Significant and persistent loss of bone mineral density in the femoral neck after haematopoietic stem cell transplantation: Long-term follow-up of a prospective study

British Journal of Haematology

Volumn 121, Issue 3, 2003, Pages 462-468

  Gandhi, Maher K ^a   Lekamwasam, Sarath ^a   Inman, Ingrid ^a   Kaptoge, Stephen ^a   Sizer, Lorraine ^a   Love, Shirley ^b   Bearcroft, Philip W ^a   Milligan, Thomas P ^c   Price, Christopher P ^d   Marcus, Robert E ^a   Compston, Juliet E ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c ROYAL LONDON HOSPITAL   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Allogeneic; Autologous; Bone mineral density; Femoral neck; Haematopoietic stem cell transplantation

Indexed keywords

ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; BUSULFAN; CARMUSTINE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; ETOPOSIDE; IMMUNOSUPPRESSIVE AGENT; MELPHALAN; METHOTREXATE; PARATHYROID HORMONE; THIOTEPA;

ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE DENSITY; BONE MINERAL; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HODGKIN DISEASE; HUMAN; LEUKEMIA; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; NONHODGKIN LYMPHOMA; OSSIFICATION; OSTEOPOROSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; SPINE RADIOGRAPHY; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME; VERTEBRA FRACTURE;

ADULT; BONE DENSITY; BONE MARROW TRANSPLANTATION; FEMALE; FEMUR NECK; FOLLOW-UP STUDIES; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; MIDDLE AGED; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PROSPECTIVE STUDIES; SPINE; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0038692338     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04303.x     Document Type: Article

References (35)

