Regulation of β1- and β3-adrenergic agonist-stimulated lipolytic response in hyperthyroid and hypothyroid rat white adipocytes

British Journal of Pharmacology

Volumn 129, Issue 3, 2000, Pages 448-456

  Germack, Renée ^a   Starzec, Anna ^a,b   Perret, Gérard Y ^a  

^a UNIVERSITÉ PARIS 13   (France)

^b Inst d'Oncol Cell et Molec Hum   (France)

Author keywords

Adipocytes; BRL 37344; CGP 12177; Hyperthyroidism; Hypothyroidism; Lipolyse; Xamoterol

Indexed keywords

4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; ADENYLATE CYCLASE; BETA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; BUCLADESINE; CYCLIC AMP; ENPROFYLLINE; FORSKOLIN; GLYCEROL; ISOPRENALINE; LIOTHYRONINE; MESSENGER RNA; NORADRENALIN; PHOSPHODIESTERASE; XAMOTEROL;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; HYPERTHYROIDISM; HYPOTHYROIDISM; LIPOLYSIS; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SIGNAL TRANSDUCTION; THYROID FUNCTION; THYROIDECTOMY;

ADENYLATE CYCLASE; ADIPOSE TISSUE; ADRENERGIC BETA-AGONISTS; ANIMALS; BLOTTING, NORTHERN; CELL MEMBRANE; FORSKOLIN; HYPERTHYROIDISM; HYPOTHYROIDISM; KINETICS; LIPOLYSIS; MALE; PROPANOLAMINES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-3; RNA, MESSENGER; THYROIDECTOMY;

EID: 0033970476     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703008     Document Type: Article

References (34)

