The mutator phenotype theory of carcinogenesis and the complex histopathology of tumours: Support for the theory from the independent occurrence of nuclear abnormality, loss of specialisation and invasiveness among occasional neoplastic lesions

Cellular and Molecular Life Sciences

Volumn 60, Issue 5, 2003, Pages 883-891

  Bignold, L P ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Cancer; Carcinogenesis; Genetic instability; Histopathology; Mutator

Indexed keywords

CARCINOGEN;

ANAPLASTIC CARCINOMA; BOWENOID PAPULOSIS; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL DENSITY; CELL INVASION; CELL NUCLEUS; CELL SPECIFICITY; GENE MUTATION; GENETIC VARIABILITY; HISTOPATHOLOGY; HUMAN; METASTASIS; MICROSATELLITE INSTABILITY; PHENOTYPE; REVIEW; SMALL CELL CARCINOMA; TISSUE STRUCTURE;

EID: 0038715731     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-003-2226-5     Document Type: Review

References (27)

1. Koller P. C. (1957) The genetic component of cancer. In: Cancer, vol. 1, p. 335-403, R. W. Raven (ed.), Butterworth, London
2. Willis R. A. (1948) Pathology of Tumours, Butterworths, London
3. Schwartz N. M. (1965) Genetic instability in Escherichia coli. J. Bacteriol. 89: 712-717
4. Cox E. C. and Yanofsky C. (1967) Altered base ratios in the DNA of an Escherichia coli mutator strain. Proc. Natl Acad. Sci. USA 58: 1895-1902
5. Ono S. (1971) Genetic implication of karyological instability of malignant somatic cells. Physiol. Rev. 51: 496-526
6. Nowell P. C. (1976) The clonal evolution of tumor cell populations. Science 194: 23-8
7. Fidler I. J. (1986) Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis. Cancer Metastasis Rev. 5: 29-49
8. Heppner G. H. and Miller F. R. (1998) The cellular basis of tumour progression. Int. Rev. Cytol. 177: 1-56
9. Stoler D. L., Chen N., Basik M., Kahlenberg M. S., Rodriguez-Bigas M. A., Petrelli N. J. et al. (1999) The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc. Natl Acad. Sci. USA 96: 15121-15126
10. Prehn R. T. (1994) Cancers beget mutations versus mutations beget cancers. Cancer Res. 54: 5296-300.
11. Loeb L. A. (1998) Cancer cells exhibit a mutator phenotype. Adv. Cancer Res. 72: 25-6
12. Bignold L. P. (2002) The mutator phenotype/clonal selection hypothesis can provide a basis for the complex and variable morphological and behavioural features of solid tumour malignancies. Cell Mol. Life Sci. 59: 950-958
13. Bignold L. P. (2002) A hypothesis for the influence of fixatives on the chromatin patterns of interphase nuclei based on shrinkage and retraction of nuclear and perinuclear structures. Br. J. Biomed. Sci. 59: 105-113
14. Martinez N., Alonso A., Moragues M. D., Ponton J. and Schneider J. (1999) The nuclear pore complex protein Nu88 is over-expressed in tumor cells. Cancer Res. 59: 5408-5411
15. Sell S. (1993) Cellular origin of cancer: dedifferentiation or stem cell maturation arrest? Environ. Health Perspect. 101: (Suppl. 5): 15-26
16. Shields P. G. and Harris C. C. (1993) Principles of carcinogenesis: chemical. In: Cancer, Principles and Practice of Oncology, 4th edn, chapt. 11, pp. 200-212, DeVita Jr, V. T., Hellman S., and Rosenberg S. A. (eds), Lippincott-Raven, Philadelphia
17. Sell S., Becker F. F., Leffert H. L. and Watabe L. (1976) Expression of an oncodevelopmental gene product (alpha-fetoprotein) during fetal development and adult oncogenesis. Cancer Res. 36: 4239-4249
18. Shih I. M., Wang T. L., Traverso G., Romans K., Hamilton S. R., Ben-Sasson S. et al. (2001) Top-down morphogenesis of colorectal tumors. Proc. Natl Acad. Sci. USA 98: 2640-2645
19. Alison M. R., Poulsom R., Forbes S. and Wright N. A. (2002) An introduction to stem cells. J. Pathol. 197: 419-423
20. Hittelman W. N. (2001) Genetic instability in epithelial tissues at risk of cancer. Ann. N. Y. Acad. Sci. 952: 1-12
21. Colby T. V., Koss M. N. and Travis W. D. (1995) Tumors of the lower respiratory tract. In: Atlas of Tumor Pathology, 3rd series, fascicle 13, p. 533, Armed Forces Institute of Pathology, Washington DC
22. Rosai J., Carcangui M. L. and Delellis R. A. (1992) Tumours of the Thyroid Gland, p. 61. Armed Forces Institute of Pathology, Washington DC
23. Yuspa S. H. and Shields P. G. (1997) Etiology of cancer. In: Cancer, Principles and Practice of Oncology, 5th edn, chapt. 9, pp. 185-202, DeVita V. T. Jr, Hellman S. and Rosenberg S. A. (eds), Lippincott-Raven, Philadelphia
24. Cooper D. P., O'Connor P. J., Povey A. C. and Rafferty J. A. (1995) Cell and molecular mechansims in chemical carcinogenesis. In: Oxford Textbook of Oncology, pp. 135-147, Peckham M., Pinedo H. and Veronesi U. (eds), Oxford University Press, Oxford
25. Reich D. E., Schaffner S. F., Daly M. J., McVean G., Mullikin J. C., Higgins J. M. et al. (2002) Human genome sequence variation and the influence of gene history, mutation and recombination. Nat. Genet. Aug. 5 (epub ahead of print)
26. Rabbitts T. H. (2001) Chromosomal translocation master genes, mouse models and experimental therapeutics. Oncogene 20: 5763-77
27. Lasky T. and Silbergeld E. (1996) P53 mutations associated with breast, colorectal, liver, lung and ovarian cancers. Environ. Health Perspect. 104: 1324-31.