Effects of hypothyroidism and withholding of feed on plasma lipid concentrations, concentration and composition of very-low-density lipoprotein, and plasma lipase activity in horses

American Journal of Veterinary Research

Volumn 64, Issue 7, 2003, Pages 823-828

  Frank, Nicholas ^a,c   Sojka, Janice E ^a   Latour, Mickey A ^b  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; FATTY ACID; LIPID; LIPOPROTEIN LIPASE; LIVER TRIACYLGLYCEROL LIPASE; THYROID HORMONE; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL FOOD; ARTICLE; BLOOD SAMPLING; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET RESTRICTION; ENZYME ACTIVITY; EUTHYROIDISM; FATTY ACID BLOOD LEVEL; FEMALE; HORSE; HYPOTHYROIDISM; LIPID BLOOD LEVEL; LIPID COMPOSITION; NONHUMAN; REACTION TIME; TRIACYLGLYCEROL BLOOD LEVEL; TRIACYLGLYCEROL LIPASE BLOOD LEVEL;

ANIMALS; CHOLESTEROL; FATTY ACIDS, NONESTERIFIED; FEMALE; FOOD DEPRIVATION; HORSES; HYPOTHYROIDISM; LIPASE; LIPIDS; LIPOPROTEINS, VLDL; TRIGLYCERIDES;

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

EID: 0038691854     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2003.64.823     Document Type: Article

References (40)

