Protein kinase A and protein kinase C signaling pathway interaction in phenylethanolamine N-methyltransferase gene regulation

Journal of Neurochemistry

Volumn 85, Issue 3, 2003, Pages 816-829

  Tai, T C ^a   Wong, Dona L ^a  

^a MCLEAN HOSPITAL   (United States)

Author keywords

Egr 1; Gene transcription; PC12 cells; Phenylethanolamine N methyltransferase; Protein kinase A; Protein kniase C

Indexed keywords

ADENYLATE CYCLASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENZYME INHIBITOR; FORSKOLIN; LUCIFERASE; N (2 PHENYLCYCLOPENTYL)AZACYCLOTRIDECAN 2 IMINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHENYLETHANOLAMINE N METHYLTRANSFERASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; TRANSCRIPTION FACTOR EGR 1; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; CELL STRAIN; CONTROLLED STUDY; DNA PROTEIN COMPLEX; DNA RESPONSIVE ELEMENT; DNA SEQUENCE; ENZYME ACTIVATION; GENE ACTIVATION; GENE CONTROL; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; MUTATION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CONTENT; REPORTER GENE; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0038673428     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01728.x     Document Type: Article

References (62)

1. Boussif O., Lezoualc F., Zanta M. A., Mergny M. D., Scherman D., Demeneix B. and Behr J.-P. (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl Acad. Sci. USA 92, 7297-7301.
2. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
3. Cao X., Mahendran R., Guy G. and Tan Y. H. (1992) Protein phosphatase inhibitors induce the sustained expression of the Egr-1 gene and the hyperphosphorylation of its gene product. J. Biol. Chem. 267, 12991-12997.
4. Choi H. J., Park S. Y. and Hwang O. (1999) Differential involvement of PKA and PKC in regulation of catecholamine enzyme genes by PACAP. Peptides 20, 817-822.
5. Christy B. and Nathans D. (1989) DNA binding site of the growth factor-inducible protein Zif268. Proc. Natl Acad. Sci. USA 86, 8737-8741.
6. Chumakov A. M., Chen D. L., Chumakova E. A. and Koeffier H. P. (1993) Localization of the c-ets-2 transactivation domain. J. Virol. 67, 2421-2425.
7. D'Angelo D. D., Oliver B. G., Davis M. G., McCluskey T. S. and Dorn I. I. G. W. (1996) Novel role for Sp1 in phorbol ester enhancement of human platelet thromboxane receptor gene expression. J Biol. Chem. 271, 19696-19704.
8. Daniel P. B., Walker W. H. and Habener J. F. (1998) Cyclic AMP signaling and gene regulation. Ann. Rev. Nutr. 18, 353-383.
9. Duman R. S., Strada S. J. and Enna S. J. (1989) Glucocorticoid administration increases receptor-mediated and forskolin-stimulated cyclic AMP accumulation in rat brain cerebral cortical slices. Brain Res. 477, 166-171.
10. Ebert S. N. and Wong D. L. (1995) Differential activation of the rat phenylethanolamine N-methyltransferase gene by Sp1 and Egr-1. J. Biol. Chem. 270, 17299-17305.
11. Ebert S. N., Balt S. L., Hunter J. P. B., Gashler A., Sukhatme V. and Wong D. L. (1994) Egr-1 activation of rat adrenal phenylethanolamine N-methyltransferase gene. J. Biol. Chem. 269, 20885-20898.
12. Ebert S. N., Ficklin M. B., Her S., Siddall B. J., Bell R. A., Morita K., Ganguly K. and Wong D. L. (1998) Glucocorticoid-dependent action of neural crest factor AP-2: stimulation of phenylethanolamine N-methyltransferase gene expression. J. Neurochem. 70, 2286-2295.
13. Evinger M. J., Ernsberger P, Regunathan S., Joh T. H. and Reis D. J. (1994) A single transmitter regulates gene expression through two separate mechanisms: cholinergic regulation of phenylethanolamine N-methyltransferase mRNA via nicotinic and muscarinic pathways. J Neurosci. 14, 2106-2116.
