Chlamydophila pneumoniae induces ICAM-1 expression in human aortic endothelial cells via protein kinase C-dependent activation of nuclear factor-κB

Circulation Research

Volumn 92, Issue 10, 2003, Pages 1130-1137

  Vielma, Silvana A ^a   Krings, Gregor ^b   Lopes Virella, Maria F ^c,d  

^a Department of Microbiology ^*  (United States)

^b Grad Prog Molec/Cell Biol/P   (United States)

^c Division of Endocrinology   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Chlamydophila pneumoniae; Intercellular adhesion molecule 1; Mitogen activated protein kinase pathway; Nuclear factor B; Protein kinase C

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BAY 117085; BISINDOLYLMALEIMIDE; CAFFEIC ACID PHENETHYL ESTER; CALPHOSTIN C; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN INHIBITOR; PROTEIN KINASE C; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

AORTA; ARTICLE; ATHEROSCLEROSIS; CHLAMYDOPHILA PNEUMONIAE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; ENZYME PHOSPHORYLATION; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR ENDOTHELIUM;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; AORTA; CAFFEIC ACIDS; CELL MEMBRANE; CELLS, CULTURED; CHLAMYDOPHILA INFECTIONS; CHLAMYDOPHILA PNEUMONIAE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HUMANS; IMMUNOBLOTTING; INTERCELLULAR ADHESION MOLECULE-1; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRILES; PHENYLETHYL ALCOHOL; PROTEIN KINASE C; RNA, MESSENGER; SIGNAL TRANSDUCTION; SULFONES; UP-REGULATION;

EID: 0038727331     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000074001.46892.1C     Document Type: Article

References (41)