1. Naylor JM, Kronfeld DS, Acland H. Hyperlipemia in horses: effects of undernutrition and disease. Am J Vet Res 1980;41:899-905.
2. Rose RJ, Sampson D. Changes in certain metabolic parameters in horses associated with food deprivation and endurance exercise. Res Vet Sci 1982;32:198-202.
3. Frank N, Sojka JE, Latour MA. Effect of withholding feed on concentration and composition of plasma very low density lipoprotein and serum nonesterified fatty acids in horses. Am J Vet Res 2002;63:1018-1021.
4. Baetz AL, Pearson JE. Blood constituent changes in fasted ponies. Am J Vet Res 1972;33:1941-1946.
5. Morris MD, Zilversmit DB, Hintz HF. Hyperlipoproteinemia in fasting ponies. J Lipid Res 1972;13:383-389.
6. Bauer JE. Plasma lipids and lipoproteins of fasted ponies. Am J Vet Res 1983;44:379-384.
7. Freestone JF, Wolfsheimer KJ, Ford RB, et al. Triglyceride, insulin, and cortisol responses of ponies to fasting and dexamethasone administration. J Vet Intern Med 1991;5:15-22.
8. Forhead AJ, Smart D, Smith RF, et al. Transport-induced stress responses in fed and fasted donkeys. Res Vet Sci 1995;58:144-151.
9. Watson T. Equine hyperlipaemia. In: Watson T, ed. Metabolic and endocrine problems of the horse. Philadelphia: WB Saunders Co, 1998;23-40.
10. Watson TDG, Burns L, Love S, et al. Plasma lipids, lipoproteins and post-heparin lipases in ponies with hyperlipaemia. Equine Vet J 1992;24:341-346.
11. Frank N, Sojka JE, Latour MA, et al. Effect of hypothyroidism on blood lipid concentrations in horses. Am J Vet Res 1999; 60:730-733.
12. Henneke DR, Potter GD, Kreider JL. Relationship between condition score, physical measurements and body fat percentage in mares. Equine Vet J 1983;15:371-372.
13. Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
14. Markwell MK, Haas SM, Bieber LL, et al. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein. Anal Biochem 1978;87:206-210.
15. Watson TDG, Burns L, Packard CJ, et al. Selective measurement of lipoprotein lipase and hepatic triglyceride lipase in heparinized plasma from horses. Am J Vet Res 1992;53:771-775.
16. Belfrage P, Vaughan M. Simple liquid-liquid partition system for isolation of labeled oleic acid from mixtures with glycerides. J Lipid Res 1969;10:341-344.
17. Duren SE, Jackson SG, Baker JP et al. Effect of dietary fat on blood parameters in exercised Thoroughbred horses. In: Gillespie JR, Robinson NE, eds. Equine exercise physiology 2. Davis, Calif: ICEEP Publications, 1987;674-685.
18. Geelen SNJ, Jansen WL, Geelen MJH. Lipid metabolism in equines fed a fat-rich diet. Int J Vitam Nutr Res 2000;70:148-152.
19. Geelen SNJ, Sloet van Oldruitenborgh-Oosterbaan MM, Beynen AC. Dietary fat supplementation and equine plasma lipid metabolism. Equine Vet J Suppl 1999;30:475-478.
20. Geelen SNJ, Jansen WL, Sloet van Oldruitenborgh-Oosterbaan MM, et al. Fat feeding increases equine heparin-released lipoprotein lipase activity. J Vet Intern Med 2001;15:478-481.
21. Orme CE, Harris RC, Marlin DJ, et al. Metabolic adaptations to a fat supplemented diet by the Thoroughbred horse. Br J Nutr 1997;78:443-458.
22. Schmidt O, Deegen E, Fuhrmann H, et al. Effects of fat Feeding and energy level on plasma metabolites and hormones in Shetland poines. J Vet Med A Physiol Pathol Clin Med 2001;48:39-49.
23. Messer NT, Johnson PJ, Refsal KR, et al. Effect of food deprivation on baseline iodothyronine and cortisol concentrations in healthy, adult horses. Am J Vet Res 1995;56:116-121.
24. Ganong WF. Review of medical physiology. 18th ed. Stamford, Conn: Appleton & Lange, 1999;303-317.
25. Watson TDG, Burns L, Love S, et al. The isolation, characterization and quantification of the equine plasma lipoproteins. Equine Vet J 1991;23:353-359.
26. Fainaru M, Schafer Z. Effect of prolonged fasting on plasma lipids, lipoproteins and apolipoprotein B in 12 physicians participating in a hunger strike: an observational study. Isr Med Assoc J 2000;2:215-219.
27. Stachel CS, Weik HO. In vitro catabolism of very low density lipoproteins from the horse (Equus caballus) by the action of autologous lipoprotein lipase. Comp Biochem Physiol 1995;112B:137-146.
28. Kalderon B, Mayorek N, Berry E. Fatty acid cycling in the fasting rat. Am J Physiol Endocrinol Metab 2000;279:E221-E227.
29. Jensen M, Ekberg K, Landau BR. Lipid metabolism during fasting. Am J Physiol Endocrinol Metab 2001;281:E789-E793.
30. Orme CE, Harris RC. A comparison of the lipolytic and anticoagulative properties of heparin and pentosan polysulphate in the thoroughbred horse. Acta Physiol Scand 1997;159:179-185.
31. van Beek AP, van Barlingen HH, de Ruijter-Heijstek FC, et al. Preferential clearance of apoB-48-containing lipoproteins after heparin-induced lipolysis is modulated by lipoprotein lipase activity. J Lipid Res 1998;39:322-332.
32. Watson TDG, Burns L, Packard CJ, et al. Effects of pregnancy and lactation on plasma lipid and lipoprotein concentrations, lipoprotein composition and post-heparin lipase activities in Shetland pony mares. J Reprod Fertil 1993;97:563-568.
33. Yamamoto M, Yamamoto I, Tanaka Y, et al. Purification of horse (Equus caballus) serum lecithin: cholesterol acyltransferase. Comp Biochem Physiol 1987;88B:363-368.
34. Watson TDG, Packard CJ, Shepherd J. Plasma lipid transport in the horse (Equus caballus). Comp Biochem Physiol 1993;106B:27-34.
35. Germack R, Starzec A, Perret GY. Regulation of beta 1- and beta 3-adrenergic agonist-stimulated lipolytic response in hyperthyroid and hypothyroid rat white adipocytes. Br J Pharmacol 2000; 129:448-450.
36. Beylot M, Martin C, Laville M. Lipolytic and ketogenic fluxes in human hyperthyroidism. J Clin Endocrinol Metab 1991;73:42-49.
37. Breidenbach A, Fuhrmann H, Deegen E, et al. Studies on equine lipid metabolism 2. Lipolytic activities of plasma and tissue lipases in large horses and ponies. Zentralbl Veterinarmed A 1999;46:39-48.
38. Grundy SM, Vega GL, Otvos JD, et al. Hepatic lipase activity influences high density lipoprotein subclass distribution in normotriglyceridemic men: genetic and pharmacological evidence. J Lipid Res 1999;40:229-234.
39. Qiu S, Bergeron N, Kotite L, et al. Metabolism of lipoproteins containing apolipoprotein B in hepatic lipase-deficient mice. J Lipid Res 1998;39:1661-1668.
40. Kihara S, Wolle J, Ehnholm C, et al. Regulation of hepatic triglyceride lipase by thyroid hormone in HepG2 cells. J Lipid Res 1993;34:961-970.