Should infertile women with polycystic ovarian syndrome be treated with metformine?;Faut-il traiter par metformine les femmes infertiles présentant un syndrome des ovaires polykystiques?

Gynecologie Obstetrique et Fertilite

Volumn 31, Issue 3, 2003, Pages 265-274

  Massin, N ^a   Galey, J ^a   Basille, C ^a   Theron Gerard L ^a   Bry Gauillard, H ^a   Cedrin Durnerin I ^a   Hugues, J N ^a  

^a HÔPITAL JEAN VERDIER   (France)

Author keywords

Insulin resistance; Metformin; Ovarian stimulation; Polycystic ovary syndrome

Indexed keywords

CLOMIFENE CITRATE; FOLLITROPIN; METFORMIN;

DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; DRUG USE; FEMALE; FEMALE INFERTILITY; HORMONE RELEASE; HUMAN; HYPERANDROGENISM; HYPERINSULINEMIA; INSULIN RESISTANCE; OVARY CYCLE; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; PRACTICE GUIDELINE; REVIEW; SPONTANEOUS ABORTION; TREATMENT INDICATION;

EID: 0038683305     PISSN: 12979589     EISSN: 17696682     Source Type: Journal    
DOI: 10.1016/S1297-9589(03)00046-8     Document Type: Review

References (38)

