The in vivo metabolism of 5-(4-nitrophenyl)-4-(2-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione in rats

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 28, Issue 2, 2003, Pages 113-118

  Oruc E E ^a   Kabasakal, L ^a   Rollas, S ^a  

^a MARMARA UNIVERSITY   (Turkey)

Author keywords

1,2,4 triazole 3 thione; In vivo metabolism; Rat

Indexed keywords

5 (4 NITROPHENYL) 4 (2 PHENYLETHYL) 2,4 DIHYDRO 3H 1,2,4 TRIAZOLE 3 THIONE; DRUG METABOLITE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DEALKYLATION; DRUG ACETYLATION; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MALE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; REDUCTION; ULTRAVIOLET SPECTROSCOPY;

EID: 0038780878     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03190498     Document Type: Article

References (11)

1. Eweiss NF., Bahajaj AA., Elsherbini EA. (1986): Synthesis of heterocycles. Part VI (1). Synthesis and antimicrobial activity of some 4-amino-5-aryl-1,2,4-triazole-3-thiones and their derivatives. J. Heterocyclic Chem., 23, 1451-1458.
2. Tsotinis A., Varvaresou A., Calogeropoulou T., Siatra-Papataikoudi T., Tiligada A. (1997): Synthesis and antimicrobial evaluation of indole containing derivatives of 1,3,4-thiadiazole, 1,2,4-triazole and their open-chain counterparts. Arzneim.-Forsch./Drug. Res., 47 (1), 307-310.
3. Mhasalkar MY., Shah MH., Nikam ST., Anantanarayanan KG., Deliwala CV. (1970):4-Alkyl-5-aryl-4H-1,2,4-triazole-3-thiols s hypoglysemic agents. J. Med. Chem., 13 (4), 672-674.
4. Rollas S., Kalyoncuoǧlu N., Sür-Altiner D., Yeǧenoǧlu Y. (1993): 5-(4-aminophenyl)-4-substituted-2,4-dihydro-3H-1,2,4-triazole-3-thiones: Synthesis and antibacterial and antifungal activities. Pharmazie, 48 (4), 308-309.
5. Holla BS., Poojary KN., Kalluraya B., Gowda PV. (1996): Synthesis, characterisation and antifungal activity of some N-bridged heterocycles derived from 3-(3-bromo-4-methoxyphenyl)-4-amino-5-mercapto-1,2,4-triazole. Farmaco, 51 (12), 793-799.
6. El-Emam AA., Ibrahim TM (1991): Synthesis and antiinflammatory and analgesic activity of some 3-(1-Adamantyl)-4-substituted-5-mercapto-1,2,4-triazoles. Arzneim-Forsch./Drug Res., 41 (12), 1260-1264.
7. Hosur MC., Talawor MB., Bennur RS., Bennur SC., Patil PA., Sambreakar S. (1993): Synthesis and antiinflamatory activity of 3-substituted-4-mercapto-4(H)-1,2,4-triazole. Indian J. Pharm. Sci., 55 (3), 86-90.
8. Oruç EE., Rollas S., Kabasakal L., Uysal MK. (1999): The in vivo metabolism of 5-(4-nitrophenyl)-4-phenyl-2,4-dihydro-3h-1,2,4-triazole-3-thione in rats. Drug Met. and Drug Int. 15, 127-140.
9. Kalyoncuoǧlu N., Rollas S., Sür-Altiner D., Yeǧenoǧlu Y., Anǧ Ö. (1992): 1-[p-(Benzoyl amino)benzoyl]-4-substituted thiosemicarbazides: Synthesis and antibacterial and antifungal activities. Pharmazie, 47 (10), 796-797.
10. Rollas S., Yilmaz N., Erdeniz H., Kiraz M. (1998): Antimicrobial activities of 5-(4-nitro/aminophenyl)-1,2,4-triazole-3-thione derivatives. Med. Sci. Res. 26, 83-84.
11. Gülerman N.N., Oruç E.E., Kartal F., Rollas S. (2000): The in vivo metabolism of 4-fluoro-benzoic acid [(5-nitro-2-furanyl)methylene] hydrazide in rats: Eur. J. Metab. Pharmacokinet., 25 (2), 103-108.