Distribution and anti-HBV effects of antisense oligodeoxynu-cleotides conjugated to galactosylated poly-L-lysine

World Journal of Gastroenterology

Volumn 9, Issue 6, 2003, Pages 1251-1255

  Zheng, Su Jun ^b   Zhong, Sen ^a   Zhang, Jian Jun ^b   Chen, Feng ^a   Ren, Hong ^b   Deng, Cun Liang ^a  

^a SOUTHWEST MEDICAL UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; GALACTOSYL POLYLYSINE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; PHOSPHOROTHIOIC ACID DERIVATIVE; PHOSPHORUS 32; POLYLYSINE; POLYNUCLEOTIDE 5' HYDROXYL KINASE; UNCLASSIFIED DRUG; VIRUS DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG EFFECT; DRUG HALF LIFE; DRUG INHIBITION; DRUG LABELING; DRUG LIVER LEVEL; DRUG STABILITY; DRUG SYNTHESIS; GENE EXPRESSION; GENETIC TRANSFECTION; HEPATITIS B; HEPATITIS B VIRUS; IN VITRO STUDY; IN VIVO STUDY; LIVER; LIVER CELL; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; SEQUENCE ANALYSIS; TRANSGENIC MOUSE; VIRUS CULTURE; VIRUS EXPRESSION; VIRUS INHIBITION; VIRUS LOAD; VIRUS REPLICATION;

EID: 0038728063     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v9.i6.1251     Document Type: Article

References (36)

