Critical investigation of coupled liquid chromatography-NMR spectroscopy in pharmaceutical impurity identification

Magnetic Resonance in Chemistry

Volumn 41, Issue 6, 2003, Pages 448-454

  Sharman, Gary J ^a   Jones, Ian C ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Liquid chromatography NMR; NMR; Pharmaceutical impurities

Indexed keywords

IMPURITIES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

CLASSICAL APPROACH; IMPURITIES IDENTIFICATION; LIQUID CHROMATOGRAPHY-NMR; NMR-SPECTROSCOPY; PEAK BROADENING; PHARMACEUTICAL IMPURITY;

LIQUID CHROMATOGRAPHY;

ACCURACY; ARTICLE; DEGRADATION; ISOLATION PROCEDURE; LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PURIFICATION;

EID: 0038731289     PISSN: 07491581     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrc.1196     Document Type: Article

References (11)

1. Lindon JC, Nicholson JK, Wilson ID. Prog. Nucl. Magn. Reson. Spectrosc. 1996; 29: 1.
2. Albert K. Anal.-Taschenb. 1999; 20: 107.
3. Albert K. (ed). LC-NMR and Related Techniques. Wiley: Chichester, 2002.
4. Palmer AG III, Cavanagh J, Wright PE, Rance M. J. Magn. Reson. 1991; 93: 151.
5. Kay LE, Keifer P, Saarinen T. J. Am. Chem. Soc. 1992; 114: 10 663.
6. Sweatman BC, Farrant RD, Sanderson PN, Philippe I, Salman SR, Nicholson JK, Lindon JC. J. Magn. Reson. Anal. 1995; 1: 9.
7. Griffiths L, Horton R. Magn. Reson. Chem. 1998; 36: 104.
8. Strohschein S, Pursch M, Lubda D, Albert K. Anal. Chem. 1998; 70: 13.
9. Kuhn T. In Bruker User's Meeting, Coventry, 2001.
10. Schlotterbeck G, Tseng L-H, Haendel H, Braumann U, Albert K. Anal. Chem. 1997; 69: 1421.
11. Wu N, Peck TL, Webb AG, Magin RL, Sweedler JV. J. Am. Chem. Soc. 1994; 116: 7929.