Simultaneous enantiospecific separation and quantitation of mephenytoin and its metabolites nirvanol and 4′-hydroxymephenytoin in human plasma by liquid chromatography

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 791, Issue 1-2, 2003, Pages 179-191

  Jansson, Britt ^a   Simonsson, Ulrika S H ^a   Ashton, Michael ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

4 Hydroxymephenytoin; Mephenytoin; Nirvanol

Indexed keywords

DRUG PRODUCTS; ENZYMES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PLASMAS; SEPARATION;

POLYMORPHISMS;

METABOLITES;

4' HYDROXYMEPHENYTOIN; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; DRUG METABOLITE; ENZYME; MEPHENYTOIN; NORMEPHENYTOIN; OMEPRAZOLE; OMEPRAZOLE DERIVATIVE; OROSOMUCOID;

ARTICLE; CHIRALITY; DRUG DETERMINATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME POLYMORPHISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; METABOLIC CAPACITY; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

EID: 0038697831     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1570-0232(03)00221-6     Document Type: Article

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