1. Banfi, A., Podesta, M., Fazzuoli, L., Sertoli, M.R., Venturini, M., Santini, G., Cancedda, R. & Quarto, R. (2001) High-dose chemotherapy shows a dose-dependent toxicity to bone marrow osteoprogenitors: a mechanism for post-bone marrow transplantation osteopenia. Cancer, 92, 2419-2428.
2. Bishop, N.J., Ninkovic, M., Alexander, G.J., Holmes, S.D., Milligan, T., Price, C. & Compston, J.E. (1999) Changes in calcium homeostasis in patients undergoing liver transplantation: effects of a single infusion of pamidronate administered pre-operatively. Clinical Science. 97, 157-163.
3. Bone, H.G., Greenspan, S.L., McKeever, C., Bell, N., Davidson, M., Downs, R.W., Emkey, R., Meunier, P.J., Miller, S.S., Mulloy, A.L., Recker, R.R., Weiss, S.R., Heyden, N., Musliner, T., Suryawanshi, S., Yates, A.J. & Lombardi, A. (2000) Alendronate and estrogen effects in postmenopausal women with low bone mineral density. Alendronate/Estrogen Study Group. Journal of Clinical Endocrinology and Metabolism, 85, 720-726.
4. Carlson, K., Simonsson, B. & Ljunghall, S. (1994) Acute effects of high-dose chemotherapy followed by bone marrow transplantation on serum markers of bone metabolism. Calcified Tissue International, 55, 408-411.
5. Compston, J. (2000) Prevention and treatment of osteoporosis. Clinical guidelines and new evidence. Journal of the Royal College of Physicians of London, 34, 518-521.
6. Ebeling, P.R., Thomas, D.M., Erbas, B., Hopper, J.L., Szer, J. & Grigg, A.P. (1999) Mechanisms of bone loss following allogeneic and autologous hemopoietic stem cell transplantation. Journal of Bone and Mineral Research, 14, 342-350.
7. Ensrud, K.E., Black, D.M., Palermo, L., Bauer, D.C., Barrett-Connor E., Quandt, S.A., Thompson, D.E. & Karpf, D.B. (1997) Treatment with alendronate prevents fractures in women at highest risk: results from the Fracture Intervention Trial. Archives of Internal Medicine, 157, 2617-2624.
8. Gandhi, M.K., Jestice, K., Scott, M.A., Bloxham, D., Bass, G. & Marcus, R.E. (1999a) The minimum CD34 threshold depends on prior chemotherapy in autologous peripheral blood stem cell recipients. Bone Marrow Transplantation, 23, 9-13.
9. Gandhi, M., Jestice, H., Scott, M., Bloxham, D., Bass, G., Craig, J. & Marcus, R. (1999b) A comparison of CD34+ cell selected and unselected autologous peripheral blood stem cell transplantation for multiple myeloma: a case controlled analysis. Bone Marrow Transplantation, 24, 369-375.
10. Gandhi, M.K., Egner, W., Sizer, L., Inman, I., Zambon, M., Craig, J.I. & Marcus, R.E. (2001) Antibody responses to vaccinations given within the first two years after transplant are similar between autologous peripheral blood stem cell and bone marrow transplant recipients. Bone Marrow Transplantation, 28, 775-781.
11. Hamanishi, C., Yoshii, T., Totani, Y. & Tanaka, S. (1994) Bone mineral density of lengthened rabbit tibia is enhanced by transplantation of fresh autologous bone marrow cells. An experimental study using dual X-ray absorptiometry. Clinical Orthopedics, 303, 250-255.
12. Harris, S.T., Watts, N.B., Genant, H.K., McKeever, C.D., Hangartner, T., Keller, M., Chesnut, III, C.H. Brown, J. Eriksen, E.F. Hoseyni, M.S. Axelrod, D.W. & Miller, P.D. (1999) Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. Journal of the American Medical Association, 282, 1344-1352.
13. Henderson, N.K. Sambrook, P.N. Kelly, P.J. Macdonald, P. Keogh, A.M. Spratt, P. & Eisman, J.A. (1995) Bone mineral loss and recovery after cardiac transplantation. Lancet, 346, 905.
14. Hussaini, S.H. Oldroyd, B. Stewart, S.P. Roman, F. Smith, M.A. Pollard, S. Lodge, P. O'Grady, J.G. & Losowsky, M.S. (1999) Regional bone mineral density after orthotopic liver transplantation. European Journal of Gastroenterology and Hepatology, 11, 157-163.
15. Kang, M.I. Lee, W.Y. Oh, K.W. Han, J.H. Song, K.H. Cha, B.Y. Lee, K.W. Son, H.Y. Kang, S.K. & Kim, C.C. (2000) The short-term changes of bone mineral metabolism following bone marrow transplantation. Bone, 26, 275-279.
16. Katz, I.A. & Epstein, S. (1992) Post-transplantation bone disease. Journal of Bone and Mineral Research, 7, 123-126.
17. Keilholz, U. Max, R. Scheibenbogen, C. Wuster, C. Korbling, M. & Haas, R. (1997) Endocrine function and bone metabolism 5 years after autologous bone marrow/blood-derived progenitor cell transplantation. Cancer, 79, 1617-1622.