14. Fischer-Colbrie R., Eskay R. L., Eiden L. E. and Mass D. (1992) Transsynaptic regulation of galanin, neurotensin, and substance P in the adrenal medulla: combinatorial control by second-messenger signaling pathways. J. Neurochem. 59, 780-783.
15. 2+ influx requires cAMP-dependent protein kinase in PC12 cells. J. Biol. Chem. 266, 17454-17458.
16. Graness A., Adomeit A., Ludwig B., Muller W. D., Kaufman R. and Liebmann C. (1997) Novel bradykinin signalling events in PC-12 cells: stimulation of the cAMP pathway leads to cAMP-mediated translocation of protein kinase Cε. Biochem. J. 327, 147-154.
17. Gusovsky F. and Gutkind J. S. (1991) Selective effects of activation of protein kinase C isozymes on cyclic AMP accumulation. Mol. Pharmacol. 39, 124-129.
18. Her S., Bell R. A., Bloom A. K., Siddall B. J. and Wong D. L. (1999) Phenylethanolamine N-methyltransferase gene expression: Sp1 and MAZ potential for tissue specific expression. J. Biol. Chem, 274, 8698-8707.
19. Huang R.-P. and Adamson E. D. (1994) The phosphorylated forms of the transcription factor, Egr-1 bind to DNA more efficiently than nonphosphorylated. Biochem. Biophys. Res. Commun. 200, 1271-1276.
20. Hwang O., Kim M. L., and Lee J. D. (1994) Differential induction of gene expression of catecholamine biosynthetic enzymes and preferential increase in norepinephrine by forskolin. Biochem. Pharmacol. 48, 1927-1934.
21. Hwang O., Park S. Y. and Kim K. S. (1997) Protein kinase A coordinately regulates both basal expression and cyclic AMP-mediated induction of three catecholamine-synthesizing enzyme genes. J. Neurochem. 68, 2241-2247.
22. Isobe K., Yukimasa N., Nakai T. and Takuwa Y. (1996) Pituitary adenylate cyclase-activating polypeptide induces gene expression of the catecholamine synthesizing enzymes, tyrosine hydroxylase and dopamine beta hydroxylase, through 3′,5′-cyclic adenosine monophosphate- and protein kinase C-dependent mechanisms in cultured porcine adrenal medullary chromaffin cells. Neuropeptides 30, 167-175.
23. Kim K.-S., Ishiguro H., Tinti C., Wagner J. and Joh T. H. (1994a) The cAMP-dependent protein kinase regulates transcription of the dopamine β-hydroxylase gene. J. Neurosci. 14, 7200-7207.
24. Kim K.-S., Tinti C., Song B., Cubells J. F. and Joh T. H. (1994b) Cyclic AMP-dependent protein kinase regulates basal and cyclic AMP-stimulated but not phorbol ester-stimulated transcription of the tyrosine hydroxylase gene. J. Neurochem. 63, 834-842.
25. Kim J. S., Nam J. S., Chae H. D. and Kim K. T. (1997) A protein kinase C-activating phorbol ester enhances transcription of the human DBH gene through a cyclic AMP response element in SK-NBE(2)C cells. Mol. Brain Res. 51, 154-160.
26. Lee Y. S., Raia G., Tonshoff C. and Evinger M. J. (1999) Neural regulation of phenylethanolamine N-methyltransferase (PNMT) gene expression in bovine chromaffin cells differs from other catecholamine enzyme genes. J. Mol. Neurosci. 12, 53-68.
27. Lewis E. J., Tank A. W., Weiner N. and Chikaraishi D. M. (1983) Regulation of tyrosine hydroxylase mRNA by glucocorticoids and cyclic AMP in a rat pheochromocytoma cell line. J. Biol. Chem. 258, 14632-14637.
28. Lewis E. J., Harrington C. A. and Chikaraishi D. M. (1987) Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoids and cAMP. Proc. Natl Acad. Sci. USA 84, 3553-3554.
29. Malhotra R. K., Wakade T. D. and Wakade A. R. (1989) Cross-communication between acetylcholine and VIP in controlling catecholamine secretion by affecting cAMP, inositol trisphosphate, protein kinase C and calcium in rat adrenal medulla. J. Neurosci. 9, 4150-4157.
