Regulation of multiple tumor microenvironment markers by overexpression of single or paired combinations of ErbB receptors

Cancer Research

Volumn 63, Issue 13, 2003, Pages 3764-3774

  Alaoui Jamali, Moulay A ^a,b   Song, Daniel J ^a   Benlimame, Naciba ^a   Yen, Lily ^a   Deng, Xiaoming ^a   Hernandez Perez, Maite ^a   Wang, Taiqi ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; THROMBOSPONDIN 1; TUMOR MARKER; TYROSINE KINASE RECEPTOR;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL STRUCTURE; EXTRACELLULAR MATRIX; GENE CONTROL; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; TUMOR VASCULARIZATION; UNINDEXED SEQUENCE;

3T3 CELLS; ANIMALS; BLOTTING, NORTHERN; BREAST NEOPLASMS; DNA PRIMERS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, NUDE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; RECEPTOR, ERBB-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; TRANSCRIPTION, GENETIC; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0038756362     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Yarden, Y., and Sliwkowski, M. X. Untangling the ErbB signalling network. Nat. Rev. Mol. Cell Biol., 2: 127-137, 2001.
2. Olayioye, M. A., Neve, R. M., Lane, H. A., and Hynes, N. E. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J., 19: 3159-3167, 2000.
3. Sandgren, E. P., Luetteke, N. C., Palmiter, R. D., Brinster, R. L., and Lee, D. C. Overexpression of TGF-α in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell, 61: 1121-1135, 1990.
4. Jhappan. C., Stahle, C., Harkins, R. N., Fausto, N., Smith, G. H., and Merlino, G. T. TGF-α overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell, 61: 1137-1146, 1990.
5. Matsui, Y., Halter, S. A., Holt, J. T., Hogan, B. L., and Coffey, R. J. Development of mammary hyperplasia and neoplasia in MMTV-TGF-α transgenic mice. Cell, 61: 1147-1155, 1990.
6. Krane, I. M., and Leder, P. NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice. Oncogene, 12: 1781-1788, 1996.
7. O'Shea, S., Johnson, K., Clark, R., Sliwkowski, M. X., and Erickson, S. L. Effects of in vivo heregulin β1 treatment in wild-type and ErbB gene-targeted mice depend on receptor levels and pregnancy. Am. J. Pathol., 158: 1871-1880, 2001.
8. Wang, S. C., Zhang, L., Hortobagyi, G. N., and Hung, M. C. Targeting HER2: recent developments and future directions for breast cancer patients. Semin. Oncol., 28: 21-29, 2001.
9. Nicholson, R. I., Gee, J. M., and Harper, M. E. EGFR and cancer prognosis. Eur. J. Cancer, 37 (Suppl. 4): S9-S15, 2001.
10. Dittadi, R., and Gion, M. More about: prognostic importance of low c-erbB2 expression in breast tumors. J. Natl. Cancer Inst. (Bethesda), 92: 1443-1444, 2000.
11. Ferrero-Pous, M., Hacene, K., Tubiana-Hulin, M., and Spyratos, F. Re: Prognostic importance of low c-erbB2 expression in breast tumors. J. Natl. Cancer Inst. (Bethesda), 91: 1584-1585, 1999.
12. Koscielny, S., Terrier, P., Spielmann, M., and Delarue, J. C. Prognostic importance of low c-erbB2 expression in breast tumors. J. Natl. Cancer Inst. (Bethesda), 90: 712, 1998.
13. Piffanelli, A., Dittadi, R., Catozzi, L., Gion, M., Capitanio, G., Gelli, M. C., Brazzale, A., Malagutti, R., Pelizzola, D., Menegon, A., Giovannini, G., and Gardini, G. Determination of ErbB2 protein in breast cancer tissues by different methods. Relationships with other biological parameters. Breast Cancer Res. Treat., 37: 267-276, 1996.
14. Bozcuk, H., Uslu, G., Pestereli, E., Samur, M., Ozdogan, M., Karaveli, S., Sargin, F., and Savas, B. Predictors of distant metastasis at presentation in breast cancer: a study also evaluating associations among common biological indicators. Breast Cancer Res. Treat., 68: 239-248, 2001.
15. Albanell, J., and Baselga, J. Unraveling resistance to trastuzumab (Herceptin): insulin-like growth factor I receptor, a new suspect. J. Natl. Cancer Inst. (Bethesda), 93: 1830-1832, 2001.
