Antitussive effects of leukotriene receptor antagonists

European Respiratory Review

Volumn 12, Issue 85, 2002, Pages 275-277

  Dicpinigaitis, P V ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Albert Einstein Hospital   (United States)

Author keywords

Asthma; Cough; Cough variant asthma; Leukotriene receptor antagonists; Leukotrienes; Zafirlukast

Indexed keywords

BRONCHODILATING AGENT; CORTICOSTEROID; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONTELUKAST; PLACEBO; PRANLUKAST; ZAFIRLUKAST; ZILEUTON;

ASTHMA; BRONCHITIS; BRONCHUS HYPERREACTIVITY; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; EOSINOPHILIA; HUMAN; INFLAMMATION; LUNG FUNCTION; META ANALYSIS; RANDOMIZED CONTROLLED TRIAL;

EID: 0038689462     PISSN: 09059180     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (21)

1. Schappert SM. Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 1995. Vital Health Stat 1997; 129: 1-38.
2. Irwin RS, Curley FJ, French CL. Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Am Rev Respir Dis 1990; 141: 640-647.
3. Brightling CE, Ward R, Goh KL, Wardlaw AJ, Pavord ID. Eosinophilic bronchitis is an important cause of chronic cough. Am J Respir Crit Care Med 1999; 160: 406-410.
4. Horwitz RJ, McGill KA, Busse WW. The role of leukotriene modifiers in the treatment of asthma. Am J Respir Crit Care Med 1998; 157: 1363-1371.
5. Corrao WM, Braman SS, Irwin RS. Chronic cough as the sole presenting manifestation of bronchial asthma. N Engl J Med 1979; 300: 633-637.
6. Irwin RS, French CT, Smymios NA, Curley FJ. Interpretation of positive results of a methacholine inhalation challenge and 1 week of inhaled bronchodilator use in diagnosing and treating cough-variant asthma. Arch Intern Med 1997; 157: 1981-1987.
7. Millar MM, McGrath KG, Patterson R. Malignant cough equivalent asthma: definition and case reports. Ann Allergy Asthma Immunol 1998; 80: 345-351.
8. Niimi A, Amitani R, Suzuki K, Tanaka E, Murayama T, Kuze F. Eosinophilic inflammation in cough variant asthma. Eur Respir J 1998; 11: 1064-1069.
9. Okada C, Horiba M, Matsumoto H, et al. A study of clinical features of cough variant asthma. Int Arch Allergy Immunol 2001; 125: Suppl. 1, 51-54.
10. Diamant Z, Sampson AP. Anti-inflammatory mechanisms of leukotriene modulators. Clin Exp Allergy 1999; 29: 1449-1453.
11. Busse WW. Does leukotriene modulation of eosinophil function explain the therapeutic effectiveness of receptor antagonists in some patients with asthma? Clin Exp Allergy 2001; 31: 806-807.
12. Minoguchi K, Kohno Y, Minoguchi H, et al. Reduction of eosinophilic inflammation in the airways of patients with asthma using montelukast. Chest 2002; 121: 732-738.
13. Yamauchi K, Tanifuji Y, Pan L-H, et al. Effects of pranlukast, a leukotriene receptor antagonist, on airway inflammation in mild asthmatics. J Asthma 2001; 38: 51-57.
14. Spector SL. Efficacy of anti-LT agents in the treatment of chronic asthma. Clin Rev Allergy Immunol 1999; 17: 235-246.
15. Nishi K, Watanabe K, Ooka T, Fujimura M, Matsuda T. Cough-variant asthma successfully treated with a peptide leukotriene receptor antagonist. Jpn J Thorac Dis 1997; 35: 117-123.
16. Dicpinigaitis PV, Dobkin JB, Reichel J. Antitussive effect of the leukotriene receptor antagonist zafirlukast in subjects with cough-variant asthma. J Asthma 2002; 39: 291-297.
17. Borish L. The role of leukotrienes in upper and lower airway inflammation and the implications for treatment. Ann Allergy Asthma Immunol 2002; 88: Suppl. I, 16-22.
18. Dicpinigaitis PV. Effect of zafirlukast, a leukotrienereceptor antagonist, on cough reflex sensitivity in healthy volunteers: a pilot study. Curr Ther Res 1999; 60: 15-19.
19. Dicpinigaitis PV, Dobkin JB. Effect of zafirlukast on cough reflex sensitivity in asthmatics. J Asthma 1999; 36: 265-270.
20. Niimi A, Matsumoto H, Minakuchi M, Kitaichi M, Amitani R. Airway remodeling in cough-variant asthma. Lancet 2000; 356: 564-565.
21. Henderson WR, Tang L-O, Chu S-J, et al. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med 2002; 165: 108-116.