The in vivo metabolism of 5-(4-nitrophenyl)-4-phenyl-2,4-dihydro-3h- 1,2,4-triazole-3-thione in rats

Drug Metabolism and Drug Interactions

Volumn 15, Issue 2-3, 1999, Pages 127-140

  Oruç, Emine Elçin ^a   Rollas, Sevim ^a   Kabasakal, Levent ^a   Uysal, Meral Keyer ^a  

^a MARMARA UNIVERSITY   (Turkey)

Author keywords

1,2,4 triazoline 3 thione; In vivo metabolism; Rat

Indexed keywords

5 (4 ACETYLAMINOPHENYL) 2,4 DIHYDRO 4 PHENYL 3H 1,2,4 TRIAZOLE 3 THIONE; 5 (4 NITROPHENYL) 2,4 DIHYDRO 4 PHENYL 3H 1,2,4 TRIAZOLE 3 THIONE; ACETIC ANHYDRIDE; THIOKETONE; UNCLASSIFIED DRUG;

ALGORITHM; BIOTRANSFORMATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONFERENCE PAPER; DRUG ACETYLATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAPERITONEAL DRUG ADMINISTRATION; LABORATORY; MALE; METABOLISM; NONHUMAN; RAT; REACTION ANALYSIS; REDUCTION; SYNTHESIS;

EID: 0032956223     PISSN: 07925077     EISSN: None     Source Type: Journal    
DOI: 10.1515/DMDI.1999.15.2-3.127     Document Type: Conference Paper

References (16)

1. Kane JM, Dudlay MW, Sorensen SM, Miller FP. 2,4-Dihydro-3H-1,2,4-triazole-3-thiones as potential antidepressant agents. J Med Chem 1998; 31: 1253-1258.
2. Kömürcü ŞG, Rollas S, Yilmaz N, Çevikbaş A. Synthesis of 3-methyl-4-[(2, 4-dihydro-4-substituted-3H-1,2,4-triazole-3-thione-5-yl) phenylhydrazone]-5-isoxazolone and evaluation of their antimicrobial activities. Drug Metab Drug Interact 1995; 12: 161-169.
3. Pathak US, Devani MB, Shishoo CJ, Shah SA. Synthesis of 5-aryl-3-mercapto-4-substituted triazoles. Indian J Chem 1989; 28 B: 83-86.
4. Ebeid MY, Al-Ashmawi MI, Abbas SE, Abu-Kull MM. Synthesis of some S-triazole derivatives from ibuprofen as potential antiinflammatory agents. Egypt J Pharm Sci 1989; 30: 399-409.
5. Mullican MD, Wilson WW, Connor DT, Kostlan CR, Schrier DJ, Dyer RD. Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, 1,3,4-oxadiazoles, and 1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents. J Med Chem 1993; 36: 1090-1099.
6. Shah MH, Mhasalkar MY, Patki VM, Deliwala CV, Sheth UK. New 1,2,4(H) triazole derivatives as diuretic agents. J Pharm Sci 1969; 58: 1398-1401.
7. Mhasalkar MY, Shah MH, Nikam ST, Anantanarayan KG, Deliwala CV. Further studies in substituted 4H-1,2,4-triazoles for possible hypoglycemic activity. J Med Chem 1971; 14: 260-262.
8. Kumamota T, Toyooka K, Nishida M, Kuwahara H, Yoshimura Y, Kawada J, Kubota S. Effect of 2,4-dihydro-3H-1,2,4-triazole-3-thiones and thiosemicarbazones on iodide uptake by the mouse thyroid: the relationship between their structure and antithyroid activity. Chem Pharm Bull 1990; 38: 2595-2596.
9. Rollas S, Kalyoncuoglu N, Sur-Altiner D, Yegenoglu Y. 5-(4-Aminophenyl)-4-substituted-2,4-dihydro-3H-1,2,4-triazole-3-thiones: Synthesis and antibacterial and antifungal activities. Pharmazie 1993; 48: 308-309.
10. Kalyoncuoǧlu N, Rollas S, Sür-Altiner D, Yeǧenoǧlu Y, Anǧ Ö. l-[p-(Benzoylamino)benzoyl]-4-substituted thiosemicarbazides: Synthesis and antibacterial and antifungal activities. Pharmazie, 1992; 47: 796-797.
11. Gülerman N, Rollas S, Ülgen M, Gorrod JW. Synthesis and evaluation of some substituted 1,3,4-thiadiazole derivatives. Boll Chim Farmaceutico Anno 1995; 134: 461-463.
12. Parmar SS, Gupta AK, Gupta TK, Stenberg VI. Synthesis of substituted benzylidinohydrazines and their monoamine oxidase inhibitory and anticonvulsant properties. J Pharm Sci 1975; 64: 154-157.
13. Rollas S. Reductive cleavage of azo compounds with hydrazine hydrate and some new 1,2,4-triazole derivatives IL M.Ü. Fen Bilimleri Dergisi 1986; 3: 195-200.
14. Rollas S, Yilmaz N, Erdeniz H, Kiraz M. Antimicrobial activities of 5-(4-nitro/aminophenyl)-1,2,4-triazole-3-thione derivatives. Med Sci Res 1998, 26: 83-84.
15. Rollas S. Synthesis and spectrometric analysis of some 1,2,4-triazole-5-thiones. J Fac Pharm Istanbul 1981; 17: 155-163.
16. Rollas S, Doǧan N, Ülgen M, Özger Y. Synthesis and spectrometric analysis of some new azopyrazole substituted 1,2,4-triazole-5-thiones. J Pharm Univ Mar 1990; 6: 41-47.