Synthesis and enzymatic transformations of 5-halo-6-methoxy-5,6-dihydro derivatives of 5-[1-methoxy-2-halo(or 2,2-dihalo)ethyl]-2′-deoxyuridines as potential herpes simplex virus inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 18, Issue 3, 2003, Pages 273-278

  Kumar, Rakesh ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

5,6 Dihydro derivatives; 5 Substituted 2 deoxyuridines; Drug design; Inhibitors; Pyrimidine nucleosides

Indexed keywords

5 BROMO 5 (1 METHOXY 2 BROMOETHYL) 6 METHOXY 5,6 DIHYDRO 2' DEOXYURIDINE; 5 BROMO 5 (1 METHOXY 2 IODOETHYL) 6 METHOXY 5,6 DIHYDRO 2' DEOXYURIDINE; 5 BROMO 5 (1 METHOXY 2,2 DIBROMOETHYL) 6 METHOXY 5,6 DIHYDRO 2' DEOXYURIDINE; 5 CHLORO 5 (1 METHOXY 2 BROMOCHLOROETHYL) 6 METHOXY 5,6 DIHYDRO 2' DEOXYURIDINE; 5 CHLORO 5 (1 METHOXY 2,2 CHLOROETHYL) 6 METHOXY 5,6 DIHYDRO 2' DEOXYURIDINE; ANTIVIRUS AGENT; DEOXYURIDINE DERIVATIVE; GLUTATHIONE; PRODRUG; THYMIDINE PHOSPHORYLASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CHEMICAL BOND; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSFORMATION; ESCHERICHIA COLI; HERPES SIMPLEX VIRUS 1; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; CHROMATOGRAPHY, THIN LAYER; COLORING AGENTS; DEOXYURIDINE; DRUG DESIGN; ESCHERICHIA COLI; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; SIMPLEXVIRUS; TEMPERATURE; TETRAZOLIUM SALTS; THIAZOLES; THYMIDINE PHOSPHORYLASE; VERO CELLS;

ANIMALIA; DNA VIRUSES; ESCHERICHIA COLI; HERPES; HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 0038690152     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/1475636031000073115     Document Type: Article

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