Structure-activity relationships of first bishydroxymethyl-substituted cage dimeric 4-aryl-1,4-dihydropyridines as HIV-1 protease inhibitors

European Journal of Medicinal Chemistry

Volumn 38, Issue 5, 2003, Pages 495-499

  Hilgeroth, Andreas ^a   Lilie, Hauke ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Binding region; Cage dimeric 4 aryl 1,4 dihydropyridines; HIV 1 protease inhibitor

Indexed keywords

1,7 DIHYDROXYMETHYL 3,9 DIMETHOXYCARBONYL 6,12 DIPHENYL 3,9 DIAZAHEXACYCLO[6.4 0.0 2.7 .0 4.11 .0 5.10 ]DODECANE; 1,7 DIHYDROXYMETHYL 6,12 DIPHENYL 3,9 DIPHENOXYCARBONYL 3,9 DIAZAHEXACYCLO[6.4.0.0 2.7 .0 4.11 .0 5.10 ]DODECANE; 3,9 BIS TERT BUTOXYCARBONYL 1,7 DIHYDROXYMETHYL 6,12 DIPHENYL 3,9 DIAZAHEXACYCLO[6.4.0.0 2.7 .0 4.11 .0 5.10 ]DODECANE; 3,9 DIACETYL 1,7 DIHYDROXYMETHYL 6,12 DIPHENYL 3,9 DIAZAHEXACYCLO[6.4.0.0 2.7 .0 4.11 .0 5.10 ]DODECANE; DIMER; DODECANE; FUNCTIONAL GROUP; METHYL GROUP; PROTEINASE INHIBITOR; PYRIDINE DERIVATIVE; SAQUINAVIR; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CYTOPATHOGENIC EFFECT; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME SUBUNIT; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; METHYLATION; PROTEINASE INHIBITION; SPECTROMETRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

EID: 0038736975     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(03)00060-6     Document Type: Article

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