Codon 201 polymorphism of DCC gene is a prognostic factor in patients with colorectal cancer

Cancer Detection and Prevention

Volumn 27, Issue 3, 2003, Pages 216-221

  Zhang, Hong ^a   Arbman, Gunnar ^b   Sun, Xiao Feng ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b VRINNEVI HOSPITAL   (Sweden)

Author keywords

Codon 201 polymorphism; Colorectal cancer; DCC gene; PCR RFLP; Prognosis

Indexed keywords

EID: 0038715721     PISSN: 0361090X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-090X(03)00064-3     Document Type: Article

References (17)

1. Reale MA, Hu G, Zafar AI, Getzenberg RH, Levine SM, Fearon ER. Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues. Cancer Res 1994;54:4493-501.
2. Fearon ER. DCC:DCC: is there a connection between tumorigenesis and cell guidance molecules? Biochim Biophys Acta 1996;9(1288):M17-23.
3. Shibata D, Reale MA, Lavin P, et al. The DCC protein and prognosis in colorectal cancer. New Engl J Med 1996;335:1727-32.
4. Sun X-F, Rütten S, Zhang H, Nordenskjöld B. Expression of the deleted in colorectal cancer gene is related to prognosis in DNA diploid and low proliferative colorectal adenocarcinoma. J Clin Oncol 1999;17:1745-50.
5. Carethers JM, Hawn MT, Greenson JK, Hitchcock CL, Boland CR. Prognostic significance of allelic lost at chromosome 18q21 for stage II colorectal cancer. Gastroenterology 1998;114:1188-95.
6. Iacopetta B, DiGrandi S, Dix B, Haig C, Soong R, House A. Loss of heterozygosity of tumour suppressor gene loci in human colorectal carcinoma. Eur J Cancer 1994;30A:664-70.
7. Miyake S, Nagai K, Yoshino K, Oto M, Endo M, Yuasa Y. Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis. Cancer Res 1994;54:3007-10.
8. Arg/Gly polymorphism of DCC (deleted in colorectal carcinoma) gene in flat- and polypoid-type colorectal tumors. Digest Dis Sci 1997;42:2446-52.
9. Schmitt CA, Thaler KR, Wittig BM, Kaulen H, Büschenfelde CKMZ, Dippold WG. Detection of the DCC gene product in normal and malignant colorectal tissues and its related to a codon 201 mutation. Br J Cancer 1998;77:588-94.
10. Zhang H, Nordenskjöld B, Dufmats M, Söderquist P, Sun X-F. K-ras muttions in colorectal adenocarcinoma and neighbouring transitional mucosa. Eur J Cancer 1998;34:2053-7.
11. Cho KR, Fearon ER. DCC: linking tumour suppressor genes and altered cell surfaceinteractions in cancer? Eur J Cancer 1995;31A:1055-60.
12. Hedrick L, Cho KR, Fearon ER, Wu TC, Kinzler KW, Vogelstein B. The DCC gene product in cellular differentiation and colorectal tumorigenesis. Genes Dev 1994;15:1174-83.
13. Hohne MW, Halatsch ME, Kahl GF, Weinel RJ. Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma. Cancer Res 1992;52:2616-9.
14. Edelman G. Morphoregulatory molecules. Biochemistry 1988;27:3533-43.
15. Zhang H, Sofia E, Sun X-F. Cliniopathological and genetic characteristics of mucinous carcinomas in the colorectum. Int J Oncol 1999;14:1057-61.
16. Kong XT, Choi SH, Bessho F, et al. Codon 201(Gly) polymorphic type of the DCC gene is related to disseminated neuroblastoma. Neoplasia 2001;3:267-72.
17. Jernvall P, Makinen MJ, Karttunen TJ, Makela J, Vihko P. Loss of heterozygosity at 18q21 is indicative of recurrence and therefore poor prognosis in a subset of colorectal cancers. Br J Cancer 1999;79:903-8.