16. Cameiro, F., and Sobrinho-Simoes, M. The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas. Cancer (Phila.), 88: 238-240, 2000.
17. Mirza, A. N., Mirza, N. Q., Vlastos, G., and Singletary, S. E. Prognostic factors in node-negative breast cancer: a review of studies with sample size more than 200 and follow-up more than 5 years. Ann. Surg., 235: 10-26. 2002.
18. Chow, N. H., Chan, S. H., Tzai, T. S., Ho, C. L., and Liu, H. S. Expression profiles of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder. Clin. Cancer Res., 7: 1957-1962, 2001.
19. Porebska, I., Harlozinska, A., and Bojarowski, T. Expression of the tyrosine kinase activity growth factor receptors (EGFR, ERB B2, ERB B3) in colorectal adenocarcinomas and adenomas. Tumour Biol., 21: 105-115, 2000.
20. Suo, Z., Risberg, B., Kalsson, M. G., Willman, K., Tierens, A., Skovlund, E., and Nesland, J. M. EGFR family expression in breast carcinomas, c-erbB-2 and c-erbB-4 receptors have different effects on survival. J. Pathol., 196: 17-25, 2002.
21. Xia, W., Lau, Y. K., Zhang, H. Z., Xiao, F. Y., Johnston, D. A., Liu, A. R., Li, L., Katz, R. L., and Hung, M. C. Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members. Clin. Cancer Res., 5: 4164-4174, 1999.
22. Gilbertson, R. J., Perry, R. H., Kelly, P. J., Pearson, A. D., and Lunec, J. Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma. Cancer Res., 57: 3272-3280, 1997.
23. Gilmour, L. M., Macleod, K. G., McCaig, A., Gullick, W. J., Smyth, J. F., and Langdon, S. P. Expression of erbB-4/HER-4 growth factor receptor isoforms in ovarian cancer. Cancer Res., 61: 2169-2176, 2001.
24. Alimandi, M., Romano, A., Curia, M. C., Muraro, R., Fedi, P., Aaronson, S. A., Di Fiore, P. P., and Kraus, M. H. Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. Oncogene, 10: 1813-1821, 1995.
25. Siegel, P. M., Ryan, E. D., Cardiff, R. D., and Muller, W. J. Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer. EMBO J., 18: 2149-2164, 1999.
26. Lemoine, N. R., Barnes, D. M., Hollywood, D. P., Hughes, C. M., Smith, P., Dublin, E., Prigent, S. A., Gullick, W. J., and Hurst, H. C. Expression of the ERBB3 gene product in breast cancer. Br. J. Cancer, 66: 1116-1121, 1992.
27. Naidu, R., Yadav, M., Nair, S., and Kutty, M. K. Expression of c-erbB3 protein in primary breast carcinomas. Br. J. Cancer, 78: 1385-1390, 1998.
28. Furger, C., Fiddes, R. J., Quinn, D. I., Bova, R. J., Daly, R. J., and Sutherland, R. L. Granulosa cell tumors express erbB4 and are sensitive to the cytotoxic action of heregulin-β2/PE40. Cancer Res., 58: 1773-1778, 1998.
29. Srqinivasan, R., Poulsom, R., Hurst, H. C., and Gullick, W. J. Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types. J. Pathol., 185: 236-245, 1998.
30. Yen, L., You, X. L., AI Moustafa, A. E., Batist, G., Hynes, N. E., Mader, S., Meloche, S., and Alaoui-Jamali, M. A. Heregulin selectively up-regulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis. Oncogene, 19: 3460-3469, 2000.
31. Jaitovich-Groisman, I., Benlimame, N., Slagle, B. L., Perez, M. H., Alpert, L., Song, D. J., Fotouhi-Ardakani, N., Galipeau, J., and Alaoui-Jamali, M. A. Transcriptional regulation of the TFIIH transcription repair components XPB and XPD by the hepatitis B virus x protein in liver cells and transgenic liver tissue. J. Biol. Chem., 276: 14124-14132, 2001.
32. Novak, J. P., Sladek, R., and Hudson, T. J. Characterization of variability in large-scale gene expression data: implications for study design. Genomics, 79: 104-113, 2002.
33. Yen, L., Benlimame, N., Nie, Z. R., Xiao, D., Wang, T., Moustafa, A. E., Esumi, H., Milanini, J., Hynes, N. E., Pages, G., and Alaoui-Jamali, M. A. Differential regulation of tumor angiogenesis by distinct ErbB homo- and heterodimers. Mol. Biol. Cell, 13: 4029-4044, 2002.
