Increased levels of advanced glycation end products in human cataractous lenses

Journal of Cataract and Refractive Surgery

Volumn 29, Issue 5, 2003, Pages 998-1004

  Franke, Sybille ^a   Dawczynski, Jens ^a   Strobel, Jürgen ^a   Niwa, Toshimitsu ^b   Stahl, Peter ^c   Stein, Günter ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b NAGOYA UNIVERSITY HOSPITAL   (Japan)

^c ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

6 N CARBOXYMETHYLLYSINE; ADVANCED GLYCATION END PRODUCT; IMIDAZOLE DERIVATIVE; IMIDAZOLONE; PENTOSIDINE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CATARACT; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LENS; PRIORITY JOURNAL;

EID: 0038779570     PISSN: 08863350     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0886-3350(02)01841-2     Document Type: Article

References (15)

1. Stitt AW. Advanced glycation: an important pathological event in diabetic and age related ocular disease. Br J Ophthalmol 2001; 85:746-753
2. Shamsi FA, Lin K, Sady C, Nagaraj RH. Methylglyoxalderived modifications in lens aging and cataract formation. Invest Ophthalmol Vis Sci 1998; 39:2355-2364
3. Boscia F, Grattagliano I, Vendemiale G, et al. Protein oxidation and lens opacity in humans. Invest Ophthalmol Vis Sci 2000; 41:2461-2465
4. Crabbe MJC. Cataract as a conformational disease - the Maillard reaction, alpha-crystallin and chemotherapy. Cell Mol Biol 1998; 44:1047-1050
5. Miyata T, Ueda Y, Shinzato T, et al. Accumulation of albumin-linked and free-form pentosidine in the circulation of uremic patients with end-stage renal failure: renal implications in the pathophysiology of pentosidine. J Am Soc Nephrol 1996; 7:1198-1206
6. Niwa T, Katsuzaki T, Miyazaki S, et al. Immunhistochemical detection of imidazolone, a novel advanced glycation end product, in kidneys and aortas of diabetic patients. J Clin Invest 1997; 99:1272-1280
7. Dunn JA, Patrick JS, Thorpe SR, Baynes JW. Oxidation of glycated proteins: age-dependent accumulation of N epsilon (carboxymethyl) lysine in lens proteins. Biochemistry 1989; 28:9464-9468
8. Lyons TJ, Silvestri G, Dunn JA, et al. Role of glycation in modification of lens crystallins in diabetic and nondiabetic senile cataracts. Diabetes 1991; 40:1010-1015
9. Saxena P, Saxena AK, Cui X-L, et al. Transition metalcatalyzed oxidation of ascorbate in human cataract extracts: possible role of advanced glycation end products. Invest Ophthalmol Vis Sci 2000; 41:1473-1481
10. Wells-Knecht KJ, Brinkmann E, Wells-Knecht MC, et al. New biomarkers of Maillard reaction damage to proteins. Nephrol Dial Transplant 1996; 11(suppl 5): 41-47
11. Nagaraj RH, Sell DR, Prabhakaram M, et al. High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lenssenescence and cataractogenesis. Proc Natl Acad Sci USA 1991; 88:10257-10261
12. Lee K-W, Mossine V, Ortwerth BJ. The relative ability of glucose and ascorbate to glycate and crosslink lens proteins in vitro. Exp Eye Res 1998; 67:95-104
13. Hayase F, Konishi Y, Kato H. Identification of the modified structure of arginine residues in proteins with 3-deoxyglucosone, a Maillard reaction intermediate. Biosci Biotech Biochem 1995; 59:1404-1411
14. Zarina S, Zhao HR, Abraham EC. Advanced glycation end products in human senile and diabetic cataractous lenses. Mol Cell Biochem 2000; 210:29-34
15. Hashimoto H, Arai K, Yoshida S, et al. Pentosidine and autofluorescence in lenses of diabetic patients. Jpn J Ophthalmol 1997; 41:274-277