30. Morita K. and Wong D. L. (1996) Role of Egr-I in cholinergic stimulation of phenylethanolarnine N-methyltransferase promoter. J. Neurochem. 67, 1344-1351.
31. Morita K., Ebert S. N. and Wong D. L. (1995) Role of transcription factor Egr-I in phorbol ester-induced phenylethanolamine N-methyltransferase gene expression. J. Biol. Chem. 270, 11161-11167.
32. Morita K., Bell R. A., Siddall B. J. and Wong D. L. (1996) Neural stimulation of Egr-I messenger RNA expression in rat adrenal gland: possible relation to phenylethanolamine N-methyltransferase gene regulation. J. Pharmacol. Exp. Ther. 279, 379-385.
33. Park K. and Kim K. H. (1993) The site of cAMP action in the insulin induction of gene expression of acetyl-CoA carboxylase is AP-2. J. Biol. Chem. 268, 17811-17819.
34. Piech-Dumas K. M. and Tank A. W. (1999) CREB mediates the cAMP-responsiveness of the tyrosine hydroxylase gene: use of antisense RNA strategy to produce CREB-deficient PC12 cell lines. Mol. Brain Res. 70, 219-230.
35. Piech-Dumas K. M., Best J. A., Chen Y., Nagamoto-Combs K., Osterhout C. A. and Tank A. W. (2001) The cAMP response element and CREB partially mediate the response of the tyrosine hydroxylase gene to phorbol ester. J. Neurochem. 76, 1376-1385.
36. Rana B., Xie Y., Mischoulon D., Bucher N. L. and Farmer S. R. (1995) The DNA binding activity of C/EBP transcription factor is regulated in the GI phase of the heptocyte cell cycle. J. Biol. Chem. 270, 18123-18132.
37. Rodan S. B. and Rodan G. A. (1986) Dexamethasone effects on β adrenergic receptors and adenylate cyclase regulatory proteins Gs and Gi in ROS 17/2.8 cells. Endocrinology 118, 2510-2518.
38. Ross M. E., Evinger M. J., Hyman S. E., Carroll J. M., Mucke L., Comb M., Reis D, J., Joh T. H. and Goodman H. M. (1990) Identification of a functional glucocorticoid response element in the phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary culture. J. Neurosci. 10, 520-530.
39. Schalling M., Dagerlund A., Brene S., Hallman H., Djurfeldt M., Persson H., Terenius L., Goldstein M., Schlesinger D. and Hokfelt T. (1988) Coexistence and gene expression of phenylethanolamine N-methyltransferase, tyrosine hydroxylase, and neuropeptide tyrosine in the rat and bovine adrenal gland: effects of reserpine. Proc. Natl Acad. Sci. USA 85, 8306-8310.
40. Schreiber J., Enderich J. and Wegner M. (1998) Structural requirements for DNA binding of GCM proteins. Nucleic Acids Res. 26, 2337-2343.
41. Shaskus J., Greco D., Asnani L. P. and Lewis E. J. (1992) A bifunctional genetic regulatory element of the rat dopamine β-hydroxylase gene influences cell type specificity and second messenger-mediated transcription. J. Biol. Chem. 267, 18821-18830.
42. Stachowiak M. K., Hong J. S. and Viveros O. H. (1990) Coordinate and differential regulation of phenylethanolamine N-methyltransferase, tyrosine hydroxylase and proenkephalin mRNAs by neural and hormonal mechanisms in cultured bovine adrenal medullary cells. Brain Res. 510, 277-288.
43. Stachowiak M. K., Goc A., Hong J.-S., Poisner A., Jiang H.-K, and Stachowiak E. K. (1994) Regulation of tyrosine hydroxylase gene expression in depolarized non-transformed bovine adrenal medullary cells: second messenger systems and promoter mechanisms. Mol. Brain Res. 22, 309-319.
44. Swanson D. J., Zellmer E. and Lewis E. J.~ (1998) API proteins mediates the cAMP response of the dopamine 13-hydroxylase gene. J. Biol. Chem. 273, 24065-24074.
45. Tai T. C., Morita K. and Wong D. L. (2001) Role of Egr-1 in cAMP-dependent protein kinase regulation of the phenylethanolamine N-methyltransferase gene. J. Neurochem. 76, 1851-1859.