34. Yoo, J. Y., and Hamburger, A. W. Interaction of the p23/p198 protein with ErbB-3. Gene (Amst.), 229: 215-221, 1999.
35. Penington, D. J., Bryant, I., and Riese, D. J. Constitutively active ErbB4 and ErbB2 mutants exhibit distinct biological activities. Cell Growth Differ., 13: 247-256, 2002.
36. Cohen, B. D., Kiener, P. A., Green, J. M., Foy, L., Fell, H. P., and Zhang, K. The relationship between human epidermal growth-like factor receptor expression and cellular transformation in NIH3T3 cells. J. Biol. Chem., 271: 30897-30903, 1996.
37. Hellyer, N. J., Cheng, K., and Koland, J. G. ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase. Biochem. J., 333 (Pt. 3): 757-763, 1998.
38. Lee, R. J., Albanese, C., Fu, M., D'Amico, M., Lin, B., Watanabe, G., Haines, G. K., III, Siegel, P. M., Hung, M. C., Yarden, Y., Horowitz, J. M., Muller, W. J., and Pestell, R. G. Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway. Mol. Cell. Biol., 20: 672-683, 2000.
39. Sweeney, C., Fambrough, D., Huard, C., Diamonti, A. J., Lander, E. S., Cantley, L. C., and Carraway, K. L., III. Growth factor-specific signaling pathway stimulation and gene expression mediated by ErbB receptors. J. Biol. Chem., 276: 22685-22698, 2001.
40. Heppner, G. H., and Miller, F. R. The cellular basis of tumor progression. Int. Rev. Cytol., 177: 1-56, 1998.
41. Bowden, E. T., Barth, M., Thomas, D., Glazer, R. I., and Mueller, S. C. An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation. Oncogene, 18: 4440-4449, 1999.
42. Coussens, L. M., Tinkle, C. L., Hanahan, D., and Werb, Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell, 103: 481-490, 2000.
43. Nakahara, H., Howard, L., Thompson, E. W., Sato, H., Seiki, M., Yeh, Y., and Chen, W. T. Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion. Proc. Natl. Acad. Sci. USA, 94: 7959-7964, 1997.
44. Sternlicht, M. D., Lochter, A., Sympson, C. J., Huey, B., Rougier, J. P., Gray, J. W., Pinkel, D., Bissell, M. J., and Werb, Z. The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell, 98: 137-146, 1999.
45. Werb, Z. ECM and cell surface proteolysis: regulating cellular ecology. Cell, 91: 439-442, 1997.
46. Kauraniemi, P., Barlund, M., Monni, O., and Kallioniemi, A. New amplified and highly expressed genes discovered in the ERBB2 amplicon in breast cancer by cDNA microarrays. Cancer Res., 61: 8235-8240, 2001.
47. Sorlie, T., Perou, C. M., Tibshirani, R., Aas, T., Geisler, S., Johnsen, H., Hastie, T., Eisen, M. B., van de Rijn, M., Jeffrey, S. S., Thorsen, T., Quist, H., Matese, J. C., Brown, P. O., Botstein, D., Eystein, L. P., and Borresen-Dale, A. L. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. USA, 98: 10869-10874, 2001.
48. Chen, H., Hemdon, M. E., and Lawler, J. The cell biology of thrombospondin-1. Matrix Biol., 19: 597-614, 2000.
49. Zhang, Y., Deng, Y., Luther, T., Muller, M., Ziegler, R., Waldherr, R., Stem, D. M., and Nawroth, P. P. Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice. J. Clin. Investig., 94: 1320-1327, 1994.
50. Adams, J. C. Thrombospondins: multifunctional regulators of cell interactions. Annu. Rev. Cell Dev. Biol., 17: 25-51, 2001.
51. de Fraipont, F., Nicholson, A. C., Feige, J. J., and Van Meir, E. G. Thrombospondins and tumor angiogenesis. Trends Mol. Med., 7: 401-407, 2001.
52. Sargiannidou, I., Zhou, J., and Tuszynski, G. P. The role of thrombospondin-1 in tumor progression. Exp. Biol. Med. (Maywood), 226: 726-733, 2001.
53. Bornstein, P. Thrombospondins: structure and regulation of expression. FASEB J., 6: 3290-3299, 1992.