic. Syndr. (1994) 7:681-694.
17. SLIVA M, SKOLNICK PR, GORBACH SL et al.: The effect of protease inhibitors on weight and body composition in HIV-infected patients. AIDS (1998) 12:1645-1651.
18. KENNEDY KL: Exploring options for involuntary weight loss and wound healing. Involuntary weight loss: definition, diagnosis, documentation. Adv. Skin Wound Care (2001) 15(Suppl. 1).
19. CHANG JI, KATCH PR, AMBROSE P: Weight loss in nursing home patients: prognostic implications. Fam. Pract. (1990) 30:671-674.
20. MURDEN RA, AINSLIE NK: Recent weight loss is related to short-term mortality in nursing homes. J. Gen. Intern. Med. (1994) 9:648-650.
21. RYAN C, BRYANT E, ELEAZER P, RHODES A, GUEST K: Unintentional weight loss in long-term care: predictor of mortality in the elderly. South. Med. J. (1995) 88:721-724.
22. HIMES D: Protein-calorie malnutrition and involuntary weight loss: the role of aggressive nutritional intervention in wound healing. Ostomy Wound Manage. (1999) 45:46-55.
23. BRANDEIS G, MORRIS J, NASH D, LIPSITZ L: The epidemiology and natural history of pressure ulcers in elderly nursing home residents. JAMA (1990) 264:2905-2909.
24. CLAY M: Pressure sore prevention in nursing homes. Nurs. Stand. (2000) 14:45-50.
25. ROBINSON G, GOLDSTEIN M, LEVINE GM: Impact of nutritional status on DRG length of stay. J. Parenter. Enteral. Nutr. (1987) 11:49-51.
26. EDINGTON J, BOORMAN J, DURRANT ER et al.: Prevalence of malnutrition on admission to four hospitals in England. The Malnutrition Prevalence Group. Clin. Nutr. (2000) 19:191-195.
27. SMITH PE, SMITH AE: Nutritional intervention influences the bottom line. Healthc. Financial Manage. (1993) 47(10):30,32,34-36.
28. DEMLING RH, DESANTI L: The stress response to injury and infection: role of nutritional support. Wounds (2000) 12:3-14.
29. THOMAS DR: Prevention and treatment of pressure ulcers. What works? What doesn't? Cleve. Clin. J. Med. (2001) 68:704-722.
30. HIMES D: Strategies for managing involuntary weight loss. Adv. Skin Wound Care (2001) 11(Suppl. 1):7-12.
31. COLLINS N: Nutrition Q&A: the difference between albumin and prealbumin. Adv. Skin Wound Care (2001) 14:235-236.
32. JONES LM, A GOULDING A, GERRARD DF: DEXA: a practical and accurate tool to demonstrate total and regional bone loss, lean tissue loss and fat mass gain in paraplegia. Spinal Cord (1998) 36:637-640.
33. KRAMER J, KEARNEY M: Patient wound and treatment characteristics associated with healing in pressure ulcers. Adv. Skin Wound Care (2000) 113:14-24.
34. GIBBONS RB: Nutritional aspects of wound management. Home Health Care Consult. (2000) 7:19-22.
35. COLLINS N: Nutrition Q&A: estimating caloric needs to promote wound healing Adv. Skin Wound Care (2002) 15:140-141.
36. COLLINS N: Vitamin C and pressure ulcers. Adv. Skin Wound Care (2002) 15:186-188.
37. COLLINS N: Nutrition Q&A: arginine and wound healing. Adv. Skin Wound Care (2001) 14:16-17.
38. GRIFFITHS RD, JONES C, ALLAN PALMER TE: Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition. Nutrition (1997) 13:285-302.
39. WILLIAMS B, WATERS D, PARKER K: Evaluation and treatment of weight loss in adults with HIV disease. Am. Fam. Physician. (1999) 60:843-860.
40. COLLINS N, SCHAFER P: Appetite stimulants: an overview. Extend Care Prod. News (2002) 79:1.
41. CICERO LA: The nature and management of involuntary weight loss in the elderly. Consult. Pharm. (2001) 16(Suppl.):11-16.