18. Keogh, J.B. Tsalamandris, C. Sewell, R.B. Jones, R.M. Angus, P.W. Nyulasi, I.B. & Seeman, E. (1999) Bone loss at the proximal femur and reduced lean bone mass following liver transplantation: a longitudinal study. Nutrition, 15, 661-664.
19. Kreig, M.A. Seydoux, C. Sandini, L. Goy, J.J. Berguer, D.G. Thiebaud, D. & Burckhardt, P. (2001) Intravenous pamidronate as treatment for osteoporosis after heart transplantation: a prospective study. Osteoporosis International, 12, 112-116.
20. Laan, R.F. van Riel, P.L. van de Putte, L.B. van Erning, L.J. van't Hof, M.A. & Lemmens, J.A. (1993) Low-dose prednisone induces rapid reversible axial bone loss in patients with rheumatoid arthritis. A randomized, controlled study. Annals of Internal Medicine, 119, 963-968.
21. Liberman, U.A. Weiss, S.R. Broil, J. Minne, H.W. Quan, H. Bell, N.H. Rodriguez-Portales, J. Downs, Jr. R.W., Dequeker, J. & Favus, M. (1995) Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group. New England Journal of Medicine, 333, 1437-1443.
22. Ninkovic, M., Skingle, S.J., Bearcroft, P.W., Bishop, N., Alexander, G.J. & Compston, J.E. (2000) Incidence of vertebral fractures in the first three months after orthotopic liver transplantation. European Journal of Gastroenterology and Hepatology, 12, 931-935.
23. Ninkovic, M., Love, S., Tom, B.D., Bearcroft, P.W., Alexander, G.J. & Compston, J.E. (2002) Lack of effect of intravenous pamidronate on fracture incidence and bone mineral density after orthotopic liver transplantation. Journal of Hepatology, 37, 93-100.
24. Orwoll, E., Ettinger, M., Weiss, S., Miller, P., Kendler, D., Graham, J., Adami, S., Weber, K., Lorenc, R., Pietschmann, P., Vandormael, K. & Lombardi, A. (2000) Alendronate for the treatment of osteoporosis in men. New England Journal of Medicine, 343, 604-610.
25. Pols, H.A., Felsenberg, D., Hanley, D.A., Stepan, J., Munoz-Torres, M., Wilkin, T.J., Qin-sheng, G., Galich, A.M., Vandormael, K., Yates, A.J. & Stych, B. (1999) Multinational, placebo-controlled, randomized trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: results of the FOSIT study. Fosamax International Trial Study Group. Osteoporosis International, 9, 461-468.
26. Schimmer, A.D., Quatermain, M., Imrie, K., Ali, V., McCrae, J., Stewart, A.K., Crump, M., Derzko, C. & Keating, A. (1998) Ovarian function after autologous bone marrow transplantation. Journal of Clinical Oncology, 16, 2359-2363.
27. Schimmer, A.D., Mah, K., Bordeleau, L., Cheung, A., Ali, V., Falconer, M., Trus, M. & Keating, A. (2001) Decreased bone mineral density is common after autologous blood or marrow transplantation. Bone Marrow Transplantation, 28, 387-391.
28. Schulte, C., Beelen, D.W., Schaefer, U.W. & Mann, K. (2000) Bone loss in long-term survivors after transplantation of hematopoietic stem cells: a prospective study. Osteoporosis International, 11, 344-353.
29. Scott, M.A., Gandhi, M.K., Jestice, H.K., Mahendra, P., Bass, G. & Marcus, R.E. (1998) A trend towards an increased incidence of chronic graft-versus-host disease following allogeneic peripheral blood progenitor cell transplantation: a case controlled study. Bone Marrow Transplantation, 22, 273-276.
30. Siddiqi, A., Burrin, J.M., Noonan, K., James, I., Wood, D.F., Price, C.P. & Monson, J.P. (1997) A longitudinal study of markers of bone turnover in Graves' disease and their value in predicting bone mineral density. Journal of Clinical Endocrinology and Metabolism, 82, 753-759.
31. Stern, J.M., Chesnut, III, C.H., Bruemmer, B., Sullivan, K.M., Lenssen, P.S., Aker, S.N. & Sanders, J. (1996) Bone density loss during treatment of chronic GVHD. Bone Marrow Transplantation, 17, 395-400.
32. Vedi, S., Ninkovic, M., Garrahan, N.J., Alexander, G.J. & Compston, J.E. (2002) Effects of a single infusion of pamidronate prior to liver transplantation: a bone histomorphometric study. Transplant International, 15, 290-295.
33. Weilbaecher, K.N. (2000) Mechanisms of osteoporosis after hematopoietic cell transplantation. Biology of Blood and Marrow Transplantation, 6, 165-174.
34. Weinstein, R.S., Jilka, R.L., Parfitt, A.M. & Manolagas, S.C. (1998) Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. Journal of Clinical Investigation, 102, 274-282.
35. Withold, W., Wolf, H.H., Kollbach, S., Heyll, A., Schneider, W. & Reinauer, H. (1996) Relationship between bone metabolism and plasma cytokine levels in patients at risk of post-transplantation bone disease after bone marrow transplantation. European Journal of Clinical Chemistry and Clinical Biochemistry, 34, 295-299.