1. Dunaif A, Segal KR, Futterweit W, Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 1989;38:1165-74.
2. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ. Quantitative Insulin Sensitivity Check Index: a simple accurate method for assessing insulin sensitivity in Humans. J Clin Endocrinol Metab 2000;85:2402-10.
3. Legro RS, Finegood D, Dunaif A. A fasting glucose to insulin ration is a useful measure of insulin sensitivity in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1998;83:2694-8.
4. Ovalle F, Azziz R. Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus. Fertil Steril 2002;77:1095-105.
5. Adashi EY, Hsueh JW, Yens SSC, Insulin enhancement of LH and FSH release by cultured pituitary cells. Endocrinol 1981;108:1441-9.
6. Nestler JE, Powers LP, Matt DW, Steingold KA, Plymate SR, Rittmaster RS, Clore JN, et al. A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome. J Clin Endocrinol Metab 1991;72:83-9.
7. Barbieri RL, Makris A, Randall RW, Daniels G, Kistner RW, Ryan KJ, Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J Clin Endocrinol Metab 1986;62:904-10.
8. Nestler JE, Jakubowicz DJ, de Vargas AF, Brik C, Quintero N, Medina F. Insulin stimulates Testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system. J Clin Endocrinol Metab 1998;83:2001-5.
9. Vendola KA, Zhou J, Adesanya OO, Well SJ, Bondy CA. Androgens stimulate early stages of follicular growth in the primate ovary. J Clin Invest 1998;101:2622-9.
10. Kolodziejczyk B, Duleba AJ, Spaczynski RL, Pawelczyk L, Metformin therapy decreases hyperandrogenism and hyperinsulinaemia in women with polycystic ovary syndrome. Fertil Steril 2000;73:1149-54.
11. De Leo V, La Marca A, Orvieto R, Morgante G. Affect of metformin on insulin-like growth factor (IGF)-1 and IGF-binding protein 1 in polycystic ovary syndrome. J Clin Endocrinol Metab 2000;85:1598-600.
12. Nestler JE, Jakubowicz DJ. Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian p450c17a activity and serum androgens. J Clin Endocrinol Metab 1997;82:4075-9.
13. la Marca A, Morgante G, Paglia T, Ciotta L, Cianci A, De Leo V. Effects of metformin on adrenal steroidogenesis in women with polycystic ovary syndrome. Fertil Steril 1999;72:985-9.
14. Crave JC, Fimbel S, Lejeune H, Cugnardey N, Déchaud H, Pugeat M. Effects of diet and Metformin administration on Sex-Hormone Biending Globulin, androgens and insulin in hirsute and obese women. J Clin Endocrinol Metab 1995;80:2057-62.
15. Ehrmann DA, Cavaghan MK, Imperial J, Sturis J, Rosenfield RL, Polonsky KS. Effects of Metformin on insulin secretion, insulin action, and ovarian steroidogenesis in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1997;82:524-30.
16. Acbay O, Gundogdu S. Can metformin reduce insulin resistance in polycystic ovary syndrome? Fertil Steril 1996;65:946-9.
17. Attia GR, Rainey WE, Carr BR. Metformin directly inhibits androgen production in human theca cells. Fertil Steril 2001;76:517-24.
18. Nestler JE, Jakubowicz DJ, Evans WS, Pasquali R. Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N Engl J Med 1998;338:1876-80.
19. Fleming R, Hopkinson ZE, Wallace AM, Greer IA, Sattar N. Ovarian function and metabolic factors in women with oligomenorrhea treated with Metformin in a randomized double blind placebo-controlled trial. JCEM 2002;87:569-74.
20. Ng EHY, Wat NMS, Ho PC. Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: a randomized, double-blinded placebo-controlled trial. Hum Reprod 2001;16:1625-31.
21. Morin-Papunen LC, Koivunen RM, Ruokonen A, Martikainen HK. Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome. Fertil Steril 1998;69:691-6.
22. Pirwany IR, Yates RWS, Cameron IT, Fleming R. Effects of the insulin sensitizing drug metformin on ovarian function, follicular growth and ovulation rate in obese women with oligomenorrhoea. Hum Reprod 1999;14:2963-8.
23. Moghetti P, Castello R, Negri C, Tosi F, Perrone F, Caputo M, Zanolin E, et al. Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrom: A randomized, double-mind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. JCEM 2000;85:139-46.
24. Velasquez EM, Acosta A, Mendoza SG, Menstrual cyclicity after metformin therapy in polycystic ovary syndrome. Obstet Gynecol 1997;90:392-5.
25. El-Biely MM, Habba M. The use of metformin to augment the induction of ovulation in obese infertile patients with polycystic ovary syndrome. Middle East Fertil Soc J 2001;6:43-9.
26. Vandermolen DT, Ratts VS, Evans WS, Stovall DW, Kauma SW, Nestler JE, Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone. Fertil Steril 2001;75:310-5.
27. Kocak M, Caliskan E, Simsir C, Haberal A. Metformin therapy improves ovulatory rates, cervical scores, and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome. Fertil Steril 2002;77:101-6.
28. Sturrock NDC, Lannon B, Fay TN, Metformin does not enhance ovulation induction in clomiphene resistant polycystic ovary syndrome in clinical practice. British. J Clin Pharmacol 2002;53:469-73.
29. Imani B, Eijkemans MJC, Te Velde ER, Habbema JDF, Fauser BCJM. Predictors of patients remaining anovulatory during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. J Clin Endocrinol Metab 1998;83:2361-5.
30. De Leo V, La Marca A, Ditto A, Morgante G, Cianci A. Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome. Fertil Steril 1999;72:282-5.
31. Yarali H, Yildiz BO, Demirol A, Zeyneloglu HB, Yigit N, Bukulmez O, Koray Z. Co-administration of metformin during rFSH treatment in patients with clomiphene citrate-resistant polycystic ovarian syndrome: a prospective randomized trial. Hum Reprod 2002;17:289-94.
32. Stadtmauer LA, Toma SK, Riehl RM, Talbert LM. Metformin treatment of patients with polycystic ovary syndrome undergoing in vitro fertilization improves outcomes and is associated with modulation of the insulin-like growth factors. Fertil Steril 2001;75:505-9.
33. Stadtmauer LA, Toma SK, Riehl RM, Talbert LM. Impact of metformin therapy on ovarian stimulation and outcome in "coasted" patients with polycystic ovary syndrome undergoing in-vitro fertilization. Reproductive BioMedicine Online 2002;5:112-6.
34. Glueck CJ, Philips H, Cameron D, Sieve-Smith L, Wang P. Continuing Metformin throughout pregnacy in women with polycystic ovary syndrome apperars to safety reduce first-trimester spontaneous abortion: a pilot study. Fertil Steril 2001;75:46-52.
35. Jakubowicz DJ, Iurno MJ, Jakubowicz S, Roberts KA, Nestler JE. Effects of metformin on early pregnancy loss in the polycysticovary syndrome. J Clin Endocrinol Metab 2002;87:524-9.
36. Heard MJ, Pierce A, Carson SA, Buster JE. Pregnancies following use of metformin for ovulation induction in patients with polycystic ovary syndrome. Fertil Steril 2002;77:669-73.
37. Jakubowicz DJ, Seppälä M, Jakubowicz S, Rodriguez-Armas O, Rivas-Santiago A, Koistinen H, Koistinen R, et al. Insulin reduction with Metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome. J Clin Endocrinol Metab 2001;86:1126-33.
38. Hugues JN, Bry H, Attali JR, Lormeau B. Assistance médicale à la procréation et diabète. Paris: McCann Santé; 2002.