1. Casasnovas JM, Stehle T, Liu JH, Wang JH, Springer TA. A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1. Proc Nat Acad Sci U S A. 1998;95:4134-4139.
2. Kevil CG, Patel RP, Bullard DC. Essential role of ICAM-1 in mediating monocyte adhesion to aortic endothelial cells. Am J Physiol Cell Physiol. 2001;281:C1442-C1447.
3. Hubbard AK, Rothlein R. Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades. Free Radic Biol Med. 2000;28:1379-1386.
4. Roebuck KA, Finnegan A. Regulation of intercellular adhesion molecule-1 (CD54) gene expression. J Leukoc Biol. 1999;66:876-888.
5. 2 and tumor necrosis factor-α in endothelial and epithelial cells. J Biol Chem. 1997;272:32910-32918.
6. Khan BV, Parthasarathy SS, Alexander RW, Medford RM. Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells. J Clin Invest. 1995;95:1262-1270.
7. Chen C-C, Chou C-Y, Sun Y-T, Huang W-C. Tumor necrosis factor α-induced activation of downstream NF-κB site of the promoter mediates epithelial ICAM-1 expression and monocyte adhesion: involvement of PKC-α, tyrosine kinase, and IKK2 but not MAPKs, pathway. Cell Signal. 2001;13:543-553.
8. Takei A, Huang Y, Lopes-Virella MF. Expression of adhesion molecules by human endothelial cells exposed to oxidized low density lipoprotein: influences of degree of oxidation and location of oxidized LDL. Atherosclerosis. 2001;154:79-86.
9. Papi A, Johnston SL. Rhinovirus infection induces expression of its own receptor intercellular adhesion molecule 1 (ICAM-1) via increased NF-κB-mediated transcription. J Biol Chem. 1999;274:9707-9720.
10. Krüll M, Klucken AC, Wuppermann FN, Fuhrmann O, Magerl C, Seybold J, Hippenstiel S, Hegemann JH, Jantos CA, Suttorp N. Signal transduction pathways activated in endothelial cells following infection with Chlamydia pneumoniae. J Immunol. 1999;162:4834-4841.
11. Chia MC. The role of adhesion molecules in atherosclerosis. Crit Rev Clin Lab Sci. 1998;35:573-602.
12. Saikku O, Mattila K, Nieminen MS, Makela PH, Huttunen JK, Valtonen V. Serological evidence of an association of a novel chlamydia TWAR with chronic coronary heart disease and acute myocardial infarction. Lancet. 1988;2:983-986.
13. Shor A, Kuo CC, Patton DL. Detection of Chlamydia pneumoniae in coronary arterial fatty streaks and atheromatous plaques. S Afr Med J. 1992;82:158-161.
14. Muhlestein JB. Chronic infection and coronary artery disease. Med Clin North Am. 2000;84:123-148.
15. Campbell LA, Kuo CC, Grayston JT. Chlamydia pneumoniae and cardiovascular disease. Emerg Infect Dis. 1998;4:571-579.
16. Gaydos CA, Summersgill JT, Sahney NN, Ramirez J, Quinn TC. Replication of Chlamydia pneumoniae in vitro in human macrophages, endothelial cells, and aortic artery smooth muscle cells. Infect Immunol. 1996;64:1614-1620.
17. Godzik KL, O'Brien ER, Wang SK, Kuo CC. In vitro susceptibility of human vascular wall cells to infection with Chlamydia pneumoniae. J Clin Microbiol. 1995;33:2411-2414.
18. Bodetti TJ, Timms P. Detection of Chlamydia pneumoniae DNA and antigen in the circulating mononuclear cell fractions of human and koalas. Infect Immunol. 2000;68:2744-2747.
19. Gaydos CA. Growth in vascular cells and cytokine production by Chlamydia pneumoniae. J Infect Dis. 2000;181:S473-S478.
20. Kaukoranta-Tolvanen SSE, Ronni T, Leinonen M, Saikku P, Laitinen K. Expression of adhesion molecules on endothelial cells stimulated by Chlamydia pneumoniae. Microb Pathog. 1996;21:407-411.
21. Molestina RE, Dean D, Miller RD, Ramirez JA, Summersgill JT. Characterization of a strain of Chlamydia pneumoniae isolated from coronary atheroma by analysis of the ompl gene and biological activity in human endothelial cells. Infect Immunol. 1998;66:1370-1376.
22. Molestina RE, Miller RD, Ramirez JA, Summersgill JT. Infection of human endothelial cells with Chlamydia pneumoniae stimulates transendothelial migration of neutrophils and monocytes. Infect Immunol. 1999;67:1323-1330.
23. Dechend R, Maass M, Gieffers J, Dietz R, Scheidereit C, Leutz A, Gulba DC. Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-κB and induces tissue factor and PAI-I expression. Circulation. 1999;100:1369-1373.
24. Vielma S, Gorod AJ, Virella G, Lopes-Virella MF. Chlamydophila pneumoniae infection of human aortic endothelial cells induces the expression of Fc-γ receptor II (FcγRII). Clin Immunol. 2002;104:265-273.
25. Kuo CC, Grayston JT. A sensitive cell line, HL cells, for isolation and propagation of Chlamydia pneumoniae strain TWAR. J Infect Dis. 1990;162:755-758.
26. Wong KH, Skelton S, Chan YK. Efficient culture of Chlamydia pneumoniae with cell lines derived from the human respiratory tract. J Clin Microbiol. 1992;30:1625-1630.
27. Rahman A, Anwar KN, Malik AB. Protein kinase C-ζ mediates TNF-α-induced ICAM-1 gene transcription in endothelial cells. Am J Physiol Cell Physiol. 2000;279:C906-C914.
28. Huang Y, Mironova M, Lopes-Virella MF. Oxidized LDL stimulates matrix metalloproteinase-1 expression in human vascular endothelial cells. Arterioscler Thromb Vasc Biol. 1999;19:2640-2647.
29. Martel-Pelletier J, Mineau F, Jovanovic D, DiBattista JA, Pelletier JP. Mitogen-activated protein kinase and nuclear factor κB together regulate interleukin-17-induced nitric oxide production in human osteoarthritic chondrocytes: possible role of transactivating factor mitogen-activated protein kinase-activated protein kinase (MAPKAPK). Arthritis Rheum. 1999;42:2399-2409.
30. Rahman A, Bando M, Kefer J, Anwar KN, Malik AB. Protein kinase C-activated oxidant generation in endothelial cells signals intercellular adhesion molecule-1 gene transcription. Mol Pharmacol. 1999;55:575-583.
31. Xia P, Gamble JR, Rye KA, Wang L, Hii CST, Cockerill P, Khew-Goodall Y, Bert AG, Barter PJ, Vadas MA. Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway. Proc Nat Acad Sci U S A. 1998;95:14196-14201.
32. 2-terminal kinase is required for intercellular adhesion molecules-1 expression mediated by interleukin-1β: involvement of sequential activation of tyrosine kinase, nuclear factor-κB-inducing kinase, and I κB kinase 2. Mol Pharmacol. 2000;58:1479-1489.
33. De Cesaris P, Starace D, Starace G, Filippini A, Stefanini M, Ziparo E. Activation of Jun N-terminal kinase/stress-activated protein kinase pathway by tumor necrosis factor α leads to intercellular adhesion molecule-1 expression. J Biol Chem. 1999;274:28978-28982.
34. Cominacini L, Pasini AF, Garbin U, Davoli A, Tosetti ML, Campagnola M, Rigoni A, Pastorino AM, Lo Cascio V, Sawamura T. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-κB through an increased production of intracellular reactive oxygen species. J Biol Chem. 2000;275:12633-12638.
35. Pierce JW, Schoenleber R, Jesmok G, Best J, Moore SA, Collins T, Gerritsen ME. Novel inhibitors of cytokine-induced I κB-α phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997;272:21096-21103.
36. Denk A, Goebeler M, Schmid S, Berberich I, Ritz O, Lindemann D, Ludwig S, Wirth T. Activation of NF-κB via the IkB kinase complex is both essential and sufficient for proinflammatory gene expression in primary endothelial cells. J Biol Chem. 2001;276:28451-28458.
37. Morigi M, Angioletti S, Imberti B. Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-κB-dependent fashion. J Clin Invest. 1998;101:1905-1915.
38. Wahl C, Oswald F, Simnacher U, Weiss S, Marre R, Essig A. Survival of Chlamydia pneumoniae-infected Mono Mac 6 cells is dependent on NF-κB binding activity. Infect Immunol. 2001;69:7039-7045.
39. Molestina RE, Miller RD, Lentsch AB, Ramirez JA, Summersgill JT. Requirement for NF-κB in transcriptional activation of monocyte chemotactic protein 1 by Chlamydia pneumoniae in human endothelial cells. Infect Immunol. 2000;68:4282-4288.
40. Ghosh S, Gifford AM, Riviere LR, Tempst P, Nolan GP, Baltimore D. Cloning of the p50 DNA binding subunit of NF-κB: homology to rel and dorsal. Cell. 1990;62:1019-1029.
41. Park CW, Kim JH, Lee H, Kim YS, Ahn HJ, Shin YS, Kim SY, Choi EJ, Chang YS, Bang BK, et al. High glucose-induced intercellular adhesion molecules-1 (ICAM-1) expression through an osmotic effect in rat mesangial cells is PKC-NF-κB-dependent. Diabetologia. 2000;43:1544-1553.