46. Tonshoff C., Hemmick L. and Evinger M. J. (1997) Pituitary adenylate cyclase activating polypeptide (PACAP) regulates expression of catecholamine biosynthetic enzyme genes in bovine adrenal chromaffin cells. J. Mol. Neurosci. 9, 127-140.
47. Tsai-Morris C.-H., Cao X. and Sukhatme V. P. (1988) 5′ flanking sequence and genomic structure of Egr-1, a murine mitogen inducible zinc finger encoding gene. Nucleic Acids Res. 16, 8835-8846.
48. Tuerk E. E., Schreiber J. and Wegner M. (2000) Protein stability and domain topology determine the transcriptional activity of the mammalian glial cells missing homolog, GCMb. J. Biol. Chem. 275, 4774-4782.
49. Uhler M. D., Chrivia J. C. and McKnight G. S. (1986) Evidence for a second isoform of the catalytic subunit of cAMP-dependent protein kinase. J. Biol. Chem. 261, 15360-15363.
50. Vaudry D., Gonzalez B. J., Basille M., Yon L., Fournier A. and Vaudry H. (2000) Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions. Pharmacol. Rev 52, 269-324.
51. Venepally P. and Waterman M. R. (1995) Two Sp1-binding sites mediate cAMP-induced transcription of the bovine CYP11A gene through the protein kinase A signaling pathway. J Biol. Chem. 43, 25402-25410.
52. Vossler M. R., Yao H., York R. D., Pan M.-G., Rim C. S. and Stork P. J. S. (1997) cAMP activates MAP kinase and Elk-1 through a B-Raf and Rap1-dependent pathway. Cell 89, 73-82.
53. Wakade A. R. (1988) Non-cholinergic transmitter(s) maintains secretion of catecholamines from rat adrenal medulla for several hours of continuous stimulation of splanchnic neurons. J Neurochem. 50, 1302-1308.
54. Wan D. D.-C., Marley P. D. and Livett B. G. (1991) Coordinate and differential regulation of proenkephalin A and PNMT mRNA expression in cultured bovine adrenal chromaffin cells: responses to secretory stimuli. Mol. Brain. Res. 9, 103-111.
55. Watanabe T., Masuo Y., Matsumoto H., Suzuki N., Ohtaki T., Masuda Y., Kitada C., Tsuda M. and Fujino M. (1992) Pituitary adenylate cyclase-activating polypeptide provokes cultured rat chromaffin cells to secrete adrenaline. Biochem. Biophys. Res. Commun. 182, 403-411.
56. Wessel T. C. and Joh T. H. (1992) Parallel upregulation of catecholamine-synthesizing enzymes in rat brain and adrenal gland: effects of reserpine and correlation with immediate early gene expression. Mol. Brain Res. 15, 349-360.
57. Wiemann S., Steuer B., Alonso A., Kinzel V. and Pyerin W. (1996) Promoter of the gene encoding the bovine catalytic subunit of cAMP-dependent protein kinase isoform C beta 2. Biochim. Biophys. Acta 1309, 211-220.
58. Wong D. L., Bildstein C. L., Siddall B., Lesage A. and Yoo Y. S. (1993) Neural regulation of phenylethanolamine N-methyltransferase in vivo: transcriptional and translational changes. Mol. Brain Res. 18, 107-114.
59. Wong D. L., Siddall B. J., Ebert S. N., Bell R. A. and Her S. (1998) Phenylethanolamine N-methyltransferase gene expression: synergistic activation by Egr-1, AP-2 and the glucocorticoid receptor. Mol. Brain Res. 61, 154-161.
60. Wong D. L., Anderson L. J. and Tai T. C. (2002) Cholinergic and peptidergic regulation of phenylethanolamine of N-methyltransferase, in Chromaffin Cell: Transmitter Biosynthesis, Storage, Release, Actions and Informatics (O'Connor D. T. and Eiden L. E., eds). Ann. NY Acad. Sci. 971, 19-26.
61. Wooten M. W., Seibenhener M. L., Matthews L. H., Zhou G. and Coleman E. S. (1996) Modulation of η-protein kinase C by cyclic AMP in PC12 cells occur through phosphorylation by protein kinase A. J. Neurochem. 67, 1023-1031.
62. Yoshimasa T., Sibley D. R., Bouvier M., Lefkowitz R. J. and Caron M. G. (1987) Cross-talk between cellular signaling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation. Nature 327, 67-70.