1. Jensen KD, Kopeckova P, Kopecek J. Antisence oligonucleotides delivered to the lysosome escape and actively inhibit the hepatitis B virus. Bioconjug Chem 2002; 13: 975-984
2. Liu S, Sun W, Cao Y. Study on anti-HBV effects by antisense oligodeoxynucleotides in vitro. Zhonghua Yufang Yixue Zazhi 2001; 35: 338-340
3. Robaczewska M, Guerret S, Remy JS, Chemin I, Offensperger WB, Chevallier M, Behr JP, Podhajska AJ, Blum HE, Trepo C, Cova L. Inhibition of hepadnaviral replication by polyethylenimine-based intravenous delivery of antisense phosphodiester oligodeoxynucleotides to the liver. Gene Ther 2001; 8: 874-881
4. Soni PN, Brown D, Saffie R, Savage K, Moore D, Gregoriadis G, Dusheiko GM. Biodistribution, stability, and antiviral efficacy of liposome-entrapped phosphorothioate antisense oligodeoxynucleotides in ducks for the treatment of chronic duck hepatitis B virus infection. Hepatology 1998; 28: 1402-1410
5. Sells MA, Chen ML, Acs G. Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA. Proc Natl Acad Sci USA 1987; 84: 1005-1009
6. Acs G, Sells MA, Purcell RH, Price P, Engle R, Shapiro M, Proper H. Hepatitis B virus produced by transfected Hep G2 cells causes hepatitis in chimpanzees. Proc Natl Acad Sci USA 1987; 84: 4641-4644
7. Sells MA, Zelent AZ, Shvartsman M, Acs G. Replicative intermediates of hepatitis B virus in Hep G2 cells that produce infectious virions. J Virol 1988; 62: 2836-2844
8. Schwartz BA, Gray GR. Proteins containing reductively aminated dissacharides. Synthesis and chemical characterization. Arch Biochem Biophys 1977; 181: 542-549
9. Zhong Z, Zhang D, Wen S. Inhibition of hepatitis B viral gene expression and replication in vitro by targeted antisense oligonucleotides. Zhonghua Yixue Zazhi 1995; 75: 392-395, 444
10. Xiong Y, Jia Y, Wang H, Liu G, Ren H, Zhou YZ, Zhang D. Hepatitis B virus transgenic micefor the model of anti-hepatitis B virus drug study. Zhonghua Ganzangbing Zazhi 2001; 9: 19-21
11. Xiong YL, Jia YZ, Wang HM, Liu GZ, Zhang YJ. High-level hepatitis B virus expression in transgenic mice. Chuanranbing Xinxi 2000; 13: 164-165
12. Miller RH, Kaneko S, Chung CT, Girones R, Purcell RH. Compact organization of the hepatitis B virus genome. Hepatology 1989: 9: 322-327
13. Galibert F, Monadart E, Fitoussi F, Fiollais P, Charnay P. Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature 1979; 281: 646-650
14. Wu CH, Wilson JM, Wu GY. Targeting genes: Delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo. J Biol Chem 1989; 264: 16985-16987
15. Lu XM, Fischman AJ, Jyawook SL, Hendricks K, Tompkins RG, Yarmusch ML. Antisense DNA delivery in vivo: Liver targeting by receptor mediated uptake. J Nucl Med 1994; 35: 269-275
16. Nakazono K, Ito Y, Wu CH, Wu GY. Inhibition of hepatitis B virus replication by targeted pretreatment of complexes antisense DNA in vitro. Hepatology 1996; 23: 1297-1303
17. Wu GY, Walton CM, Wu CH. Targeted polynucleotides for inhibition of hepatitis B and C viruses. Croat Med J 2001; 42: 463-466
18. Wu GY, Wu CH. Specific inhibition of hepatitis B viral gene expression in vitro by targeted antisence oligonucleotides. J Biol Chem 1992; 267: 12436-12439
19. Martinez Fong D, Mullersman JE, Purchio AF, Armendariz Borunda J, Martinez Hernanddez A. Nonenzymatic glycosylation of poly-L-lysine: A new tool for targeted gene delivery. Hepatology 1994; 20: 1602-1608
20. Guo J, Zhou YX, Yao ZQ, Wang SQ, Weng SM, Wang BC. Specific delivery to liver cells by asialoglycoprotein modified antisense oligodeoxynucleotides in vitro and in vivo. Zhonghua Chuanranbing Zazhi 1997; 15: 16-19
21. Dini L, Falasca L, Lentini A, Mattioli P, Piacentini M, Piredda L, Autuo Ri F. Galactose specific receptor modulation related to the onset of apoptosis in rat liver. Eur J Cell Biol 1993; 61: 329-337
22. Anderson WF. Human gene therapy. Science 1992; 256: 808-813
23. Walton CM, Wu CH, Wu GY. A DNA delivering system containing listeriolysin O results in enhanced hepatocyte directed gene expression. World J Gastroenterol 1999; 5: 465-469
24. Zhang J, Chen F, Zhong S, Tang K, Shi X, Wang M, Peng J. Anti-HBV effect of targeted antisense RNA against HBV C gene. Zhonghua Ganzangbing Zazhi 2000; 8: 169-170
25. Zhong S, Wen S, Zhang D, Wang Q, Wang S, Ren H. Inhibition of HBV gene expression by antisense oligonucleotides using galactosyted poly(1-lysine)as a hepatotropic carrier. Zhonghua Shiyan He Linchuang Bingduxue Zazhi 2001; 15: 150-153
26. Zhoung S, Wen SM, Zhang DF, Wang QL, Wang SQ, Ren H. Sequencing of PCR amplified HBV DNA pre-c and c regions in the 2.2.15 cells and antiviral action by targeted antisense oligonucleotide directed against sequence. World J Gastroenterol 1998; 4: 434-436
27. Yang CQ, Wang JY, He BM, Liu JJ, Guo JS. Glyco-poly-L-lysine is better than liposomal delivery of exogenous genes to rat of liver. World J Gastroenterol 2000; 6: 526-531
28. Yang CQ, Wang JY, Fang GT, Liu JJ, Guo JS. A comparison between intravenous and peritoneal route on liver targeted uptake and expression of plasmid delivered by Glyco-poly-L-lysine. World J Gastroenterol 2000; 6: 508-512
29. Chen YP, Zhang L, Lu QS, Feng XR, Luo KX. Lactosamination of liposomes and hepatotropic targeting research. World J Gastroenterol 2000; 6: 593-596
30. Yang C, Wang J, Wen S, Liu J, Guo J. Comparative studies of different carriers and introducing routes on the effects of liver targeted uptake of exogenous gene. Zhonghua Ganzangbing Zazhi 2000; 8: 227-229
31. Mani SA, Harish S, Vathsala PG, Rangarajan PN, Padmanaban G. Receptor-mediated gene delivery approach demonstrates the role of 5′-proximal DNA region in conferring phenobarbitone responsiveness to CYP2B2 gene in rat liver in vivo. Biochem Biophys Res Commun 2000; 268: 734-739
32. Biessen EA, Vietsch H, Kuiper J, Bijsterbosch MK, Berkel TJ. Liver uptake of phosphodiester oligodeoxynucleotides is mediated by scavenger receptors. Mol Pharmacol 1998; 53: 262-269
33. Biessen EA, Vietsch H, Rump ET, Fluiter K, Kuiper J, Bijsterbosch MK, Van Berkel TJ. Targeted delivery of oligodeoxynucleotides to parenchymal liver cells in vivo. Biochem J 1999; 340: 783-792
34. Morrey JD, Korba BE, Sidwell RW. Transgenic mice as a chemotherapeutic model for hepatitis B virus infection. Antivir Ther 1998; 3(Suppl 3):59-68
35. Morrey JD, Bailey KW, Korba BE, Sidwell RW. Utilization of transgenic mice replicating high levels of hepatitis B virus for antiviral evaluation of lamivudine. Antiviral Res 1999; 42: 97-108
36. Julander JG, Sidwell RW, Morrey JD. Characterizing antiviral activity of adefovir dipivoxil in transgenic mice expressing hepatitis B virus. Antiviral Res 2002; 55: 27-40