1. Adli, H., Bazin, R., Vassy, R. & Perret, G.Y. (1997). Effects of triiodothyronine administration on the adenyl cyclase system in brown adipose tissue of rat. Am. J. Physiol., 273, E247-E253.
2. 3-adrenergic receptor agonists in obese mice. Am. J. Physiol., 268, E680-E684.
3. 1-adrenergic receptor gene in cultured ventricular myocytes. J. Biol. Chem., 266, 15863-15869.
4. 3-adrenergic activation of adenyl cyclase in mouse white adipocytes: modulation by GTP and effect of obesity. J. Cell. Biochem., 58, 464-473.
5. Ben Cheikh, R., Chomard, P., Dumas, P. & Autissier, N. (1994). Influence of prolonged fasting on thyroid hormone modulation of lipolysis in isolated epididymal adipocytes of Wistar rats. Eur. J. Endocrinol., 131, 516-521.
6. Bouyard, P. & Jadot, G. (1977). Thyroïdectomie totale chez le rat. J. Pharmacol., 8, 219.
7. i in rat adipocytes. Cell. Signal., 6, 457-465.
8. 1-adrenergic receptors in adipose tissue of congenitally obese (C57BL/6J ob/ob) mice. Mol. Endocrinol., 8, 518-527.
9. Danielson, P.E., Forss-Petter, S., Brow, M.A., Calavetta, L., Douglass, J., Milner, R.J. & Sutcliffe, J.G. (1988). P1B15: cDNA clone of the rat mRNA encoding cyclophilin. DNA, 7, 261-267.
10. Degerman, E., Belfrage, P. & Manganiello, V.C. (1997). Structure, localization, and regulation of cGMP-inhibited phosphodiesterace (PDE3). J. Biol. Chem., 272, 6823-6826.
11. 3-adrenoceptor expression in 3T3-F442A differentiating adipocytes. Eur. J. Biochem., 239, 519-525.
12. Elks, M.M. & Manganiello, V.C. (1985). Effects of thyroid hormone on regulation of lipolysis and adenosinc 3′,5′-monophosphate metabolism in 3T3-LI adipocytes. Endocrinology, 117, 947-953.
13. 4-adrenoceptor. Br. J. Pharmacol., 122, 1244-1250.
14. 3-adrenergic agonist BRL 37344 in rat white adipocytes. Fundam. Clin. Pharmacol., 10, 289-297.
15. Germack, R., Starzec, A.B., Vassy, R. & Perret, G.Y. (1997). β-adrenoceptor subtype expression and function in rat white adipocytes. Br. J. Pharmacol., 120, 201-210.
16. Gettys, T.W., Rohlfs, E.M., Prpic, V., Daniel, K.W., Taylor, I.L. & Collins, S. (1995). Age-dependent changes in β-adrenergic receptor subtypes and adenylyl cyclase activation in adipocytes from Fischer 344 rats. Endocrinology, 136, 2022-2032.
17. Kent, R.S., De Lean, A. & Lefkowitz, R.J. (1980). A quantitative analysis β-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modelling of ligand binding data. Mol. Pharmacol., 17, 14-23.
18. Malbon, C.C., Moreno, F.J., Cabelli, R.J. & Fain, J.N. (1978). Flat cell adenylate cyclase and β-adrenergic receptors in altered thyroid states. J. Biol. Chem., 253, 671-678.
19. Malbon, C.C., Rapiejko, P.J. & Watkins, D.C. (1988). Permissive hormone regulation of hormone-sensitive effector systems. TIPS, 9, 33-36.
20. 1-adrenergic receptor gene. J. Biol. Chem., 265, 12960-12965.
21. i3α in adipocytes of hypothyroid rats. Biochem. J., 270, 765-769.
22. Mills, I., Garcia-Sainz, J.A. & Fain, J.N. (1986). Pertussis effects on adenylate cyclase activity, cyclic AMP accumulation and lipolysis in adipocytes from hypothyroid, euthyroid and hyperthyroid rats. Biochim. Biophy. Acta., 879, 619-630.
23. Munson, P.J. & Rodbard, D. (1980). Ligand: a versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem., 107, 220-239.
24. 3-adrenoceptor-induced activation of cyclic AMP-dependent protein kinase with activation of lipolysis in rat white adipocytes. Biochem. Pharmacol., 46, 575-581.
25. 3-adrenergic receptor: relationship with atypical receptor of adipocytes. EMBO J., 10, 3721-3727.
26. Rapiejko, P.J. & Malbon, C.C. (1987). Short-term hyperthyroidism modulates adenosine receptors and catalytic activity of adenylate cyclase in adipocytes. Biochem. J., 241, 765-774.
27. Rapiejko, P.J., Watkins, D.C., Ros, M. & Malbon, C.C. (1989). Thyroid hormones regulate G-protein β-subunit mRNA expression in vivo. J. Biol. Chem., 264, 16183-16189.
28. 2-adrenergic receptor mRNA levels in brown adipose tissue and heart of hypothyroid rats. Biochem. J., 277, 625-629.
29. Rodbell, M. (1964). Metabolism of isolated fat cells. J. Biol. Chem., 239, 375-380.
30. Ros, M., Northup, J.K. & Malbon, C.C. (1988). Steady-state levels of G-proteins and β-adrenergic receptors in rat fat cells. J. Biol. Chem., 263, 4362-4368.
31. 3-adrenergic receptors in brown and white adipose tissue. Endocrinology, 136, 3277-3284.
32. Ukena, D., Schudt, C. & Sybrecht, G.W. (1993). Adenosine receptor-blocking xanthines as inhibitors of phosphodiesterase isozymes. Biochem. Pharmacol., 45, 847-851.
33. Van Inwegen, R.G., Robison, G.A. & Thomson, W.J. (1975). Cyclic nucleotide phosphodiesterases and thyroid hormones. J. Biol. Chem., 250, 2452-2456.
34. Van Liefde, I., Van Witzanburg, A. & Vauquelin, G. (1992). Multiple beta adrenergic receptor subclasses mediate the l-isoproterenol-induced lipolytic response in rat adipocytes. J. Pharmacol. Exp. Ther., 262, 552-558.