Micronodular T-cell/histiocyte-rich large B-cell lymphoma of the spleen: Histology, immunophenotype, and differential diagnosis

American Journal of Surgical Pathology

Volumn 27, Issue 7, 2003, Pages 903-911

  Dogan, Ahmet ^a   Burke, Jerome S ^b   Goteri, Gaia ^c   Stitson, Richard N M ^d   Wotherspoon, Andrew C ^e   Isaacson, Peter G ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ALTA BATES SUMMIT MEDICAL CENTER   (United States)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^d LEICESTER ROYAL INFIRMARY   (United Kingdom)

^e ROYAL MARSDEN HOSPITAL   (United Kingdom)

Author keywords

Diffuse large B cell lymphoma; Immunohistochemistry; Lymphoma; Spleen; T cell histiocyte rich

Indexed keywords

CD20 ANTIGEN; CD3 ANTIGEN; CD30 ANTIGEN; CD79A ANTIGEN; CHLORDANE; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; EPITHELIAL MEMBRANE ANTIGEN; EPSTEIN BARR VIRUS ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN LIGHT CHAIN; OCTAMER TRANSCRIPTION FACTOR 2; PARAFFIN; PROTEIN; PROTEIN BCL 2; PROTEIN BCL 6; SYNDECAN 1; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; B CELL LYMPHOMA; CANCER DIAGNOSIS; CANCER MORTALITY; CLINICAL ARTICLE; DENDRITIC CELL; DIFFERENTIAL DIAGNOSIS; FEMALE; FOLLICULAR LYMPHOMA; FOLLOW UP; GRANULOMATOUS INFLAMMATION; HISTIOCYTE; HISTOPATHOLOGY; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LARGE CELL LYMPHOMA; MALE; PROGNOSIS; REVIEW; SPLEEN; T CELL LYMPHOMA; T LYMPHOCYTE;

ADULT; AGED; AGED, 80 AND OVER; DNA, NEOPLASM; FEMALE; HISTIOCYTES; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION; LYMPHOMA, B-CELL; LYMPHOMA, LARGE-CELL, DIFFUSE; MALE; MIDDLE AGED; RIBOSOMAL PROTEINS; RNA-BINDING PROTEINS; SPLENIC NEOPLASMS; T-LYMPHOCYTES; TUMOR MARKERS, BIOLOGICAL;

EID: 0038678030     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200307000-00005     Document Type: Article

References (23)

1. Achten R, Verhoef G, Vanuytsel L, et al. Histiocyte-rich, T-cell-rich B-cell lymphoma: a distinct diffuse large B-cell lymphoma subtype showing characteristic morphologic and immunophenotypic features. Histopathology 2002;40:31-45.
2. Achten R, Verhoef G, Vanuytsel L, et al. T-cell/histiocyte-rich large B-cell lymphoma: a distinct clinicopathologic entity. J Clin Oncol 2002;20:1269-77.
3. Arber DA, Rappaport H, Weiss LM. Non-Hodgkin's lymphoproliferative disorders involving the spleen. Mod Pathol 1997;10:18-32.
4. Attygalle A, Al Jehani R, Diss TC, et al. Neoplastic T cells in angioimmunoblastic T-cell lymphoma express CD 10. Blood 2002;99:627-33.
5. Betman HF, Vardiman JW, Lau J. T-cell-rich B-cell lymphoma of the spleen. Am J Surg Pathol 1994;18:323-4.
6. Brousset P, Chittal SM, Schlaifer D, et al. T-cell rich B-cell lymphoma in the lung. Histopathology 1995;26:371-3.
7. Burke JS. Splenic lymphoid hyperplasias versus lymphomas/leukemias: a diagnostic guide. Am J Clin Pathol 1993;99:486-93.
8. Burke JS. The spleen. In: Stemberg SS, ed. Diagnostic Surgical Pathology, 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 1999:779-802.
9. Castroagudin JF, Gonzalez-Quintela A, Fraga M, et al. Presentation of T-cell-rich B-cell lymphoma mimicking acute hepatitis. Hepatogastroenterology 1999;46:1710-3.
10. Chan WC. T-cell-rich B-cell lymphoma: what is new? What is cool? Am J Clin Pathol 1997;108:489-91.
11. Chang KL, Kamel OW, Arber DA, et al. Pathologic features of nodular lymphocyte predominance Hodgkin's disease in extranodal sites. Am J Surg Pathol 1995;19:1313-24.
12. Delabie J, Vandenberghe E, Kennes C, et al. Histiocyte-rich B-cell lymphoma: a distinct clinicopathologic entity possibly related to lymphocyte predominant Hodgkin's disease, paragranuloma subtype. Am J Surg Pathol 1992;16:37-48.
13. Dogan A, Bagdi E, Munson P, et al. CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas. Am J Surg Pathol 2000;24:846-52.
14. Isaacson PG, Norton A. Malignant lymphoma of the spleen. In: Extranodal Lymphomas. Edinburgh: Churchill Livingstone, 1994:241-72.
15. Kraemer BB, Osborne BM, Butler JJ. Primary splenic presentation of malignant lymphoma and related disorders: a study of 49 cases. Cancer 1984;54:1606-19.
16. Li S, Griffin CA, Mann RB, et al. Primary cutaneous T-cell-rich B-cell lymphoma: clinically distinct from its nodal counterpart? Mod Pathol 2001;14:10-3.
17. McBride JA, Rodriguez J, Luthra R, et al. T-cell-rich B large-cell lymphoma simulating lymphocyte-rich Hodgkin's disease. Am J Surg Pathol 1996;20:193-201.
18. Mollejo M, Algara P, Mateo M, et al. Splenic primary large B cell lymphoma: a clinicopathologic study. Mod Pathol 2002;15:1064.
19. Ramsay AD, Smith WJ, Isaacson PG. T-cell-rich B-cell lymphoma. Am J Surg Pathol 1988;12:433-43.
20. Rudiger T, Ott G, Ott MM, et al. Differential diagnosis between classic Hodgkin's lymphoma, T-cell-rich B-cell lymphoma, and paragranuloma by paraffin immunohistochemistry. Am J Surg Pathol 1998;22:1184-91.
21. Skinnider BF, Connors JM, Gascoyne RD. Bone marrow involvement in T-cell-rich B-cell lymphoma. Am J Clin Pathol 1997;108:570-8.
22. Stein H, Marafioti T, Foss HD, et al. Downregulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription. Blood 2001;97:496-501.
23. Stroup RM, Burke JS, Sheibani K, et al. Splenic involvement by aggressive malignant lymphomas of B-cell and T-cell types: a morphologic and immunophenotypic study. Cancer 1992;69:413-20.