A kinetic oxymoron: Concentration-dependent first-order rate constants for hydrolysis of ceftazidime

Journal of Pharmaceutical Sciences

Volumn 87, Issue 1, 1998, Pages 53-58

  Fubara, Josephine O ^a   Notari, Robert E ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CEFTAZIDIME;

ARTICLE; CATALYSIS; DIMERIZATION; DRUG DEGRADATION; DRUG HYDROLYSIS; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 0031889315     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1021/js970179k     Document Type: Article

References (23)

1. Bundgaard, H. Polymerization of Penicillins: Kinetics and Mechanism of Di-and Polymerization of Ampicillin in Aqueous Solution. Acta Pharm. Suec. 1976, 13, 9-26.
2. Bundgaard, H. Polymerization of Penicillins: II Kinetics and Mechanism of Dimerization and Self-Catalyzed Hydrolysis of Amoxycillin in Aqueous Solution. Acta Pharm. Suec. 1977, 14, 47-66.
3. Bundgaard, H. Polymerization of Penicillins: III Structural Effects Influencing Rate of Dimerization of Amino-Penicillins in Aqueous Solution. Acta Pharm. Suec. 1977, 14, 67-80.
4. Bundgaard, H.; Larsen, C. Polymerization of Penicillins: IV Separation, Isolation and Characterization of Ampicillin Polymers formed in Aqueous Solution. J. Chromatogr. 1977, 132, 51-59.
5. Dewdney, J. M.; Smith, H.; Wheeler, A. W. The Formation of Antigenic Polymers in Aqueous Solutions of β-Lactam Antibiotics. Immunology 1971, 21, 517-525.
6. Smith, H.; Dewdney, J. M.; Wheeler, A. W. A Comparison of the Amounts and the Antigenicity of Polymeric Materials Formed in Aqueous Solution by Some β-Lactam Antibiotics. Immunology 1971, 21, 527-533.
7. Smith, H.; Marshall, A. C. Polymers Formed by Some β-Lactam Antibiotics. Nature (London) 1971, 232, 45-46.
8. Bundgaard, H. Penicillin Allergy: Kinetics of Penicilloylation of Serum Albumins by Various Penicillins. Acta Pharm. Suec. 1977, 14, 391-402.
9. Zhang, Q. Polymerization Properties of Cefotaxime. Chung-Kuo Kang Sheng Su Tsa Chih. 1992, 17, 428-434.
10. Tazicef. In Physicians' Desk Reference, 51st ed.; Medical Economics Company Inc.: Montvale, NJ, 1997; pp 2697-2701.
11. Zhou, M.; Notari, R. E. Influence of pH, Temperature and Buffers on the Kinetics of Ceftazidime Degradation in Aqueous Solutions. J. Pharm. Sci. 1993, 5, 534-538.
12. Coene, B.; Schanck, A.; Dereppe, J-M.; VanMeerssche, M. Substituent Effects on Reactivity and Spectral Parameters of Cephalosporins. J. Med. Chem. 1984, 27, 694-700.
13. Sugioka, T.; Asano, T.; Chikaraishi, Y.; Suzuki, E.; Sano, A.; Kuriki, T.; Shirotsuka, M.; Saito, K. Stability and Degradation Pattern of Cefpirome (HR 810) in Aqueous Solution. Chem. Pharm. Bull. 1990, 38, 1998-2002.
14. Connors, K. A. Simple Rate Equations. Chemical Kinetics; VCH: New York, 1990; pp 18-21.
15. Yamaha, T.; Tsuji, A. Comparative Stability of Cephalosporins in Aqueous Solution: Kinetics and Mechanisms of Degradation. J. Pharm. Sci. 1976, 65, 1563-1573.
16. Faraci, W. S.; Pratt, R. F. Elimination of a Good Leaving Group From the 3′-Position of a Cephalosporin Need Not Be Concerted With β-Lactam Ring Opening: TEM-2 β-Lactamase-Catalyzed Hydrolysis of Pyridine-2-azo-4′-(N′,N′-dimet hylaniline) Cephalosporin (PADAC) and of Cephaloridine. J. Am. Chem. Soc. 1984, 106, 1489-1490
17. Itakura, K; Aoki, I; Kasahara, F; Nishikawa, M; Mizushima, Y. Structures of Polymers Formed in Aqueous Solutions of Cefsulodin Sodium. Chem. Pharm. Bull. 1981, 29, 1655-1661.
18. Boyd, D. B.; Lunn, W. H. W. Electronic Structures of Cephalosporins and Penicillins. 9. Departure of a Leaving Group in Cephalosporins. J. Med. Chem. 1979, 22, 778-783, and refs 1-15 cited therein.
19. Wang, D.; Notari, R. E. Cefuroxime Hydrolysis Kinetics and Stability Predictions in Aqueous Solutions. J. Pharm. Sci. 1994, 83, 577-581.
20. Ceftazidime. In AHFS Drug Information 94; McEvoy, G. K., Ed.; American Society of Hospital Pharmacists Inc.: Bethesda, MD, 1994; pp 130-138.
21. Kaiser, G. V.; Kukolja, S. Modifications of the β-Lactam System. In Cephalosporins and Penicillins; Chemistry and Biology, Flynn, E. H., Ed.; Academic Press: New York, 1972; pp 125-128.
22. Namiki, Y.; Tanabe, T.; Kobayashi, T., Tanabe, J.; Okimura, Y.; Koda, S.; Morimoto, Y. Degradation Kinetics and Mechanisms of a New Cephalosporin, Cefixime, in Aqueous Solution. J. Pharm. Sci. 1987, 76, 208-214.
23. Parker, V. Inverse Temperature Effects and Concentration Dependent Apparent First-Order Rate Constants in Complex Ion Radical Reactions. Acta Chem. Scand. B 1981, 35, 123-129.