42. YEH S-S, WU S-Y, LEE T-P et al.: Improvement in quality-of-life measures and stimulation of weight gain after treatment with megestrol acetate oral suspension in geriatric cachexia: results of a double-blind, placebo-oontrolled study. J. Am. Geriatr. Soc. (2000) 48:485-492.
43. DICKERSON LM, JONES KW: Retrospective review and intervention in the use of megestrol acetate in residents of skilled nursing facilities in South Carolina. Consult. Pharm. (2002) 17:1040-1044.
44. Bristol-Myers Sqibb: Megace® (megestrol acetate tablets) package insert. Bristol-Myers Sqibb, Princeton, NJ, USA February (2001).
45. Unimed Pharmaceuticals: Marinol® (dronabinol capsules) package insert. Unimed Pharmaceuticals, Deerfield, IL, USA (January 2001).
46. VOLICER L, STELLY M, MORRIS J, MCLAUGHLIN J, VOLICER BJ: Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease. Intl. J. Geriatr. Psychiatr. (1997) 12:913-919.
47. Organon Inc.: Remeron® SolTab® (mirtazapine tablets) package insert. Organon Inc., West Orange, NJ, USA (March 2001).
48. FAIRFIELD WP, TREAT M, ROSENTHAL DI et al.: Effects of testosterone and exercise on muscle leanness in eugonadal men with AIDS wasting. APStracts (2001) 8:0147A (Abstract).
49. SCHAMBELAN M, MULLIGAN K, GRUNFELD C et al.: Recombinant human growth hormone in patients with HIV-associated wasting. A randomised, placebo-controlled trial. Ann. Intern. Med. (1996) 125:873-882.
50. TAKALA J, RUOKONEN E, WEBSTER N et al.: Increased mortality associated with growth hormone treatment in critically ill adults. N. Engl. J. Med. (1999) 341:785-792.
51. BTG Pharmaceuticals: Oxandrin® (oxandrolone tablets, USP) package insert. BTG Pharmaceuticals, (December 2001).
52. SHEFFIELD-MOORE M, URBAN RJ, WOLF SE et al.: Short-term oxandrolone administration stimulates net muscle synthesis in young men. J. Clin. Endocrinol. Metab. (1999) 84:2705-2711.
53. FOX M, MINOT AS, LIDDLE GW: Oxandrolone: a potent anabolic steroid of novel chemical configuration. J. Clin. Endocrinol. Metab. (1962) 22:921-924.
54. DEMLING RH, DESANTI L: The rate of restoration of body weight after burn injury, using the anabolic agent oxandrolone, is not age dependent. Burns (2001) 17(Suppl.):46-51.
55. FISHER A, ABBATICOLA M: The effects of oxandrolone on body weight and composition in patients with HIV-associated weight loss. The Oxandrolone Study Group. Presented at: 5th Conference on Retroviruses and Opportunistic Infections February 1 - 5 (1998) Chicago, IL, USA Abstract: 477, Session 59.
56. STRAWFORD A, BARBIERI T, VAN LOAN M et al.: Resistance exercise and supraphysiologic androgen therapy in eugonadal men with HIV-related weight loss: a randomized controlled trial. JAMA (1999) 281:1282-1290.
57. DEMLING R, DE SANTI L: Closure of the 'non-healing wound' corresponds with correction of weight loss using the anabolic agent oxandrolone. Ostomy Wound Manage. (1998) 44:58-68.
58. CIOROIU M, HANAN SH: Adjuvant anabolic agents: a case report on the successful use of oxandrolone in an HIV-positive patient with chronic stasis ulceration. WOCN (2001) 28:215-218.
59. COLLINS N: Involuntary weight loss in the long-term care setting: a suggested nutritional intervention treatment algorithm. Wounds (2001) 13(Suppl. D):32D-37D.
60. BRESLOW RA, HALLFRISCH J, GUY DG et al.: The importance of dietary protein in healing pressure ulcers. J. Am. Geriatr. Soc. (1993) 41:357-362.
61. AFZAL NA, ADDAI S, FAGBEMI A, MURCH S, THOMSON M, HEUSCHKEL R: Refeeding syndrome with enteral nutrition in children: a case report, literature review and clinical guidelines. Clin. Nutr. (2002) 21:515-520.